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Global data collected between 2014 and 2024 provide insights into the distribution and potential transport mechanisms of subsurface microplastics throughout the oceanic water column.
A life cycle assessment study is used to examine the impacts of advanced cooling technologies on cloud infrastructure, from virtual machines to server architecture, data centre buildings and the grid.
A study aimed at revealing the role of small-scale fisheries in sustainable development shows they provide at least 40% of the global fishing catch and affect the livelihoods of 1 in 12 people in the world, among other important contributions.
We discuss the potential consequences and ethical concerns of polygenic genome editing of human embryos to alter specific variants associated with polygenic diseases, highlighting the possibility of reducing disease susceptibility while exacerbating health inequalities.
We find that conservatives tend to share more low-quality news through social media than liberals, and so even if technology companies enact politically neutral anti-misinformation policies, political asymmetries in enforcement should be expected.
A study demonstrates the interpretation of a neuronal wiring diagram of the optic lobe of Drosophila, yielding theoretical predictions about visual functions of this structure.
Human genetic evidence increases the success rate of drugs from clinical development to approval but we are still far from reaching peak genetic insights to aid the discovery of targets for more effective drugs.
Efficiency roll-off in a wide range of TADF OLEDs is analysed and a figure of merit proposed for materials design to improve efficiency at high brightness, potentially expanding the range of applications of TADF materials.
A study examining how cities can foster well-being and positive mental health in young residents synthesizes opinions from researchers, practitioners, advocates and young people, highlighting factors that policymakers and urban planners should consider.
Analyses of drivers of water stress are used to predict likely trajectories of the Amazon forest system and suggests potential actions that could prevent system collapse.
Msemburi et al. describe how the World Health Organization has estimated the excess mortality associated with the COVID-19 pandemic, by month and for 2020 and 2021, and analyse their estimates across the WHO member states, with 14.83 million global excess deaths estimated.
Matched Annotation from NCBI and EMBL-EBI (MANE) delivers joint transcript sets from Ensembl/GENCODE and RefSeq for standardizing variant reporting in clinical genomics and research.
A whole-genome alignment of 240 phylogenetically diverse species of eutherian mammal—including 131 previously uncharacterized species—from the Zoonomia Project provides data that support biological discovery, medical research and conservation.
Analysis of predicted loss-of-function variants from 125,748 human exomes and 15,708 whole genomes in the Genome Aggregation Database (gnomAD) provides a roadmap for human ‘knockout’ studies and a guide for future research into disease biology and drug-target selection.
Climate has affected organized armed conflict within countries, and intensifying climate change is estimated to increase future risks of conflict, although other drivers are substantially more influential and the mechanisms of climate–conflict linkages remain uncertain.
The characterization of missense histone mutations that occur across several cancer types provides insight into the potential role of these mutations in altering chromatin structure and potentially contributing to tumour development.
Analysis of 2002–2016 GRACE satellite observations of terrestrial water storage reveals substantial changes in freshwater resources globally, which are driven by natural and anthropogenic climate variability and human activities.
