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Concise routes to 25 naturally occurring picrotoxanes were devised using a virtual library of intermediate analogues triaged by reactivity; this approach can overcome challenges in the use of computers for synthesis design.
Understanding the chemistry of perovskite precursor solutions enables improved film optoelectronic properties, allowing the fabrication of multijunction solar cells achieving power conversion efficiencies beyond the radiative limit of single-junction cells.
Signatures of superconductivity in La3Ni2O7 thin films are demonstrated, facilitated by the application of epitaxial compressive strain, suggesting that the observed low zero resistance Tc of around 2 K can be attributed to several factors.
Edge-exposed exfoliation using sticky tape is shown to be a simple and reliable method for scaling up the production of ultrathin, ultraflat and ultraflexible polycrystalline diamond membranes for diverse electrical, optical, mechanical, thermal, acoustic and quantum applications.
Lithocholic acid is one of the metabolites upregulated during calorie restriction, and treatment of mice, worms and flies with this bile acid alone can reproduce the health benefits of calorie restriction.
The molecular mechanism underlying how lithocholic acid recapitulates the lifespan and healthspan benefits of calorie restriction is revealed to involve TULP3, sirtuins, v-ATPase and AMPK.
Using a deep neural network and statistical analyses of atomic force microscopy images of individual RNA molecules enables the mapping of RNA conformational space in solution.
Laser excitation of the 229Th isomer, potentially relevant for nuclear clocks, is reported in thorium fluoride thin films, which are less radioactive and amenable to integration compared with existing thorium-doped crystals.
A eutectic phase change material composed of boric and succinic acids demonstrates a transition at around 150 °C, with a record high reversible thermal energy uptake and thermal stability over 1,000 heating–cooling cycles.
This study demonstrates that diatoms with phytochrome photoreceptors can detect and functionally respond to the entire visible light spectrum through these sensors, enabling them to sense depth and regulate photosynthesis accordingly in marine environments.
A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T cells and rejuvenation associated with neural stem cells.
Intense terahertz pulses are used to induce metastable magnetization with a remarkably long lifetime of more than 2.5 milliseconds in a van der Waals antiferromagnet, FePS3.
A new computational method for design of pseudosymmetric self-assembling protein nanomaterials has resulted in purification of cage-like protein assemblies containing 960 subunits with a diameter of 96 nm.
Through analysis of developing chick embryos and in vitro differentiation of embryonic stem cells, a study develops a method to generate a model of the human trunk with a notochord.
Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene amplifications in human cancers.
Seasons with more frequent atmospheric rivers (ARs) also have warmer than average temperatures in many mid-latitude regions, and AR events are associated with temperature anomalies of 5–10 °C above the climatological mean.
HORNET, a method that uses unsupervised machine learning and deep neural networks to analyse atomic force microscopy data enables structural determination of RNA molecules in multiple conformations.
