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This Resource presents a method to define connectivity types of neurons based on a spatially registered large database containing more than 20,000 neuronal reconstructions. A brain connectivity map is also generated using such connectivity features.
This Resource describes data, code and tools developed for the Human Reference Atlas and the Human BioMolecular Atlas Program for building and navigating a multiscale human atlas.
An optical pooled cell profiling platform (PERISCOPE) based on Cell Painting and optical sequencing of molecular barcodes was used to develop the first unbiased genome-wide morphology-based perturbation atlas in human cells.
scAtlasVAE is a deep learning-based model for cross-atlas integration. Here it enables the development of a large-scale human CD8+ T cell atlas with integrated T cell receptor data.
This manuscript reports a high-throughput platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs by using a library of membrane-active polymers while maintaining their local membrane context.
This resource integrates different human embryo datasets to create a transcriptional reference map of human embryonic development from zygote to gastrula.
The Genomics 2 Proteins portal is an open-source tool for proteome-wide linking of human genetic variants to protein sequences and structures. The portal serves as a discovery tool to hypothesize the structure–function relationship between natural or synthetic variations and their molecular phenotypes.
This resource presents a high-resolution diffusion MRI dataset of a chimpanzee brain, which should be useful for evolutionary studies of primate brain evolution.
The CPJUMP1 Resource comprises Cell Painting images and profiles of 75 million cells treated with hundreds of chemical and genetic perturbations. The dataset enables exploration of their relationships and lays the foundation for the development of advanced methods to match perturbations.
An updated version of the Waxholm Space atlas of the rat brain includes more detailed annotations of several brain regions, including the cortex, striatopallidal region, midbrain and thalamus, expanding the previous version with 112 new and 57 revised structures.
EmbryoNet is an automated approach to the phenotyping of developing embryos that surpasses experts in terms of speed, accuracy and sensitivity. A large annotated image dataset of zebrafish, medaka and stickleback development rounds out this resource.
This resource describes a collection of neurons from a variety of light microscopy-based datasets, which can serve as a gold standard for testing automated tracing algorithms, as shown by comparison of the performance of 35 algorithms.
The outbreak.info genomic reports provides comprehensive and detailed information about SARS-CoV-2 lineages and mutations worldwide, which facilitates near real-time genomic surveillance.
Spatial Omics DataBase (SODB) is a web-based platform for sharing and analyzing >25 types of spatial omics data. SODB promotes data reuse, offers novel visualization tools and can streamline development of omics analysis tools.
The AlphaFill algorithm transplants missing small molecules and ions from experimentally determined structures to predicted protein models in the AlphaFold protein structure database. All AlphaFill entries are available for visual inspection and download through the AlphaFill website.
This Resource presents and analyzes four datasets containing both gene expression and morphological profile data for cells subjected to hundreds to thousands of chemical or genetic perturbations and highlights their complementary nature.
