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Hexa-acylated lipopolysaccharides from the gut microbiota are associated with efficacy in patients with cancer receiving anti-PD-1 and stimulate host immune activation for enhanced anti-tumour immunity in mouse models.
Assessing more than 12,000 metagenomic samples from across the world using computational approaches, the authors determined interactions between species that co-colonize or co-exclude Enterobacteriaceae in terms of functional pathways and metabolites in healthy human gut microbiomes.
A metagenomic CRISPR screening approach identifies an expansive diversity of viruses and mobile genetic elements infecting the enigmatic ultrasmall DPANN archaea.
Computational cloud-based screen of vertebrate genomes identifies endogenous viral elements of members of the kingdoms Shotokuvirae and Orthornavirae and informs about evolutionary history of non-retroviral elements.
Surveying next generation sequencing capabilities in 13 Asian countries identifies challenges to be met for improved implementation, pathogen surveillance and integration into public health decision-making.
A set of computational tools to de novo recognize plasmids in complex environments, like the human gut microbiome, and to organize them into evolutionarily cohesive units.
Automated and scalable designation of virus lineages based on a heuristic approach can help to determine and curate virus lineages from large genomic datasets and inform nomenclature.
Ocean viral proteome annotations are expanded by a machine learning approach that is not reliant on sequence homology and can annotate sequences not homologous to those seen in training.
Phylogenetics and convergence-based genome-wide association studies were used to analyse genomic variants across approximately 2,000 isolates from six Candida species to reveal how Candida fungal pathogens adapt to drugs and clinical environments.
A postnatal multiple micronutrient deficiency mouse model reveals shifts in bacterial, fungal and viral components of the gut microbiome with implications for microbiome-encoded intrinsic antibiotic resistance mechanisms.
Culture-independent CRISPR spacer screens enable the discovery of hundreds of viruses and mobile genetic elements infecting all known methanogenic lineages.
Systematic review and analysis of pre-pandemic coronavirus surveillance in bats identifies requirements for improvements to surveillance in the future.
