Genome Watch

This Genome Watch article discusses the dominance of uncultivated microorganisms in natural ecosystems and how the consequent genome-driven insights could guide the rational design of synthetic microbial communities.

This Genome Watch highlights the advantages and limitations of k-mer approaches versus standard alignment-based methods for analysing metagenomic data, assisting microbial species identification, microbial abundance estimation and their application in pathogen genomic epidemiology.

This Genome Watch article highlights recent findings of cellular-like genes in giant viruses and how these viruses acquire and repurpose host cellular machinery.

This Genome Watch discusses advancements in our understanding of interpersonal transmission dynamics of the human gut microbiota and their implications for host health and therapeutic outcomes.

This Genome Watch highlights how genomic lineage resolution is revolutionizing precision diagnostics by providing insights into pathogen evolution, transmission dynamics and the emergence of antimicrobial resistance.

This Genome Watch article highlights how genomics and different experimental approaches reveal how intracellular bacteria control key processes of their hosts.

This Genome Watch discusses strategies to detect small open reading frames and study microproteins encoded in microbiomes to understand their diversity and functions across microorganisms.

This Genome Watch article highlights recent findings that expand the known diversity of methanogenic archaea and the metagenomic evidence that led to their identification and cultivation.

This Genome Watch discusses the use of metagenomic sequencing to investigate resistome dynamics in river ecosystems and their associations with the mobilome and microbiome, underscoring the role of rivers as reservoirs of antimicrobial resistance genes.

This Genome Watch explores recent transcriptomic and metatranscriptomic analyses that revealed the key role of secondary endosymbionts in host immunity and disease transmission within their insect or plant hosts.

This Genome Watch highlights how the revived interest in phages that target plasmid-carrying bacteria is expanding our knowledge of viral diversity, ecology and evolution, which is fundamental for developing safe biotherapeutics.

This Genome Watch highlights recent metagenomic surveys that have revealed the extensive prevalence and diversity of plasmids in the human gut microbiome and discusses the challenges in accurately reporting plasmid genomes identified from metagenomic data.

This Genome Watch highlights the advances made in bacterial single-cell RNA sequencing, specifically in the context of host–microorganism interaction studies.

This month’s Genome Watch highlights the use of genetic barcoding towards a better understanding of plant–microorganism interactions and colonization dynamics.

This Genome Watch article discusses the application of sequencing methods for monitoring the rise of infectious diseases associated with climate change.

This Genome Watch article highlights the recent use of large-scale monitoring of natural microbiomes to examine feedback between environmental change and microbial adaptation.

Wastewater genomic surveillance can transform global viral disease monitoring. This Genome Watch article explores the techniques, analytical pipelines and implications for public health.

This month’s Genome Watch discusses the application of spatial transcriptomics to investigate the arrangements of microbial communities and their effects on the host.

This Genome Watch article highlights how studying pathogens in the context of their phylogenetic neighbours can provide insights into their evolution.

This month’s Genome Watch highlights the recent use of machine learning to uncover functional ‘dark matter’ in the microbial protein universe.