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Showing 1–4 of 4 results
Advanced filters: Author: Bing-Xin Hu Clear advanced filters

  • Glycosylated asparagine residues that mediate the function of the B7H3 protein are unclear. Here the authors identify the important N-glycosylation sites for B7H3 cell surface localization and T cell inhibition, followed by the development of N91/309 and N104/322 preferentially targeting monoclonal antibody manifesting enhanced antitumor immunity.

    • Yun Huang
    • Wen-Qing Zhong
    • Rong Deng
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits the plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and promoting ferroptosis propagation.

    • Hai-Liang Zhang
    • Yi-Qing Guo
    • Xiao-Feng Zhu
    Research
    Nature Chemical Biology
    P: 1-13

  • B7H3 is a transmembrane B7 family checkpoint molecule present on many cancer cells. Here the authors show that FUT8 mediates fucosylation of B7H3 to limit the immune response to triple-negative breast cancer as a potentially targeted mechanism of non-responsiveness to current checkpoint therapies.

    • Yun Huang
    • Hai-Liang Zhang
    • Rong Deng
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Through CRISPR–Cas9 and kinase inhibitor screening, Zhang et al. show that PKCβII phosphorylates and activates ACSL4 to enhance polyunsaturated fatty acid-containing lipid biosynthesis, thereby promoting accumulation of lipid peroxidation and ferroptosis.

    • Hai-Liang Zhang
    • Bing-Xin Hu
    • Xiao-Feng Zhu
    Research
    Nature Cell Biology
    Volume: 24, P: 88-98