Search

Integrated optical frequency combs are powerful tools for optical spectroscopy. Here, authors demonstrate low-power, detectable-rate soliton microcombs from telecom to visible bands, including wavelength-multiplexed operation, using ultra-low-loss silicon nitride waveguides.

This study identifies monoclonal antibodies A138 and B026 targeting MPXV proteins M1R and B6R. Both antibodies exhibit neutralization of MPXV and VACV, and their combination enhances protective efficacy in mice, supporting a dual-targeting strategy.

Trained on large and multicenter datasets with different imaging modalities, a foundation model is shown to have strong performance on the full spectrum of clinically relevant tasks and to increase user accuracy in diagnostic tasks.

Rhine et al. find that neuronal aging leads to widespread dysregulation of RNA biology, including mislocalization of splicing proteins like TDP-43, chronic cellular stress and reduced resiliency.

Materials with tunable modulus, viscosity, and complex viscoelastic spectra are crucial in various applications but it remains challenging to design polymer networks with predicted hierarchical relaxation processes. Here, the authors synthesize networks with both pendant and telechelic architectures using mixed orthogonal dynamic bonds to understand how the network connectivity and bond exchange mechanisms govern the overall relaxation spectrum.

Achieving sustainability in wireless communications is crucial yet poses significant challenges. To address this, the authors propose and demonstrate a solar-powered programmable metasurface enabling hybrid light-to-microwave wireless communications.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Guided bone regeneration (GBR) membranes are used to treat bone defects, but face challenges in regulating the immune microenvironment. Here, Yang et al. report a Janus collagen-based barrier membrane that modulates the osteoimmune microenvironment to effectively promote bone regeneration.

Climate-driven warming affects the reproduction of oviparous ectotherms. Here, authors identify and characterize a VtgR-mediated heat protection mechanism for oocyte development in both mud crabs and zebrafish.

Thermosetting polymers are widely used in 3D printing owing to their superior mechanical stability, but once they are printed, the highly crosslinked polmyers cannot be reprocessed or repaired. Here the authors demonstrate a two-step polymerization strategy toward 3D printing of reprocessable thermosets.

The treatment of poorly differentiated thyroid cancer and anaplastic thyroid cancer remains challenging. Here, the authors perform multi-omic analysis of thyroid samples and identify proteomic clusters associated with distinct tumour microenvironment features.

Integrating static image capture and dynamic visual processing in a single sensor is challenging. The authors experimentally demonstrate a CMOS-integrated organic neuromorphic imager with adjustable memory, capable of high-resolution dual-modal imaging.

Qi et al. show that bile acids produced by the gut microbiota can suppress platelet activation and reduce atherothrombosis, protecting atherosclerotic mice from myocardial ischemia/reperfusion injury.

Rising demand for ruminant meat and dairy products in developing nations drives increasing GHG and ammonia emissions from livestock. Authors show here that only long-term adoption of global best-practice in sustainable intensification buffered by a short-term coping strategy of green-source trading can offer a way forward.

Developing heat-resistant dielectric polymers for electrification is challenging due to the inverse relationship between thermal stability and electrical insulation. Using a machine learning-driven approach, the researchers identify and validate high-performance polymers that demonstrate promising thermal resilience and energy density for high-temperature applications.

There has been much interest in using skyrmions for new approaches to compution, however, creating, deleting and driving skyrmions remains a challenge. Here, Wang et al demonstrate all three operations for skyrmions in tailored Co8Zn10Mn2 nanodevices using tailored current pulses.

Realizing conversion between microwave and optical signals in free space is a challenge. Here, the authors propose and demonstrate a programmable metasurface that can achieve wireless microwave-laser interconversion for bidirectional air-water cross-media wireless communications.

Lipid biosynthesis in the pathogen M. tuberculosis depends on biotin for posttranslational modification of key enzymes. Here, Qu et al. identify an auxiliary protein that is required by M. tuberculosis to synthesize biotin.

By measuring the thermal properties of eclogite at high pressures, the authors found that temperature of orogenic continental crust is sufficient to melt granite and phengite, leading to low-velocity and high-conductivity anomalies in orogenic belts.

In vitro biosynthetic analysis reveals that a single trans-AT polyketide synthase (PKS) module iteratively enables five rounds of polyketide elongation and interacts with both the preceding and succeeding PKS enzymes to produce the 17-membered macrocyclic polyketide chejunolide.

The occupied anti-bonding states at the Fermi level in metavalently bonded systems stems from the interplay between metavalent bonds and the phase of orbitals. This provides a recipe for identifying superior dopants to improve the thermoelectric performance of metavalently bonded materials.

β-Lactone-containing natural products are rare. Now, a polyketide with a unique cyclopentane–β-lactone skeleton is reported. The key enzymes identified for the formation of the bicyclic core are a non-ribosomal peptide synthetase-like module with a β-lactone ring forming esterase and peptidyl carrier protein, thioester reductase and condensation domains.

Lung cancer screening (LCS) requires effectively and efficiently mining big, multimodal datasets. Here, the authors develop a medical multimodal-multitask foundation model (M3FM) for LCS from 3D low-dose computed tomography and medical multimodal data, outperforming state-of-the-art methods and allowing the identification of informative data elements.

Streptoseomycin is a potent antibiotic that contains a pentacyclic 5/14/10/6/6 ring system. Here, the authors report the enzymatic and non-enzymatic steps of the downstream modification of streptoseomycin biosynthesis and show a [6 + 4]-cycloaddition adduct as an unexpected biosynthetic intermediate.

Macrocyclization is an important process in bioactive natural product synthesis. Here, the authors report on the study of a macrocyclic ring constructing enzyme in the biosynthesis of alchivemycin A and using gene deletion, biochemical assays and isotope labelling show the enzyme catalyses tandem dehydration and Michael-type addition.

The mitochondrial unfolded protein response is shown to inhibit pluripotency during somatic cell reprogramming and to inhibit the mesenchymal-to-epithelial transition through c-Jun-mediated histone acetylation.

Synthetic cells mimicking the viscoelastic and T-cell-activation properties of antigen-presenting cells provide substantial enhancements in the expansion and potency of engineered human cytotoxic T cells.

A noise-tolerant LiDAR approaching the standard quantum-limited precision through photon-number resolving detection and active photon-number filter.

Site-specific and efficient RNA editing is achieved with a CasRx editor.

By engineering the crystallization process of Sn–Pb mixed perovskite films, all-perovskite tandem solar cells fabricated using an antisolvent-free method deliver a certified power conversion efficiency of 28.87% and retain 87% of this efficiency after 450 h of operation.

The logical rotation of non-separable states with a large tunable range is demonstrated by the uniformly self-assembled chiral superstructures, which enables a set of logic gates, proof-of-principle logic network, and angular motion tracking.

The histone deacetylase HDAC6 is a sensor of valine levels, and the abundance of valine in cells regulates DNA damage and cell homeostasis functions.

The dalesconol natural products are biosynthesised in an enantiomeric excess of 67%, rather than as a single enantiomer or a racemate. Tanet al. report that this unusual enantioselectivity is a result of the dominance of particular conformers of naphthol dimer intermediates.

Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.

RNA molecules exhibit conformational fluctuations between ground states and excited states. Here the authors designed and verified small hairpin RNAs with predefined secondary structure reshufflings. In light of Van’t Hoff analysis and accelerated molecular dynamics simulation, a mechanism of multistep sequential transition has been revealed.

Insights into the behavior of quantum materials are only possible because of the development of suitable experimental probes. Modic et. al. develop the theoretical and experimental basis for resonant torsion magnetometry—a technique to measure anisotropic magnetic responses with high sensitivity.

Graded-energy-gap lead sulfide/mercury telluride stacked quantum dots enable photodetection and imaging in a focal plane array configuration from the visible (0.4 µm) to the mid-wave infrared (about 5 µm) region.

Thick panel origami holds great potential in engineering structures, but conventional fabrication processes limit their design and applications. Here the authors report a multimaterial 3D printing-based design and fabrication strategy for thick-panel origami structures with push-to-pull deformation.

Mechanisms underlying the pathogenesis of nonalcoholic steatohepatitis are unclear. Here, the authors show that ROS-mediated DUSP22 degradation participates in the progression of fatty liver, contributing to the development of NASH and associated HCC via regulating FAK and its downstream ERK1/2 and NF-κB signaling cascade.

Single-cell transcriptome profiling of human aneuploid blastocysts highlights global transcriptomic alteration and identifies novel dosage-sensitive genes in aneuploidy. Aneuploid embryos undergo unstable epiblast maturation caused by defects in the TGF-β and FGF pathways that impact trophectoderm progression.

Two monoclonal antibodies isolated from a patient with COVID-19 are shown to interfere with SARS-CoV-2–receptor binding, and one displays potent action against this virus in vitro and in a rhesus macaque model.

Immune evasion is a feature of HPV-positive head and neck squamous cell carcinoma (HNSCC). Here the authors report that a circular RNA, circE7, encoded by HPV promotes immune evasion in HNSCC by promoting downregulation of galectin-9.

Nonalcoholic steatohepatitis (NASH) is a heterogeneous disease with complicated pathogenesis. Here the authors identify that the E3 ligase TRIM26 confers protection against NASH development via suppression of CCAAT/enhancer binding protein delta (C/EBPδ).