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Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

Chen, Yang et al. present DreAM, the drug-elicitable alternative splicing module, which is responsive to risdiplam, to inducibly regulate adeno-associated virus vector-mediated transgene expression. Proof-of-concept applications in cardiomyocytes revealed its potential for future clinical use in improving cardiac recovery after myocardial infarction.

Estimates of effectiveness of SARS-CoV-2 vaccines against symptomatic infection from observational studies may be biased if testing rates differ according to vaccination status. Here, the authors use simulations to quantify the impact of this testing bias in retrospective cohort and test-negative study designs.

The authors investigate the response of Archaea to experimental warming in a tallgrass prairie ecosystem. Warming was linked to reduced diversity and convergent succession, with further links to changed ecosystem function. Stochastic processes dominated community changes but decreased over time.

Skeletal reorganizations are intriguing processes in chemical synthesis due to their mechanism, atom-economy and synthetic versatility. Herein, the authors describe a divergent skeletal reorganization of N-sulfonyl ynamides to thiete sulfones and propargyl sulfonamides.

Indole alkaloids are one of the largest alkaloid classes, proving valuable structural moiety in pharmaceuticals but the direct single-step synthesis with broad structural diversity remains challenging. Herein, the authors report a modular assembly of tetrahydrocarboline type of indole alkaloids from simple building blocks in a single step while showing broad compatibility with medicinally relevant functionality

It is extremely difficult to separate tritium from radioactively contaminated water. Here the authors introduce catalytic hydrogen isotope exchange to water distillation, realizing excellent detritiation performance.

Cytochrome P450 enzymes (P450s) and their redox partner cytochrome P450 reductase (CPR) often perform poorly in bioproduction of natural products by engineered prokaryotic microbes. Here, the authors report spatial architecture-guided P450-CPR assembly for improving the biosynthetic performance of both plant and human P450s in E. coli.

The Mannich reaction is a three-component reaction for preparing alkylamines, but the nucleophilic components rely on C(sp²)−H and activated C(sp³)−H bonds. Here, the authors report an unprecedented multicomponent double Mannich alkylamination for both C(sp²)−H and unactivated benzylic C(sp³)−H bonds.

Global sampling of microbial communities associated with wastewater treatment plants and application of ecological theory revealed a small, core bacterial community associated with performance and provides insights into the community dynamics in this environment.

A platform for the continuous selection of protein aggregation inhibitors from genetically encoded cyclic peptide libraries in Escherichia coli was developed. This platform was used to discover cyclic peptides that suppress aggregation of amyloid-β42 and human islet amyloid polypeptide.

The authors report a Yin-Yang balance between α-Synuclein and β-Synuclein via regulating phase separation in physiological states and Parkinson’s disease. AI-designed peptides mitigate the symptoms and prolong the lifespan of C. elegans PD models.

The kink structure in the band dispersion can be linked to electron-boson interaction and has been reported in unconventional superconductors. Here the authors observe an orbital selective and momentum dependent kink feature in an Fe-based superconductor, which is highly correlated with superconductivity.

Mechanotransduction in endothelial cells is critical to maintain vascular homeostasis. Here, the authors show that the discoidin ___domain receptor 1 tyrosine kinase is a mechanosensor is essential for connecting the force imposed by shear to endothelial responses.

Mechanisms and consequences of the acclimation of soil respiration to warming are unclear. Here, the authors combine soil respiration, metagenomics, and functional gene results from a 7-year grassland warming experiment to a microbial-enzyme decomposition model, showing functional gene information to lower uncertainty and improve fit.

High drug loading improves therapeutic efficacy and reduces side effects in drug delivery. Here, the authors use controlled diffusion of solvents to precipitate drug nanoparticles in polymer particles while the polymer is solidifying and demonstrate the particles for drug delivery in a spinal cord injury model.

Using a multifactorial global change experiment, the authors show that warming grassland plots by +3 °C over 6 years accelerates the scaling rate of both taxonomic and phylogenetic diversity in soil bacterial and fungal communities.

The authors present ARPES and STM/STS measurements of the kagome superconductor CsV_3-xTa_xSb₅. For the x = 0.4 Ta-doped sample, they report evidence for a van Hove singularity perfectly aligned with the Fermi level, and that the superconducting transition temperature is maximized at this doping.

It is still under debate whether unconventional superconductors can still be described in terms of Bogoliubov quasiparticles in the superconducting state. Here, angle-resolved photoemission spectroscopy measurements on FeSe/SrTiO₃ films reveal particle-hole mixed Bogoliubov quasiparticles, despite the likely unconventional pairing mechanism.

Here, the authors exploit a non-invasive layer-bylayer etching technique to fabricate electronic devices based on 2D transition metal dichalcogenides with controlled thickness and transport properties comparable to those of exfoliated flakes.

Environmental and biotic factors control ecological communities. Here, the authors study community ribosomal rRNA gene copy number in coastal sediment and ocean bacterial communities, and in microcosm nutrient addition experiments, to propose a conceptual framework of how nutrient supply and ecological interactions shape the community.

Here the authors report binary phase supercritical lenses by patterning monolayer TMD materials. Through placement of atomic thin 2D TMD with sufficient absorption, a spot of critical coupling is created to facilitate a π phase jump and subdiffraction focusing over bandwidth of 150 nm in visible range.

Fullerenes are promising organic semiconducting materials for electronic applications, but of low conductivity due to limited intermolecular hybridization. Cui et al. show a black phosphorous substrate organizes C₆₀ monolayers to form delocalized semiconducting band with tens times enhanced conductivity.

A MoS₂ transistor with chiral nanocrescent plasmonic antennae enables the generation, propagation, detection and manipulation of valley information at room temperature.

Multiplexing orbital angular momentum states as independent and orthogonal information carriers for data encryption is realized through disorder-induced synthetic helical dichroism in disordered nanoaggregates.