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The zoonotic parasite Toxoplasma has complex developmental programs to accommodate different lifestyles that are important for parasite transmission and pathogenesis. Here, the authors discover a novel chromatin remodeling complex containing SNF2L in Toxoplasma and report its crucial roles in regulating the parasite’s developmental programs.

Treatment selection for recurrent hepatocellular carcinoma (rHCC) after hepatectomy remains challenging. Here, the authors develop HEROVision, a Vision Transformer-based model for personalised prognosis prediction and treatment optimisation in rHCC based on clinical and imaging data, outperforming other guideline staging systems and revealing patients who would benefit from changing treatments.

Molybdenum disulfide vertical transistors with channel lengths down to one atomic layer can be made with metal electrodes using a mechanical van der Waals transfer process that leads to a high-quality metal–semiconductor interface.

Fluorescence microscopy can be exploited to visualize and study T cell mediated cytotoxicity. Here the authors describe a high-throughput Bessel oblique plane microscopy platform for 3D imaging and phenotyping of cytotoxic CAR-T cells in co-culture with cancer cells.

The limited durability of metal-nitrogen-carbon electrocatalysts hinders their use in proton exchange membrane fuel cells for the oxygen reduction reaction. Here the authors transform active sites from FeN4 to stable monosymmetric FeN2 + N’2 via chemical vapor modification, resulting in enhanced improving the durability of the catalyst.

Multivalent antigen display on nanoparticles can enhance the immunogenicity of vaccines targeting viral moieties. Here the authors employ DNA origami to rationally design and assemble nanovaccines against SARS-CoV-2 and characterize cellular and humoral immune response in female mice.

Species-rich plant communities often have higher productivity than monocultures. Here, the authors analyse biodiversity-ecosystem functioning experiments in grasslands and forests and find that the biodiversity effects on community productivity strengthen over time thanks to shifts in contributions of species with different resource acquisition traits.

Hypercompact CRISPR-Cas12f systems have been engineered to generate miniABEs but these have limitations. Here the authors generate Cas12f-derived miniCBEs and develop miniABEs with improved editing and targeting scopes; they use these to correct pathogenic mutations in cell lines and introduce mutations in vivo.

Na et al. identify KMT2C deficiency as a driver of small cell lung cancer metastasis and demonstrate that it leads to epigenetic reprogramming through histone and DNA hypomethylation by upregulating DNMT3A.

Zhang and colleagues found that Omicron RBD binding to Siglec-9 impaired phagocytosis and antigen presentation in macrophages, an effect abrogated by an F375S mutation in the spike protein of Omicron.

Understanding the molecular changes in the transition from esophageal squamous precancerous lesions (ESPL) to esophageal squamous cell carcinoma (ESCC) remains essential. Here, the authors analyze ESPL samples using spatial transcriptomics and reveal expression changes in TAGLN2 and CRNN during progression to ESCC.

The authors show that an mRNA-based T-cell-inducing antigen combined with the receptor-binding ___domain of the SARS-CoV-2 spike protein strengthens the COVID19 vaccine against SARS-CoV-2 variants, suggesting improved vaccine designs that comprehensively stimulate both humoral and cellular responses.

This study reveals an unrecognized role of ABHD5 in regulating colon cancer stemness via controlling YAP methylation and nuclear localization, further explaining the molecular mechanism through which ABHD5 functions as a tumour suppressor gene in colon cancer.

R-spondin 2 has an important role in development but its function in cancer has not been described. In this study, Wu et al. demonstrate that R-spondin 2 is decreased in expression in colorectal cancer and this is associated with promoter methylation and inhibition of Wnt signalling.

Properties of cytidine and adenosine deaminases lead to off-target effects for cytosine base editors (CBEs) and adenine base editors (ABEs). Here the authors report that 25 TadA orthologs could be engineered to generate functional ABEs, CBEs or ACBEs via single/double mutations with minimised off-targets.

Here, using proteomics, molecular biology and sequencing, the authors demonstrate that OGT-dependent O-GlcNAcylation of H4S47 is important for replication-origin activation, presumably through regulating DDK-induced phosphorylation of the MCM complex.

A deep-learning-based ‘organelle segmentation network’ (OrgSegNet), performing pixel-wise segmentation to identify various organelles, is an innovative tool for plant organelle phenotyping and 3D cell reconstruction.

Rad5 is a hub connecting three replication stress tolerance pathways. Here, the authors present the 3.3 Å crystal structure of a N-terminal truncated K.lactis Rad5 construct that reveals the spatial arrangement of the HIRAN, Snf2 and RING domains and structure-guided in vitro and in vivo experiments reveal multiple activities of the yeast Rad5 HIRAN ___domain among them a role in binding PCNA and supporting its ubiquitination.

Using Lorentz transmission electron microscopy, one of the first direct observations of topological spin texture is described, in the pseudogap phase of a high-temperature cuprate superconductor based on YBa₂Cu₃O_6+x.

The mechanisms underlying differential chemotherapeutic response to 5-fluorouracil are not fully known. Here, the authors show that ABDH5 regulates sensitivity to 5-fluorouracil in colorectal cancer by regulating lysosome function.

Ten-eleven translocation 1 (TET1) is a critical oncoprotein in AML. Here, the authors identify 2 compounds that target the binding of STAT3/5 specifically to the TET1 promoter, inhibiting its expression and AML cell viability.

UTX is a tumor suppressor gene located on the X-chromosome so it could potentially contribute to the cancer gender bias. Here the authors, using a mouse model of B cell lymphoma, show that UTX is a dosage sensitive tumor suppressor and may be responsible for some of the increased incidence and possibly aggressiveness of male cancers that harbour UTX mutations.

The development of suitable anode materials is essential to advance sodium-ion battery technologies. Here the authors report that alkaline earth metal vanadates are promising candidates due to the favorable electrochemical properties and interesting sodium-storage mechanism.

Carnitine palmitoyltransferase 1A is found to promote the growth and proliferation of ovarian cancer cells through regulating mitochondrial dynamics by succinylating mitochondrial fission factor at lysine 302.