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Tracing cellular changes in complex biological systems is challenging. Here, authors present a flexible framework that integrates multi-sample data with in-house algorithms to infer comparative and spatiotemporal cell-gene patterns, advancing understanding of cellular dynamics.

Ferroptosis plays an important role in response to radiotherapy and chemotherapy, however, the sensitivity of cancer cell to ferroptosis varies. Here, the authors show that ODC1-mediated polyamine synthesis induces ferroptosis and demonstrate the potential of targeting this axis by combining polyamine supplements with radiotherapy or chemotherapy in preclinical lung cancer models.

Ru-based materials are promising catalysts for oxygen evolution reaction in acidic condition, but their catalytic performance needs to be further improved. Here, the authors report Zn-RuO₂ nanowires with a Ru−Zn dual-site oxide reaction pathway with enhanced activity and stability for acidic oxygen evolution reaction.

Bimetallic zinc and gold porphyrin self-assembled into 2D nanosheets as nanoscale optoelectrodes. This design achieves exceptional photoelectric performance under visible one-photon and near-infrared two-photon excitation, enabling far-field optical modulation of single neurons.

Dietary restriction is one of the most effective ways to delay ageing. Here, the authors discover a highly conserved lipid metabolism gene functions through transcriptional regulation mechanisms to regulate proteostasis, lifespan and healthspan in response to low nutrients in C. elegans.

A Stereo-seq and scRNA-seq atlas of mouse liver in homeostasis and regeneration after partial hepatectomy identifies zonated genes, pathways, cell–cell interactions and gene regulatory networks. Functional validation finds that cooperation between TBL1XR1 and β-catenin activates hepatocyte proliferation.

The increase in detoxification gene expression is a common transcriptome marker for longevity interventions. Here, the authors show that nomilin extends lifespan and healthspan in animals through activation of PXR regulated detoxification functions.

The interaction between the carbon support, active sites, and ionomer is crucial for oxygen reduction reaction catalysts. In this study, the authors employed operando X-ray Absorption Spectroscopy to demonstrate that mesoporous carbon supports facilitate optimal ionomer-catalyst interactions, enhancing catalyst performance.

The domestic chicken Gallus gallus domesticus is a classic model for the study of folliculogenesis. Here the authors integrate multi-omics analyses characterizing the dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis.

Here, authors successfully fabricated a springtail-inspired nano-concave reentrant structured polystyrene (PS) membrane using electrospraying technology followed by lubricant dip-coating, which endowed the membrane with omniphobic properties.

Structured thermal armours on the surface of a solid inhibit the Leidenfrost effect, even when heated to temperatures in excess of 1,000 °C, pointing the way towards new cooling strategies for high-temperature solids.

A large-scale single-cell transcriptomic atlas of the non-human primate Macaca fascicularis encompasses over 1 million cells from 45 adult tissues.

During preclinical drug development, the ability of cancer cell lines to faithfully model human disease is important for identifying potential therapeutic strategies. Here, using transcriptomic datasets of over 1000 cell lines, the authors evaluate how representative each line is of its cancer type and present their cell line selection tool.

Nanoscale optoelectrodes hold the potential to optically stimulate individual neuron. Here, the authors form nanoscale capacitive optoelectrodes by incorporating zinc porphyrin into nanorods, coated by TiO2, a design that allows for far-field optical modulation of neurons with efficiency and negligible side effects.

Sustainable materials with circularly polarized room-temperature phosphorescence are desirable but challenging to design. Here, the authors report the development of thin films, based on cellulose nanocrystals and lignosulfonate, with circularly polarised room temperature phosphorescence.

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and is associated with limited treatment options. This study elucidates the role of KLHL17 in the development and progression of NSCLC using clinical samples and NSCLC cell lines. The results show that upregulated KLHL17 in NSCLC promotes the proliferation and migration of tumor by activating Ras/MAPK signaling pathway, and suggest that KLHL17 may be a novel therapeutic target for the treatment of NSCLC.

Membrane distillation is susceptible to thermal inefficiency and membrane wetting issues during seawater desalination. Here, authors design a MXene-engineered membrane that imparts efficient localized photothermal effect and strong water repellency, achieving sustainable freshwater production.

Heterogeneity in gene expression and epigenetic states exists across individual cells. Here, the authors develop scCAT-seq, a technique for simultaneously performing ATAC-seq and RNA-seq within the same single cell.

A comprehensive transcriptomic survey of the pig could enable mechanistic understanding of tissue specialization and accelerate its use as a biomedical model. Here the authors characterize four distinct transcript types in 31 adult pig tissues to dissect their distinct structural and transcriptional features and uncover transcriptomic variability related to tissue physiology.

Analysis of the genomes and spatiotemporal distribution of Yersinia pestis in Inner Mongolia, China, reveals its genetic diversity and dual transmission patterns, including localized short-distance spread and long-distance dispersals.

Genome sequencing of Chinese Yersinia pestis isolates spanning more than 60 years and covering two epidemics and "silent” cycles in-between reveal the phylogeographic and evolutionary background of these plague cycles.

Electrochromic properties of covalently bonded polyaniline-reduced graphene oxide/single walled carbon nanotubes nanocomposites. A high performance electrochromic material was prepared using polyaniline (PANI) and two different dimensional carbon nanostructures, single-walled carbon nanotubes (SWCNTs) and reduced graphene oxide (rGO) as the components. The covalent bond was introduced to interface between PANI and two carbon nanostructures to form a three-dimensional conductive network. Owing to the high electron conduction through directly connected covalent bond and loose molecular chain aggregation brought by two various dimensional carbon nanostructure, PANI-rGO/SWCNTs nanocomposites exhibit superior electrochemical and electrochromic properties (high optical contrast and short switching time) compared with PANI.