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Pei et al. overcome desorption of passivating molecules under photothermal stress in wide-bandgap perovskites and achieve perovskite/Cu(In,Ga)Se₂ tandem solar cells with a certified efficiency of 27.35%.

BMP signaling forms an intestinal gradient regulating villus length by balancing cell proliferation with apoptosis to optimize nutrient absorption efficiency across regions.

In plants and algae, isoamylases drive phytoglycogen-to-amylopectin conversion. Here, the authors show that ISA1 and ISA2 form a heterocomplex that coordinately trims glucan branches to promote starch granule formation, defining a key step in starch biosynthesis.

CRISPR systems are powerful tools for gene editing and diagnostics, but their regulation is challenging. Here, the authors present DNACas, a light-controlled method using photocleavable phosphorothioate DNA to modulate CRISPR activity, enabling precise gene editing and one-pot diagnostic detection.

Cross-linked polymers with covalent adaptable networks are reprocessed under external stimuli at high temperatures which might deteriorate their performance. Here, the authors introduce carbon dioxide responsive ionic clusters into covalent adaptable polymer networks to facilitate the exchange of dynamic bonds providing materials with a rapid recycling and good mechanical performance.

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Neural circuit mechanisms underlying feeding behavior regulation are not fully understood. Here authors provide quantitative mapping of the brain-wide input and output configuration of tuberal nucleus somatostatin neurons, a key player of feeding regulation, in mouse brain for a deeper understanding of the feeding regulation network.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

The heterogeneity of HSPCs in response to IR stress remains poorly characterized. Here, the authors provide insights into the molecular intricacies of IR-induced BM injury and reveal the roles of BMP4-BMPR2 signaling in radiation resistance of HSCs.

Cell migration in confined environments is initiated by a cytoplasmic pool of anillin and Ect2 that promotes RhoA/myosin II-mediated activation at the poles of migrating cells, in a process dependent on the extracellular environment stiffness.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

First-instar orchid mantis nymphs avoid predators by mimicking black-red assassin bugs, whereas those in later instars avoid predators and attract prey by camouflaging themselves as lighter-coloured flowers. Here the authors use developmental transcriptomics, evolutionary genomics and predation experiments to reveal that this ontogenetic colour change is regulated by a pigment transporter called Redboy that emerged in Polyneoptera 284–197 million years ago.

Ultrafast magnetic resonance spectroscopic imaging enables non-invasive high-resolution metabolic imaging of the whole human brain under healthy and diseased conditions.

Early detection of electrical degradation in dielectric polymers is crucial but remains challenging. A general strategy of blending the polymer with chromogenic molecules is reported, which generates a visually discernible colour change as chemically activated by oxygen radicals generated in situ, indicating the early stage of electrical degradation in polymers.

Quasi-periodic oscillations from black holes (BHs) in flux have been reported in radio, optical, X-ray and gamma-ray bands, but there hasn’t been any report of quasi-periodic variations in polarization yet. Here, the authors show detection of GHz-band radio polarization oscillations from fast-rotating BH X-ray binary GRS 1915+105

The implementation of asymmetric Heck/cross coupling cascades of highly flexible haloalkene substrates remains a challenging and long-standing goal. Here the authors report an asymmetric domino Heck/Tsuji−Trost reaction of flexible vinylic halides with 1,3-dienes enabled by palladium catalysis.

The authors report on a 2D anion-rich NaCl₂ crystal with a Na:Cl ratio of approximately 1:2, which exhibits room-temperature ferromagnetism originating from the spin polarization of electrons in the Cl elements of these crystals.

Knowledge about the fate control of GABAergic neuron subtypes during development and pathogenesis is limited. Here authors reveal Foxg1 regulates transcriptional programs that direct lineage bifurcation.

Adapting their Pace of Aging method across two population studies of older adults, Balachandran and colleagues find that a faster aging rate puts older adults at risk for early onset of disability and dementia, and shortened lifespan.

This work achieves a flexible organic ferroelectric crystal with interesting plasticity by implementing fluorination on anion, making it a competitive candidate for flexible and wearable devices.

A facile light-triggered doping strategy involving a series of inactive photoactivable dopants is described that facilitates tunable regionally controlled n-doping of organic semiconductors, resulting in stable patterning of the doping profile at record high resolutions.

Salmonella is a major cause of foodborne disease worldwide. Authors created a Salmonella database and present a genetic atlas of antimicrobial resistance, identifying some socioeconomic and environmental drivers for the rise of resistance globally.

A platform for profiling single-cell density reveals insights into the regulation of cell density homeostasis and patient drug responses.

Wildfires are becoming increasingly frequent in several regions around the world due to climate change, posing serious health risks, especially for respiratory diseases. This study examines the respiratory health risk and burden of wildfire-specific PM_2.5 pollution across eight countries and territories.

Responsive materials have significant application value because of their ability to actively adjust their structure or properties in response to external stimuli. We employed polymerization-induced self-assembly combined with in situ crosslinking to synthesize stabilized thermoresponsive micelles, such as poly(glycerol methacrylate)-b-poly(N-isopropylacrylamide)-B, which exhibited rapid and reversible self-assembly. Furthermore, these micelles demonstrated excellent friction-reducing and wear-resistant properties showcasing their adaptive lubrication as additives. This work presents the facile fabrication of thermoresponsive micelles and expands the application of PISA technology in the tribological field.

Honeybee behavioral plasticity provides a model to study how brain gene networks regulate behavior. Here, authors show stripe activation in Kenyon cells links gene regulatory networks to behavioral maturation via spatial-cellular coordination.

This study utilizes Stereo-seq to comprehensively map the geospatial architecture of breast cancer, revealing venular niches that promote immune infiltration and better clinical outcomes, offering new insights into tumor microenvironment regulation.

Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the variation in clonal architecture within and between individuals.

Analysis of the 'Chicago' Archaeopteryx, a nearly complete and uncrushed specimen, reveals details of the skeleton, soft tissues and plumage of this taxon, providing information on the evolution to avian dinosaur.

An orally delivered encapsulated bacterial cocktail that metabolizes blood nitrogenous waste products in the gut reduces urea and creatinine concentrations in the blood of animal models of acute and chronic kidney injury.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

The authors report better toughness in n-type Ag₂Se than commercial Bi₂Te₃. The fabricated n-Ag₂Se/p-Bi₂Te₃ modules show good performance and long-term stability for both refrigeration and power generation near room temperature.

The high performance of two-dimensional (2D) channel membranes is generally achieved by preparing ultrathin or forming short channels with less tortuous transport through self-assembly of small flakes. Here, the authors report the construction of vertical channels in graphene oxide membranes based on a substrate template with asymmetric pores demonstrating high flux and metal ion rejection.

Chemical approaches to improve aqueous dispersions of conjugated polymers are limited by the feasibility of modifying the backbone or lead to poor performance. Here, Liu et al. show that ground-state electron transfer in donor:acceptor blends aids aqueous dispersion, for high conductivity and solubility.

Cell fate decisions remain poorly understood at the molecular level. Here Ming et al. show that BMP4 as the signal diverting cell fate away from epiblast/pluripotency to hypoblast/primitive endoderm fate during JGES reprogramming by promoting the dissociation of SALL4 from NuRD.

Glioma is a complex disease, and prognosis can depend on clinical, genomic and radiological information. Here, the authors develop a multimodal fusion subtyping model to integrate data modalities for predicting glioma subtypes.

Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive oxygen species signals.

Using 300 million hospital records from eight countries and territories, this study found that exposure to floods was associated with increased risks of hospitalizations for all causes considered: cardiovascular diseases, respiratory diseases, infectious diseases, digestive diseases, mental disorders, diabetes, injury, cancer, nervous system disorders and renal diseases.