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Genomic analyses of DNA from modern individuals show that, about 800 years ago, pre-European contact occurred between Polynesian individuals and Native American individuals from near present-day Colombia, while remote Pacific islands were still being settled.

Early breast cancer is often responsive to treatment, however, long-term prognosis is variable. Here, the authors utilise a deep learning model to predict metastasis free survival using digitised tumour slides.

The microbiomes associated with reef corals are complex and diverse. Here, the authors investigate fire coral clones naturally occurring in distinct habitats as a model system to disentangle the contribution of host genotype and environment on their microbiome, and predict genomic functions based on taxonomic profiles.

This study shows that glial reactivity is linked to synaptic dysfunction in aging and Alzheimer’s disease, with tau pathology mediating these effects–highlighting the potential of synaptic biomarkers track disease progression.

In this cross-sectional study, the authors used structural MRI to compare subcortical volumes, cortical thickness and surface area between early-onset anorexia nervosa, avoidant/restrictive food intake disorder and typically developing young individuals.

Mendes and colleagues present SReD, an unsupervised tool that detects repetitive biological structures in microscopy images. It works across imaging modalities and reveals patterns in viral assembly and cytoskeletal dynamics, thus enabling unbiased structural analysis.

Carbon nanotubes are promising hosts for spin qubits, however existing demonstrations show limited coherence times. Here the authors report quantum states in a carbon-nanotube-based circuit driven solely by cavity photons and exhibiting a coherence time of about 1.3 μs.

In situ cryoEM and modelling of the Campylobacter jejuni flagellar motor characterize the periplasmic scaffold and the structural basis for increased torque generation.

Wastewater surveillance is used to monitor pharmaceuticals related to respiratory diseases in parallel with four respiratory viruses. The results demonstrate the potential of pharmaceutical surveillance to assess emerging public health threats.

This study reveals that CO₂-concentrating mechanism (CCM) and photorespiration operate jointly in green algae, challenging the long-held belief that photorespiration is suppressed by CCM, reshaping our understanding of algal physiology and carbon metabolism.

Huot et al. investigate the differences in natural killer (NK) cells in lymph nodes during pathogenic and nonpathogenic simian immunodeficiency virus (SIV) infection of cynomolgus macaques and African green monkeys (AGMs), respectively. Their findings suggest that NK cells are specifically recruited to follicles in AGMs and regulate SIV replication in the lymph node.

Here the authors present a local ancestry inference algorithm with superior accuracy, and use it to shed light on the demographic histories of Latin Americans and the Askenazi Jewish, and to map a candidate Viking immune locus under selection in the British population.

Efficient sunlight-to-fuel conversion requires materials that produce long-lived charges, but increasing carrier lifetimes in visible-light-active photocatalysts has proven difficult. Now it has been shown that rapid charge deactivation via metal-centred states prevents long lifetimes and limits photocatalytic performance. These insights bridge solid-state and molecular photochemistry, informing strategies for improved photocatalyst design.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Analysis combining multiple global tree databases reveals that whether a ___location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Despite being an important driver of a subset of medulloblastomas, efforts to therapeutically target Sonic Hedgehog (SHH) signaling, such as with the use of Smoothened (SMO) inhibitors, have had limited success. Here, the authors find that SHH medulloblastomas are sensitive to netrin-1 inhibition and investigate netrin-1 as a mechanism of resistance to SMO inhibition.

How axolotl salamanders know what portion of the limb to regenerate remains a mystery. In this article, the authors show that precise retinoic acid degradation is critical for instructing regeneration of the appropriate limb segment.

Bacterial cell division depends on the dynamic assembly of FtsZ proteins, forming the Z-ring. Here, the authors show that the N-terminal intrinsically disordered region of FtsZ functions as a cis-acting disassembly element and is essential for Z-ring condensation at midcell in E. coli cells.

TUG protein localizes to the endoplasmic reticulum-Golgi intermediate compartment, forms biomolecular condensates, and organizes and stabilizes these membranes to support their function in diverse secretory and degradative trafficking pathways.

Analysis of data from multiple instruments reveals a giant exoplanet in orbit around the 0.2-solar-mass star TOI-6894. The existence of this exoplanetary system challenges assumptions about planet formation and it is an excellent target for atmospheric characterization.

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

In a cluster-randomized trial conducted across 70 medical centers in six countries, a 16-week structured educational program for healthcare providers improved adherence to guidelines for rhythm control but not for stroke prevention in individuals with atrial fibrillation.

Here the authors characterize a single-___domain antibody that broadly neutralizes SARS-CoV-2 variants with high potency by targeting the heptad repeat 2 (HR2) coiled coil, conserved in sarbecoviruses. Binding to its quaternary epitope blocks membrane fusion, by locking HR2 in its prefusion conformation.

Agreement forged in Paris aims to hold warming ‘well below’ 2 °C.

We present atom interferometry performed in a laboratory-scale Einstein Elevator over several days with high reproducibility. This table-top experiment enables long-term metrological assessments of quantum inertial sensors in microgravity.

Eriksson et al. reveal how the electricity-water nexus impacts public health across Latin America and the Caribbean, where drought-induced shifts from hydropower to combustion plants worsen air quality, causing thousands of deaths per year.

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Quantum emitters have recently been identified as efficient sources of graph states, which are entangled states crucial for photonic quantum computation. Here the authors demonstrate deterministic and reconfigurable generation of caterpillar graph states using a semiconductor quantum dot in a cavity.

The sub-continental lithospheric mantle passively degasses volatiles to Earth’s surface, including from regions unaffected by volcanism, according to a study of helium and argon isotopes in young groundwater.

The Mass Spectrometry Query Language (MassQL) is an open-source language that enables instrument-independent searching across mass spectrometry data for complex patterns of interest via concise and expressive queries without the need for programming skills.