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Polyethylene glycol (PEG) is used in many nanomedicines but might cause the production of anti-PEG antibodies. This Review critically assesses mechanisms and effects of PEG immunogenicity and explores strategies to address PEG immunogenicity in the context of nanomedicine.

Some individuals develop antibodies against the polyethylene glycol that is commonly used in therapeutic preparations. Here the authors conduct a GWAS in Han Chinese and find the IGH locus is associated with anti-PEG IgM.

A zeolite-confined Cu single-atom cluster was developed for the electrochemical CO reduction application, which can achieve stable CO-to-acetate conversion at an industrial current density of 1 A cm⁻² at 2.7 V with a high acetate Faraday efficiency for over 1,000 h at atmospheric pressure.

A RuNi/NC catalyst with optimized interfacial water dynamics for alkaline H₂ evolution is reported. The designed strategy shows enhanced catalytic activity by achieving 12 mV overpotential at 10 mA cm^‒2 and 13.6-fold higher mass activity than Pt/C.

Monitoring the biology of nucleoli remains challenging, particularly in the case of suspended cells and in high-throughput applications. Here, the authors report single-cell laser emitting cytometry, which can profile nucleoli in single cells and tissues in a label-free manner.

Here the authors show that human telomerase biogenesis involves LARP3, LARP7, and MePCE mediating the maturation of human telomerase RNA. This study provides insights into the pathogenesis of LARP3 and LARP7/MePCE deficiencies.

Solid-state lithium batteries typically utilize heterogeneous composite cathodes with conductive additives, which limit energy density and cycle life. Here the authors present a cathode material that exhibits efficient mixed conduction and near-zero volume change during cycling, thereby improving battery performance.

Near infrared energy remains untapped toward the maneuvering of entire solar spectrum harvesting for fulfilling nuts and bolts of solar hydrogen production. Here, the authors report the use of Au@Cu₇S₄ yolk@shell nanocrystals for hydrogen production from untapped near infrared energy.

Adjuvant gefitinib improves outcomes in non-small cell lung cancer (NSCLC) patients compared to chemotherapy, but not in all cases. Here, the authors find genomic biomarkers of response to gefitinib in NSCLC patients from the ADJUVANT trial, and propose a score to stratify them by potential benefit from the treatment.

The Zhang-Rice singlet is known for the superconductivity of high-temperature superconductors cuprate but is rarely studied for an electrochemical catalyst. Here, the authors use operando spectroscopic tools and observe Cu active site evolves into high-valent CuO₄ geometry with Cu³⁺ active species, so-called Zhang-Rice singlet state, during oxygen evolution reaction.

Lattice-oxygen redox is pivotal for high oxygen evolution reaction (OER) activity. Here, LiNiO₂, a unary 3d-transition metal oxide catalyst, exhibits superefficient activity during the OER due to the creation of double O 2p holes states, according to operando XAS, XRD, and Raman spectroscopy observations.

Efficient electrocatalysts are crucial to the electrochemical carbon dioxide reduction. Here, the authors use the fast operando technique to explore a silver-based catalyst with improved catalytic performance benefiting from the suitable defect structures.

Water oxidation catalysis may provide the electrons needed for sustainable fuel production, but catalysts often degrade under working conditions. Here, authors introduce soluble species into perovskites to exert positive ion leaching effects for enhancing perovskite stability and activity.

Long noncoding-RNAs have been linked to hepatocellular carcinoma (HCC) and some can be used as prognostic markers. Here the authors, by analysing RNA-seq in 60 clinical samples from 20 patients, provide a resource of functional lncRNAs and biomarkers associated with HCC tumorigenesis and metastasis.

The state of a superconducting circuit qubit governs the photonic heat flow through an integrated assembly, constituting a quantum heat valve that provides a testbed for exploring quantum thermodynamics in a circuit quantum electrodynamics setting.

Determining catalyst electronic structures during electrochemical reactions is crucial to understand mechanisms. Here authors perform in operando soft X-ray spectroscopy on a cobalt oxide catalyst during O₂ evolution and observe voltage and time-dependent valence state transitions.

Splitting water using suspensions of particulate carbon nitride-based photocatalysts may be a cheap way to produce hydrogen, but efficiencies have remained low. Now, Shen and colleagues use doped carbon nitride-based Z-scheme heterostructures to split water with a solar-to-hydrogen efficiency of 1.1% in the presence of metal-based co-catalysts.

Aluminium offers an attractive alternative anode for lithium-ion batteries, but its practical performance falls far short of the theoretical promise. Here, the authors present a yolk-shell structured nanocomposite anode of aluminium core and titanium oxide shell which displays outstanding electrochemical properties.

Collagen is a dynamic component of both the tumor and metastatic niche. Here, the authors show that airway smooth muscle cells are a collagen III rich niche bladder cancer cells expressing CD167a, and Stat3 is a downstream target for abrogating  these collagen III/CD167a-driven metastatic foci.

A scanning laser-emission-based microscope enables submicrometre-resolution mapping of nuclear biomarkers and the diagnosis of early-stage lung cancer in tissue samples from patients.

The majority of treatment options for cancers are ineffective due to limited therapeutic targeting. Here, the authors develop bispecific antibodies that effectively target nanomaterials to triple-negative breast cancer cell receptors and deliver therapeutics leading to inhibition of tumour growth.

Microtubule asters originate from centrosomes but their role during interphase remains largely unknown. Here, the authors find that microtubule asters anchored by previously-uncharacterized FSD1 play a role in ciliogenesis by maintaining the dynamic localization of centriolar satellites.

The Editorial Board and Editorial Team are delighted to present a selection of short Research Highlights describing some of our favourite Communications Engineering publications of 2023.

Self-assemble introduction of α-glucan contained block copolymer materials into the particular layer of the memory devices have been impressed by their excellent performance. Some newly reported MH-based copolymer literatures in electronic application are discussed in this focus review, including the electron-trapping mechanism of oligosaccharide MH, the relationships between chemical structures and their supramolecules, self-assembly morphologies and the memory device characteristics of electronic devices. As a perspective, the glucose-based block copolymer materials have a great potential to develop into the greener generation for advanced green electronics.