Search

Gillian Beer reveals the currents in Lewis Carroll's worlds.

This study uses brain recordings, self-reports, and facial analysis to decode acute pain in epilepsy patients. Machine learning reveals stable neural markers in mesolimbic, striatal, and cortical regions, plus facial cues, enabling reliable pain detection in naturalistic settings.

The abundant production of (anti-)nuclei in relativistic heavy-ion collisions provides a platform to test the CPT invariance of nucleon–nucleon interactions—offering the highest precision measurement to date in the light-nuclei sector.

Measurements of the inelastic cross section of anti-³He allow the estimation of the transparency of the Milky Way to the propagation of these light antinuclei produced in either cosmic-ray collisions or annihilation of dark-matter particles.

Exploiting technologies derived from the optical clocks community, the authors demonstrate a setup for twin-field QKD which extends the coherence times by three orders of magnitude, overcoming the main challenge towards real-world implementation.

Here the authors develop a pipeline combining atomic force microscopy and deep learning to trace and quantify the structure of complex DNA molecules like replication intermediates and recombination products. Furthermore, they characterise surface deposition effects using simulations.

Probing endogenous protein localization and function in vivo remains challenging due to laborious gene targeting and monofunctional alleles. Here, using a toolkit consisting of genetically-encoded epitope probes, their cognate tags, and an array of adapter proteins, the authors describe a methodology that enables visualization and manipulation of endogenous proteins in vertebrate systems.

People use knowledge of social network structure—that is, popularity and distance—to strategically spread gossip. To achieve this, they draw on internal models that capture the cascading dynamics of information flow across ties in a network.

Cell migration in confined environments is initiated by a cytoplasmic pool of anillin and Ect2 that promotes RhoA/myosin II-mediated activation at the poles of migrating cells, in a process dependent on the extracellular environment stiffness.

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

The authors find cholinergic neurons regulate glymphatic waste clearance via neurovascular mechanisms, with their loss impairing this process. This finding suggests targets for diagnostics and treatment.

Green hydrogen production via water electrolysis requires a low-cost solution to provide efficient catalysts. Here, the authors report an industrially scalable method for synthesizing NiFe layered double hydroxide at room temperature and atmospheric pressure, enhancing alkaline electrolysis.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Antibodies against SARS-CoV-2 continue to evolve 6 to 12 months after infection in patients who have recovered from COVID-19, increasing in potency and breadth with time.

Structural, pharmacological and computational studies reveal how different classes of positive allosteric modulators bind to distinct allosteric sites and use noncanonical mechanisms to activate the free-fatty acid receptor FFA2.

The ability to encode and recall information about food is critical for survival. We reveal that ventral hippocampus projections to the lateral hypothalamus encode meal-related memories, and that disruption of this circuit promotes excessive eating.

The direct measurement of the QCD dead cone in charm quark fragmentation is reported, using iterative declustering of jets tagged with a fully reconstructed charmed hadron.

A soft mesh microelectrode array can seamlessly integrate in developing brains, enabling long-term, stable mapping of how single-neuron activity and population dynamics emerge and evolve during brain development.

Teplizumab is clinically approved for delaying the onset of type 1 diabetes, with the responses affected by EBV serology status. Here the authors pursue immune profiling of EBV⁺ or EBV^- participants before and after teplizumab treatment to find more pronounced immune modulation in treated EBV⁺ individuals to hint a cellular mechanism for this EBV effect.

It remains unclear why some paediatric tumours appear to have such a low mutation burden. Here, the authors shed light on this paradox by analysing Wilms tumours using high resolution and high depth sequencing approaches, finding that - due to an unusual clonal architecture - standard methods significantly underestimate the mutation burden at the cellular level.

Correlations in momentum space between hadrons created by ultrarelativistic proton–proton collisions at the CERN Large Hadron Collider provide insights into the strong interaction, particularly the short-range dynamics of hyperons—baryons that contain strange quarks.

This study reveals that global adoption of mass timber products can expand forestland, increase carbon stocks in forest and wood products, and decrease life-cycle greenhouse gas emissions.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

DNA interstrand crosslinks induced by acetaldehyde are repaired by both the Fanconi anaemia pathway and by a second, excision-independent repair mechanism.

Basidiomycete fungi typically have two mating-type loci located on different chromosomes. Here, Lucotte et al. report the convergent loss-of-function of mating-type genes across several species of phytopathogenic fungi of the genus Microbotryum.

Analysis of a fossil trackway from the earliest Carboniferous of Australia shows prints of toes with claws, suggesting that the origin of amniotes was at least 35–40 million years earlier than previously thought.

Nature Reviews Earth & Environment interviewed Associate Professor Supriya Mathew from Menzies School of Health Research about their project investigating the effects of extreme heat on First Nations people in remote Australia and ways to reduce the health risks.

Chromosome-level genome assemblies of nine tetraploid and two diploid wild Oryza species provide insights into genome evolution within the genus Oryza and the potential for crop improvement and neodomestication.

Microscopic colitis is a chronic inflammatory disease of the large intestine. Here the authors use single-cell RNA transcriptomic profiling and tissue localization studies to characterise the colon immune cell populations in MC, showing expansion of CD8 T cells with diverse TCR clonotypes and expression of CD4 T reg cell signatures.

Transcription-replication conflicts (TRCs) promote tumor aggressiveness by affecting genome stability. Here, the authors identify ANP32E as driver of TRCs in breast cancer, causing R-loop accumulation and genomic instability, which elicit vulnerability to ATR inhibition.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Analysis of snRNA genes in individuals with rare disorders identifies de novo and recurrent variants in RNU5B-1 and RNU5A-1, in addition to previously unreported cases with pathogenic or likely pathogenic variants in RNU4-2.

Vagus nerve stimulation (VNS) is emerging as a potential treatment for several chronic diseases. Here, the authors describe a VNS method using intermittent interferential current stimulation (i²CS) that allows precise control of organ-specific fiber activation in swine.

Hydroxylysine galactosylation is essential for collagen maturation. This work reveals the molecular structure of human GLT25D1, its catalytic residues, and a noncatalytic structural ___domain stabilized by metal ion and donor substrate binding.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Anthropogenic contaminants enter sea ice, with varied behavior depending on size (dissolved, colloidal, particulate) and particle density—providing insights into poorly understood incorporation mechanisms.

Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with specific mutations that form three stereotypical ecosystems.

In obesity, mitochondrial communication with the nucleus may be disrupted. Here, the authors use Finnish twin data to link obesity-related changes in mitochondrial DNA quantity with the methylation and expression of SH3BP4 in adipose tissue.

Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive heterogeneity and microenvironmental co-evolution.

The high precision of atomic sensors can be further enhanced by quantum correlations between atoms prepared in an entangled state through the use of artificial intelligence.