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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint

Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochromatin content and increased nuclear membrane tension.

Solène Hervé
Andrea Scelfo
Daniele Fachinetti
ResearchOpen Access08 Jan 2025
Nature Cell Biology

Volume: 27, P: 73-86
Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes

Dendritic cells experience cell shape changes while migrating within the complex physical environment of tissues. Sensing of these shape changes modifies their migratory properties and imprints these cells with immunoregulatory properties.

Zahraa Alraies
Claudia A. Rivera
Ana-Maria Lennon-Duménil
ResearchOpen Access04 Jun 2024
Nature Immunology

Volume: 25, P: 1193-1206

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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint

Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes

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