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Showing 1–7 of 7 results
Advanced filters: Author: Andrea Galmozzi Clear advanced filters

  • Protein phosphorylation plays critical roles in myriad cell processes. In this work, the authors apply new mass spectrometer technology to detect and quantify tens of thousands of protein phosphorylation sites within one hour or less of analysis. This technology has potential to greatly accelerate biological discovery.

    • Noah M. Lancaster
    • Pavel Sinitcyn
    • Joshua J. Coon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Signalling through the IRE1 arm of the unfolded protein response exerts both protective and harmful effects in obesity. Here the authors report that a selective pharmacologic activator of IRE1/XBP1s signalling stimulates an adaptive remodelling of liver and pancreas in diet-induced obese mice and mitigates obesity-linked systemic metabolic dysfunction.

    • Aparajita Madhavan
    • Bernard P. Kok
    • R. Luke Wiseman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • Progesterone receptor membrane component 2 is required to transport haem from the mitochondria to the nucleus, where, in adipose tissue, it has roles in regulation of thermogenesis and glucose metabolism.

    • Andrea Galmozzi
    • Bernard P. Kok
    • Enrique Saez
    Research
    Nature
    Volume: 576, P: 138-142

  • Activity-based protein profiling (ABPP) was used to identify and optimize bioactive, selective pharmacological enzyme activators of the serine hydrolase LYPLAL1, which improved the metabolic defects of diet-induced obese mice.

    • Bernard P. Kok
    • Srijana Ghimire
    • Enrique Saez
    Research
    Nature Chemical Biology
    Volume: 16, P: 997-1005

  • Phenotypic screening for serine hydrolase inhibitors capable of modulating lipid storage coupled with target deconvolution identifies carboxylesterase 3 as having a role in regulating adipocyte function, with enzyme inhibition causing positive outcomes in mouse models of obesity and diabetes.

    • Eduardo Dominguez
    • Andrea Galmozzi
    • Enrique Saez
    Research
    Nature Chemical Biology
    Volume: 10, P: 113-121