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Showing 1–20 of 20 results
Advanced filters: Author: Andy G. X. Zeng Clear advanced filters

  • Here the authors report asperigimycins, fungal ribosomally synthesized and post-translationally modified peptides with a heptacyclic scaffold. After chemically modifying them for nanomolar anticancer activity, CRISPR screening identifies SLC46A3 as a key transporter for their uptake in cells.

    • Qiuyue Nie
    • Fanglong Zhao
    • Xue Gao
    Research
    Nature Chemical Biology
    P: 1-10

  • Dick and colleagues identify human LT-HSC subsets with distinct quiescent states. They link these differences to INKA1-mediated downregulation of the transmembrane protein CD112 and its interaction with the protein deacetylase SIRT1. INKA1 is inversely correlated with the histone H4K16Ac mark, which then distinguishes ‘latent’ CD112lo LT-HSCs from CD112hi LT-HSCs that are more readily activated in response to hematopoietic stress.

    • Kerstin B. Kaufmann
    • Andy G. X. Zeng
    • John E. Dick
    Research
    Nature Immunology
    Volume: 22, P: 723-734

  • A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders.

    • Jeremy A. Miller
    • Song-Lin Ding
    • Ed S. Lein
    Research
    Nature
    Volume: 508, P: 199-206

  • Transcriptomic analysis of BCR-ABL1 lymphoblastic leukemia identifies three subgroups, each associated with a maturation arrest at a specific stage of B-cell progenitor differentiation and distinct genetic and clinical features.

    • Jaeseung C. Kim
    • Michelle Chan-Seng-Yue
    • Faiyaz Notta
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 1186-1197

  • Precise regulation of auxin concentration via transport and metabolism determines the developmental fate of plant tissues. Here the authors show that local auxin biosynthesis is regulated by TMK4-dependent phosphorylation of the TAA1 enzyme and that this is required for proper root development.

    • Qian Wang
    • Guochen Qin
    • Tongda Xu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • The Muscle Aging Cell Atlas presents approximately 200,000 single-cell and single-nuclei transcriptomes from 17 human donors across different ages, uncovering mechanisms of aging in muscle stem cells, myofibers and microenvironment cells, and demonstrates parallels in mouse muscle aging.

    • Veronika R. Kedlian
    • Yaning Wang
    • Hongbo Zhang
    ResearchOpen Access
    Nature Aging
    Volume: 4, P: 727-744

  • Comprehensive analyses of 178 lung squamous cell carcinomas by The Cancer Genome Atlas project show that the tumour type is characterized by complex genomic alterations, with statistically recurrent mutations in 11 genes, including TP53 in nearly all samples; a potential therapeutic target is identified in most of the samples studied.

    • Peter S. Hammerman
    • Michael S. Lawrence
    • Matthew Meyerson
    ResearchOpen Access
    Nature
    Volume: 489, P: 519-525

  • A consortium reports the tripling of the number of genetic markers in Phase II of the International HapMap Project. This map of human genetic variation will continue to revolutionize discovery of susceptibility loci in common genetic diseases, and study of genes under selection in humans.

    • Kelly A. Frazer (Principal Investigator)
    • Dennis G. Ballinger
    • John Stewart
    Research
    Nature
    Volume: 449, P: 851-861

  • This paper reports integrative molecular analyses of urothelial bladder carcinoma at the DNA, RNA, and protein levels performed as part of The Cancer Genome Atlas project; recurrent mutations were found in 32 genes, including those involved in cell-cycle regulation, chromatin regulation and kinase signalling pathways; chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far.

    • John N. Weinstein
    • Rehan Akbani
    • Greg Eley
    ResearchOpen Access
    Nature
    Volume: 507, P: 315-322

  • The authors developed an optimized rabies tracing system for generating brain-wide monosynaptic input connectomes, and applied it in mouse visual cortex to reveal topographically organized subnetworks co-defined by visual areas, layers and cell classes.

    • Shenqin Yao
    • Quanxin Wang
    • Hongkui Zeng
    Research
    Nature Neuroscience
    Volume: 26, P: 350-364

  • The Cancer Genome Atlas consortium reports on their genome-wide characterization of somatic alterations in colorectal cancer; in addition to revealing a remarkably consistent pattern of genomic alteration, with 24 genes being significantly mutated, the study identifies new targets for therapeutic intervention and suggests an important role for MYC-directed transcriptional activation and repression.

    • Donna M. Muzny
    • Matthew N. Bainbridge
    • Elizabeth Thomson.
    ResearchOpen Access
    Nature
    Volume: 487, P: 330-337

  • Sabeti et al. build on their This paper builds on previous work of detecting selection on human genes, using the many more markers available in the Phase II HapMap project. Three examples of apparent population-specific selection based on geographic area are described, and how these may relate to human biology is discussed.

    • Pardis C. Sabeti
    • Patrick Varilly
    • John Stewart
    Research
    Nature
    Volume: 449, P: 913-918