Nature Search

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

Physiological modelling of first-pass metabolism using data from a robotic instrument that fluidically links relevant organ chips predicts human pharmacokinetic parameters for orally administered nicotine and for intravenously injected cisplatin.

Anna Herland
Ben M. Maoz
Donald E. Ingber
Research27 Jan 2020
Nature Biomedical Engineering

Volume: 4, P: 421-436
Robotic fluidic coupling and interrogation of multiple vascularized organ chips

A system employing liquid-handling robotics and an integrated mobile microscope enables the automated culture, sample collection and in situ microscopy imaging of up to ten fluidically coupled organ chips within a standard tissue-culture incubator.

Richard Novak
Miles Ingram
Donald E. Ingber
Research27 Jan 2020
Nature Biomedical Engineering

Volume: 4, P: 407-420
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

Three linked microfluidic chips model transport across the blood–brain barrier.

Ben M Maoz
Anna Herland
Kevin Kit Parker
Research20 Aug 2018
Nature Biotechnology

Volume: 36, P: 865-874
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

In vitro blood-brain barrier (BBB) models do not fully recapitulate the in vivo barrier function. Here the authors develop an organ-on-a-chip BBB model using iPS-derived human brain endothelial cells differentiated under hypoxia, primary human pericytes and astrocytes, which maintains in vivo-like BBB barrier and shuttling functions for a week.

Tae-Eun Park
Nur Mustafaoglu
Donald E. Ingber
ResearchOpen Access13 Jun 2019
Nature Communications

Volume: 10, P: 1-12
Spatial control of membrane receptor function using ligand nanocalipers

Ligand nanocalipers made using DNA nanotechnology are used to display ephrin-A5 at well-defined spatial intervals to study how nanoscale ligand spacing affects EphA2 receptor activation in breast cancer cells.

Alan Shaw
Vanessa Lundin
Ana I Teixeira
Research06 Jul 2014
Nature Methods

Volume: 11, P: 841-846
Fluid interfacial energy drives the emergence of three-dimensional periodic structures in micropillar scaffolds

The revelation that fluid–fluid interfacial energy can drive structure formation in micropillar scaffolds offers a scalable way of synthesizing soft composites, which may have applications in building materials that mimic biological tissue.

Hiroki Yasuga
Emre Iseri
Wouter van der Wijngaart
Research22 Mar 2021
Nature Physics

Volume: 17, P: 794-800
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Amendments and CorrectionsOpen Access17 Mar 2021
Nature

Volume: 592, P: E8
LifeTime and improving European healthcare through cell-based interceptive medicine

The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Reviews07 Sept 2020
Nature

Volume: 587, P: 377-386

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