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Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.

R9AP is a key receptor for entry of Epstein–Barr virus into human epithelial and B cells, and interacts directly with the viral glycoprotein gH/gL complex to mediate virus–host membrane fusion.

The connection between plasma proteomic and brain structure remains unclear. Here, the authors establish a comprehensive atlas of the patterns of associations between microscale proteome and brain structure, and demonstrate their potential value for studying brain disorders.

Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

Structural and biochemical studies of the monkeypox virus core protease show that it exists as an active homodimer and indicate that the substrate-binding sites of core proteases are a promising target for antiviral drugs.

The mechanism of lipoprotein sorting to the bacterial cell surface is still unclear. Here, authors determine the crystal structures of paLptDE-LptM and apo-paLptDE, providing insights into how SLPs are transported to the cell surface via LptDE.

Inflammatory immune cells are found in the synovial fluid of patients with rheumatoid arthritis (RA). Here the authors use scRNA sequencing of synovial fluid cells from RA patients before and after treatment with adalimumab/tofacitinib and find changes in inflammatory SPP1+ macrophages and explore the function of these cells in mouse models.

In this study, multiple μ-spatially offset Raman spectroscopy is used to determine blood glucose levels noninvasively in humans, achieving comparatively high accuracy in a clinical setting.

Treating myocardial reperfusion injury via nanotherapy is challenging due to clearance by the mononuclear phagocyte system. Here, the authors target the spleen to reduce acute heart injury and improve long-term cardiac function via transient IRF7 inhibition.

Understanding base excision repair leads to the development of more efficient mitochondrial adenine editors.

Molecular self-assembly can be influenced by a number of external factors, though solvent effects are less commonly explored. Here, the authors present a three-armed metallopeptide complex that has a folded monomeric conformation in organic solvent, but can self-assemble in water into a supramolecular gel.

Oxidative stress is closely linked with nonalcoholic steatohepatitis (NASH). Here, the authors show that palmitic acid stimulates NASH by inhibiting PRDX1 to increase oxidative stress, while rosmarinic acid improves NASH by activating PRDX1 to reduce oxidative stress.

The oncoprotein ANLN regulates contractile ring assembly during mitosis, has been reported as an oncoprotein. Here, the authors report a role of nuclear ANLN in gene transcriptional regulation through interaction with RNA Pol II and promoting its clustering and phase separation.

Precise control of the growth of transition metal dichalcogenides layers in atomically thin van der Waals heterostructures has gained significant attention. Here, the authors report 100% overlapped vertical ReS₂/WS₂heterostructures by utilizing the twinned growth behaviour of two-dimensional materials.

The 4Pi-SIM microscope combines the benefits of structured illumination microscopy with 4Pi geometry for improved axial resolution, offering isotropic, multicolor super-resolution imaging of dynamic processes in living cells.

Abnormal angiogenesis is a key process associated with ischaemic retinopathies such as diabetic retinopathy, for which the underlying pathological mechanisms are still poorly understood. Here, the authors show that AGGF1/TNFSF12/FN14 signalling pathway regulate the pathological angiogenesis of ischaemic retinopathy

Porphyrins are produced at scale through metabolic engineering and optimization of CPIII purification.

Small circular RNAs encoding one or more antigens and enclosed in subcutaneously injected lipid nanoparticles can elicit potent and durable antitumour T cell responses for robust tumour immunotherapy, particularly in combination with immune checkpoint inhibition, as shown in multiple mouse models of tumours.

Bats are a likely reservoir of zoonotic coronaviruses (CoVs). Here, analyzing bat CoV sequences in China, the authors find that alpha-CoVs have switched hosts more frequently than betaCoVs, identify a bat family and genus that are highly involved in host-switching, and define hotspots of CoV evolutionary diversity.

1,2-diaminations of double bonds represent a fundamental transformation in organic synthesis, the progress of which has largely been limited to symmetrical delivery of equivalent amine species. Here, the authors report a protocol using azocarboxamides to differentiate carbons of some double bonds, resulting in unsymmetrical diaminations, proceeding under organocatalytic conditions.

Surface charge patchiness has a great impact on the aggregation and solution stability of colloidal particles and globular proteins. Here, the authors report the solution behaviours of computationally designed peptide coiled-coil ‘bundlemer’ nanoparticles with controlled surface charge patchiness where only a single type of surface charge is allowed.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

This study reports the genomics- and metabolomics-guided discovery of aminovinyl-(methyl-)cysteine-containing peptides (ACyP). One of these peptides, massatide A, demonstrates excellent activity against drug-resistant gram-positive pathogens.

OpenFold is a trainable open-source implementation of AlphaFold2. It is fast and memory efficient, and the code and training data are available under a permissive license.

This study reveals 246 behaviour-related and 200 physiological factors associated with genetic predisposition to suicide attempts. Mendelian randomization further indicates causal links for 58 factors.

Flexible laminated polymer nanocomposites with the polymer layer confined are found to exhibit enhanced thermal stability and improved high-temperature energy storage capabilities.

Limited charge separation is a major challenge in creating efficient semiconductor photocatalysis. This work introduces a superlattice interface and S-scheme heterojunction for ultrafast charge separation and transfer in photocatalytic H₂ evolution.

The bacterial adhesin, RadD, enhances the ability of Fusobacterium nucleatum to interact with colorectal cancer cells and promote tumour development in mice.

Inhibition of immunocyte infiltration and activation has been suggested to ameliorate hepatic inflammation and fibrosis in nonalcoholic steatohepatitis. Here, the authors show PirB/LILRB2 regulates the migration of macrophages during NASH by binding with ANGPTL8, which is involved in the regulation of NASH development.

Using a large sample from the UK Biobank, the authors investigate the effects of dietary patterns on multiple aspects of brain health and mental health.

This genome-wide association study on persistent hepatitis B virus (HBV) infection among Chinese confirms previously associated genetic loci while discovering a novel protective locus at 8p21.3. The study also demonstrates the nearby gene INST10 suppresses HBV replication in vitro.

A magnetic galactic halo featuring coherent ridges several kiloparsecs above and below the Galactic Disk has been detected in multi-wavelength observations. The halo is probably a consequence of outflows driven by active star-forming regions in the disk.

INSIHGT is an affordable, non-destructive and accessible 3D spatial biology method that maps diverse biomolecules deep within tissues, such as proteins and RNA, thus advancing the understanding of complex biological systems on a multi-omics level.

Polygenic Risk Scores (PRS) show promise for facilitating cancer risk stratification. Here, the authors performed a large genome-wide association study and develop a PRS for nasopharyngeal carcinoma, which could improve risk stratification and personalized screening.

Using data-driven disease-progression modelling, Jiang, Wang, Zhou et al. characterized and replicated two distinct ‘trajectories’ of brain atrophy in patients with schizophrenia.

Using genetically engineered models, Genovese and colleagues study patterns of convergent evolution in renal cancer, and pinpoint dysregulation of interferon signaling as a means of adaptation to chromosomal instability in metastatic progression.

Wing touching induces a defensive response in D. melanogaster. Here, the authors show that female flies change the defensive response during courtship and after mating. This switch is mediated by functional reconfiguration of a neural circuit in the ventral nerve cord.