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Su et al. report that the super-enhancer K5aSE orchestrates Klf5andadditional targets via 3D chromatin interactions in ES cells, with CTCF-mediated chromatin domains maintaining this regulatory network essential for ES cell identity.

Magnetic edge states of carbon quantum dots enable ultrafast electron relaxation and hot-carrier mobility, offering a high-relaxivity MRI-guided NIR-II photo-thermoelectric therapy.

At single-cell resolution, Tarkhov et al. delineate stochastic and co-regulated components of epigenetic aging, revealing a simultaneous loss of regulation at the epigenetic and transcriptional levels in aging.

Mechanical forces play a critical role in regulating cancer cell behavior. Here, Li et al. report a 3D hydrogel platform embedded with near-infrared responsive macromolecular actuators for precise mechanical stimulation of specific integrin subtypes in ovarian cancer cells to investigate how different force parameters affect cell migration and invasion.

Currently, there is limited knowledge about the spatial heterogeneity of glioma-driving molecular events. Here, the authors employ a multiomics approach to characterize the spatial transcriptomic heterogeneity of various types of gliomas and identify spatially distinct tumor subclones with genomic plasticity driven by mutations on extrachromosomal DNA.

Glioma stem-like cells (GSCs) contribute to therapeutic resistance via enhanced capability of DNA damage repair. Here the authors identify that the upregulated transcription factor AATF in GSCs modulates the stability and release of XRCC4 protein to promote DNA repair and resistance to radiotherapy.

Crop diversity enhancement can be a more efficient strategy for pesticide reduction if various components of functional diversity are considered, according to an analysis of 1285 cropping systems in French arable farms.

In this Tools of the Trade article, Bohan Zhang (Gladyshev lab) discusses how the use of extended heterochronic parabiosis in mice (surgical connection between circulatory systems for an extended period), followed by detachment, can shed light on potential mechanisms that reverse mammalian ageing.

This research highlights the role of a KNOX1 transcription factor in stalling receptacle growth in cucumber, leading to bisexual flowers with superior ovaries like those in tomatoes. These insights enhance our understanding of ovary formation and sex in cucurbits.

The challenges in reliably reproducing the quantum anomalous Hall effect have emerged as a major bottleneck for MnBi₂Te₄. Here, the authors develop a fabrication method to address this, paving the way for the fabrication of high-quality dissipationless topological transport devices.

A new device based on 7-septuple-layer MnBi₂Te₄ covered with an AlO_x capping layer enables the investigation of antiferromagnetic quantum anomalous Hall effect over wide parameter spaces.

Existing 3D Spatial Transcriptomics reconstruction approaches often overlook spatial information or experiment-induced distortions. Here, authors propose ST-GEARS to bridge the gap between in vivo cell locations and in vitro analysis, accurately recovering spatial profiles.

Defect engineering holds great potential for adjusting piezoelectric performance. Here, the authors decipher the diverse impacts of transition metal impurities on modifying piezoelectric properties from the perspective of intrinsic polarization behaviors in KTa_1−xNb_xO₃ crystals.

New protein synthesis is known to be indispensable for the consolidation of long-term memory. Here, the authors report that an olfactory memory can be successfully recalled after 14 days without protein synthesis when the training context is also provided in addition to the conditioned odor.

Chromosome-level genome assemblies of three Allium crops (onion, garlic and Welsh onion) and spatial RNA sequencing provide insights into Allium trait evolution and gene expression patterns during onion bulb formation.

MnBi2Te4 is an antiferromagnetic topological insulator. This combination of magnetic ordering and topological properties has resulted in intense interest, however, like many van der Waals materials, experimental results are hampered by fabrication difficulties. Here, Li, Wang, Lian et al. show that the fabrication process itself can result in mismatched thickness dependence of magneto-transport measurements. ‘

Heterochronic parabiosis ameliorates age-related diseases in mice, but how it affects epigenetic aging and long-term health was not known. Here, the authors show that in mice exposure to young circulation leads to reduced epigenetic aging, an effect that persists for several months after removing the youthful circulation.

Manipulating collective phenomena in solid-state platforms with optical means is an ongoing topic of interest in condensed matter physics. Here, the authors demonstrate all-optical room-temperature manipulation of electronic states in the charge-density-wave material EuTe₄.

Here the authors conduct a multi-ancestry meta-analysis of telomere length, used diverse approaches to identify genes underlying association signals, and experimentally validated POP5 and KBTBD6 as regulators of telomere length in human cells.

Authors find that freestanding single crystalline antiferroelectric PbZrO₃ membranes exhibit remarkable flexibility that can endure a maximum bending strain of 3.5%, with the assistance of mechanical-induced antiferroelectric-ferroelectric phase transition.

Mechanistic studies demonstrate that circFNDC3B binds TFII-I, suppressing CXCL10 and CXCL11 transcriptional activation, consequently impairing CD8⁺ T cell infiltration and anti-tumor immunity in NSCLC.

Single-cell DNA methylomic studies offer high resolution to differentiate cell subsets based on their epigenomic features. Here, the authors demonstrate Drop-BS, a droplet-based single-cell bisulfite sequencing library preparation method, for DNA methylome profiling.

The integration of epitaxial complex oxides on semiconductor and flexible substrates is required but challenging. Here, the authors report the highly heterogeneous epitaxy of transferrable BaTiO_3-δ membrane with enhanced flexoelectricity on Ge (011).

The exceptionally long-lived naked mole-rat is characterized by the lack of increased mortality with aging. Here the authors perform epigenetic studies to show that naked mole-rats epigenetically age despite their non-increasing mortality rate.

The elastic energy built up during peptide self-assembly is exploited in the realization of a microactuator. The energy stored is released on millisecond timescales via a buckling instability controlled with droplet microfluidics.

Soft robots are challenging to model and program. Non-specialists face non-negligible obstacles when working with soft robots to perform tasks. Here, the authors propose a method to interactively teach soft robots complex motions through flexible touchless and tactile multimodal sensors.

When many people are speaking, e.g. at a party, we can selectively attend to just one speaker. Here, using ‘hyperscanning’, the authors show that interpersonal neural synchronization is selectively increased between a listener and the attended speaker, compared to between the listener and an unattended speaker.

Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CAmutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation.

A way of integrating photonics with silicon nanoelectronics is described, using polycrystalline silicon on glass islands alongside transistors on bulk silicon complementary metal–oxide–semiconductor chips.

This protocol provides instructions for the fabrication, assembly and operation of a microfluidic device used for chromatin immunoprecipitation followed by sequencing to profile histone modifications in low-input samples.

In this Review, the authors discuss the concept of molecular damage in aging, from theoretical models to experimental approaches and how to test interventions targeting aging that reduce its burden.