Nature Search

ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution

Embryonal tumour with multilayered rosettes (ETMR) is a rare and aggressive paediatric brain tumour. Here, the authors analyse intratumour heterogeneity and the tumour microenvironment in ETMR using single-cell and spatial transcriptomics, in vitro cultures, and a 3D forebrain organoid model, finding important aspects – such as the communication with pericytes – for ETMR development and response to therapy.

Flavia W. de Faria
Nicole C. Riedel
Kornelius Kerl
ResearchOpen Access25 Jun 2025
Nature Communications

Volume: 16, P: 1-19
Microvascular immunity is organ-specific and remodeled after kidney injury in mice

During tissue injury blood cells in the microvasculature and tissue resident cells have differing phenotypes. Here the authors use single cell transcriptomics in mice models to assess the differences in phenotype of immune cells in multiple organs and the tissue resident cells before, after and during acute kidney infection.

Rebecca Rixen
Paula Schütz
Konrad Buscher
ResearchOpen Access09 May 2025
Nature Communications

Volume: 16, P: 1-12
Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis

This study identifies a unique multiple sclerosis lesion, the broad rim lesion, which is associated with rapid disease progression and marked by a distinct inflammatory profile involving innate inflammation, cellular stress, unfolded protein response and apoptosis.

Luisa Klotz
Joost Smolders
Tanja Kuhlmann
ResearchOpen Access29 Apr 2025
Nature Medicine

Volume: 31, P: 2016-2026
The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang
Reviews02 Jul 2025
Nature

Volume: 643, P: 47-59
Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas

Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous and aggressive type of T-cell lymphoma. Here, the authors perform single-cell analyses of human and murine PTCL-NOS tumors, and identify a subtype defined by the loss of SMARCB1 that could be targeted with HDAC-inhibitor combination therapies.

Anja Fischer
Thomas K. Albert
Kornelius Kerl
ResearchOpen Access03 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures

Paediatric high-grade gliomas with MYCN amplification (HGG-MYCN) are rare and highly aggressive. Here, the authors generate a mouse model for HGG-MYCN that can recapitulate the histological and molecular profiles of the human tumours, and perform high-throughput drug screening to identify potential treatment options.

Melanie Schoof
Shweta Godbole
Ulrich Schüller
ResearchOpen Access24 Nov 2023
Nature Communications

Volume: 14, P: 1-13
Structure of the yeast ceramide synthase

Using cryo-electron microscopy, Schäfer et al. solved the structure of the yeast ceramide synthase complex, consisting of Lip1, Lag1 and Lac1 subunits. They found that fumonisin B1 binds competitively at a key site, suggesting a mechanism for ceramide synthesis.

Jan-Hannes Schäfer
Lena Clausmeyer
Florian Fröhlich
Research11 Nov 2024
Nature Structural & Molecular Biology

Volume: 32, P: 441-449
Author Correction: The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma

Philip Smith
Thomas Bradley
Iain A. McNeish
Amendments and CorrectionsOpen Access26 Sept 2023
Nature Communications

Volume: 14, P: 1
A CCG expansion in ABCD3 causes oculopharyngodistal myopathy in individuals of European ancestry

A significant proportion of individuals with inherited neuromuscular disease do not receive a genetic diagnosis. Here, the authors establish CCG expansions in the 5’ untranslated region of ABCD3 as a cause of oculopharyngodistal myopathy (OPDM) in individuals of European ancestry and identify increased expression of expansion-containing ABCD3 transcripts as a possible disease mechanism underlying muscle degeneration.

Andrea Cortese
Sarah J. Beecroft
Gianina Ravenscroft
ResearchOpen Access27 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Structure of the ceramide-bound SPOTS complex

Sphingolipids are structural membrane components produced by the serine palmitoyl transferase (SPT). Here, the authors solved the cryo EM structure of the ceramide bound yeast SPOTS complex. This explains how ceramide regulates the activity of the yeast SPT complex.

Jan-Hannes Schäfer
Carolin Körner
Florian Fröhlich
ResearchOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-12
Factors associated with reduction in quality of life after SARS-CoV-2 infection

Christian Neumann
Tim J. Hartung
Walter Maetzler
ResearchOpen Access26 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
Prognostic impact of clonal representation of myelodysplasia-related gene mutations in acute myeloid leukemia

Rabea Mecklenbrauck
Nora Borchert
Michael Heuser
ResearchOpen Access28 Apr 2025
Leukemia

Volume: 39, P: 1773-1777
Author Correction: A CCG expansion in ABCD3 causes oculopharyngodistal myopathy in individuals of European ancestry

Andrea Cortese
Sarah J. Beecroft
Gianina Ravenscroft
Amendments and CorrectionsOpen Access17 Oct 2024
Nature Communications

Volume: 15, P: 1
Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Empirically based models of disease progression in familial frontotemporal dementia reveal the relative ordering of clinical, neuroimaging, and fluid biomarker changes and facilitate novel clinical trial designs

Adam M. Staffaroni
Melanie Quintana
Sónia Afonso
Research22 Sept 2022
Nature Medicine

Volume: 28, P: 2194-2206
The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma

‘Treatment resistance is common in ovarian high grade serous carcinoma, often leading to relapse. Here, the authors leverage shallow whole genome and panel sequencing of 276 patients with available diagnostic and relapse samples and show high concordance of copy number and mutation status.

Philip Smith
Thomas Bradley
Iain A. McNeish
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-15
MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas

The MAPK pathway is a key driver of pediatric low-grade gliomas (pLGG); however, response to MAPK inhibitors (MAPKi) in pLGG patients is not consistent. Here, the authors develop MAPKi sensitivity scores (MSS) to predict response to MAPKi and apply them to bulk and single-cell sequencing datasets from pLGG patients and preclinical models.

Romain Sigaud
Thomas K. Albert
Till Milde
ResearchOpen Access27 Jul 2023
Nature Communications

Volume: 14, P: 1-21
High-sensitivity dual-comb and cross-comb spectroscopy across the infrared using a widely tunable and free-running optical parametric oscillator

The authors demonstrate a widely tunable dual-comb optical parametric oscillator in the mid-infrared, and combine it with an intra-cavity up-conversion detection scheme to obtain high-sensitivity and high-resolution spectroscopy measurements.

Carolin P. Bauer
Zofia A. Bejm
Christopher R. Phillips
ResearchOpen Access22 Aug 2024
Nature Communications

Volume: 15, P: 1-13
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID

Infection or chronic inflammation is a risk factor for childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors show that the DNA editing enzyme AID is expressed in infected B cells but using genetic mouse models show that it does not contribute to leukemia pathogenesis.

Guillermo Rodríguez-Hernández
Friederike V. Opitz
Arndt Borkhardt
ResearchOpen Access05 Dec 2019
Nature Communications

Volume: 10, P: 1-10
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

A multiancestry genome-wide association study of chronic alanine aminotransferase elevation identifies candidate risk loci for nonalcoholic fatty liver disease, with replication in external cohorts defined by histology or imaging.

Marijana Vujkovic
Shweta Ramdas
Kyong-Mi Chang
Research02 Jun 2022
Nature Genetics

Volume: 54, P: 761-771
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling

Patients with primary sclerosing cholangitis (PSC), a chronic cholestatic liver disease, display changes in the gut microbiota and in bile acid composition. Schneider, Candels and colleagues identify a role for microbiota-dependent regulation of bile acid synthesis through farnesoid X receptor signalling, which is relevant for PSC disease progression.

Kai Markus Schneider
Lena Susanna Candels
Christian Trautwein
Research22 Sept 2021
Nature Metabolism

Volume: 3, P: 1228-1241
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

Adult neural stem and progenitor cells (NSPCs) show high levels of fatty acid synthase (Fasn)-dependent de novo lipogenesis, a process that is controlled by Spot14 to regulate the rate of proliferation; this indicates a functional coupling between the regulation of lipid metabolism and adult NSPC proliferation.

Marlen Knobloch
Simon M. G. Braun
Sebastian Jessberger
Research02 Dec 2012
Nature

Volume: 493, P: 226-230
Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils

Neutrophils rapidly respond to bacterial and fungal infections but can cause substantial collateral tissue damage if not restrained. Rosenbauer and colleagues show that the transcription factor PU.1 serves a cell-intrinsic role to prevent over-exuberant neutrophil responses to fungal infection.

Josephine Fischer
Carolin Walter
Frank Rosenbauer
Research25 Mar 2019
Nature Immunology

Volume: 20, P: 546-558
An elementary quantum network of single atoms in optical cavities

Single atoms in optical cavities in two separate laboratories are the nodes of an elementary quantum network, in which quantum information is distributed via the controlled emission and absorption of single photons.

Stephan Ritter
Christian Nölleke
Gerhard Rempe
Research11 Apr 2012
Nature

Volume: 484, P: 195-200
Swarm Learning for decentralized and confidential clinical machine learning

Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.

Stefanie Warnat-Herresthal
Hartmut Schultze
Joachim L. Schultze
ResearchOpen Access26 May 2021
Nature

Volume: 594, P: 265-270
The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice

Melanie Schoof
Gefion Dorothea Epplen
Ulrich Schüller
ResearchOpen Access05 Jul 2023
Oncogenesis

Volume: 12, P: 1-11
Synergistic Strategy for Multicolor Two-photon Microscopy: Application to the Analysis of Germinal Center Reactions In Vivo

Asylkhan Rakhymzhan
Ruth Leben
Raluca A. Niesner
ResearchOpen Access02 Aug 2017
Scientific Reports

Volume: 7, P: 1-16
Comprehensive germline-genomic and clinical profiling in 160 unselected children and adolescents with cancer

Rabea Wagener
Julia Taeubner
Triantafyllia Brozou
ResearchOpen Access12 Apr 2021
European Journal of Human Genetics

Volume: 29, P: 1301-1311
Psycho-social factors associated with mental resilience in the Corona lockdown

Ilya M. Veer
Antje Riepenhausen
Raffael Kalisch
ResearchOpen Access21 Jan 2021
Translational Psychiatry

Volume: 11, P: 1-11
Reduced cell size, chromosomal aberration and altered proliferation rates are characteristics and confounding factors in the STHdh cell model of Huntington disease

Elisabeth Singer
Carolin Walter
Huu P. Nguyen
ResearchOpen Access04 Dec 2017
Scientific Reports

Volume: 7, P: 1-13
Influence of Familial Risk for Depression on Cortico-Limbic Connectivity During Implicit Emotional Processing

Carolin Wackerhagen
Torsten Wüstenberg
Nina Romanczuk-Seiferth
Research15 Mar 2017
Neuropsychopharmacology

Volume: 42, P: 1729-1738
Clinical correlates of CT imaging-derived phenotypes among lean and overweight patients with hepatic steatosis

Isabel Song
Elizabeth W. Thompson
Hersh Sagreiya
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-14
Phenome of coeliac disease vs. inflammatory bowel disease

Moritz Kleinjans
Carolin V. Schneider
Pavel Strnad
ResearchOpen Access26 Aug 2022
Scientific Reports

Volume: 12, P: 1-10
Effects of Antidepressants on the Brain/Plasma Distribution of Corticosterone

Claudia-Carolin Weber
Gunter P Eckert
Walter E Müller
Research12 Apr 2006
Neuropsychopharmacology

Volume: 31, P: 2443-2448
Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus

Claudia Dafinger
Markus M. Rinschen
Max C. Liebau
ResearchOpen Access28 Jun 2018
Experimental & Molecular Medicine

Volume: 50, P: 1-17
Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients

Carolin E. M. Koll
Sina M. Hopff
O. Witzke
ResearchOpen Access21 Dec 2022
Scientific Data

Volume: 9, P: 1-15
The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults

Hengyi Cao
Anais Harneit
Heike Tost
Research07 Jun 2017
Neuropsychopharmacology

Volume: 43, P: 406-414
The prevalence of pediatric metabolic syndrome—a critical look on the discrepancies between definitions and its clinical importance

Carolin Reisinger
Benedicta N. Nkeh-Chungag
Nandu Goswami
ReviewsOpen Access18 Nov 2020
International Journal of Obesity

Volume: 45, P: 12-24

Search

ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution

Microvascular immunity is organ-specific and remodeled after kidney injury in mice

Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis

The Somatic Mosaicism across Human Tissues Network

Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas

Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures

Structure of the yeast ceramide synthase

Author Correction: The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma

A CCG expansion in ABCD3 causes oculopharyngodistal myopathy in individuals of European ancestry

Structure of the ceramide-bound SPOTS complex

Factors associated with reduction in quality of life after SARS-CoV-2 infection

Prognostic impact of clonal representation of myelodysplasia-related gene mutations in acute myeloid leukemia

Author Correction: A CCG expansion in ABCD3 causes oculopharyngodistal myopathy in individuals of European ancestry

Temporal order of clinical and biomarker changes in familial frontotemporal dementia

The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma

MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas

High-sensitivity dual-comb and cross-comb spectroscopy across the infrared using a widely tunable and free-running optical parametric oscillator

Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils

An elementary quantum network of single atoms in optical cavities

Swarm Learning for decentralized and confidential clinical machine learning

The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice

Synergistic Strategy for Multicolor Two-photon Microscopy: Application to the Analysis of Germinal Center Reactions In Vivo

Comprehensive germline-genomic and clinical profiling in 160 unselected children and adolescents with cancer

Psycho-social factors associated with mental resilience in the Corona lockdown

Reduced cell size, chromosomal aberration and altered proliferation rates are characteristics and confounding factors in the STHdh cell model of Huntington disease

Influence of Familial Risk for Depression on Cortico-Limbic Connectivity During Implicit Emotional Processing

Clinical correlates of CT imaging-derived phenotypes among lean and overweight patients with hepatic steatosis

Phenome of coeliac disease vs. inflammatory bowel disease

Effects of Antidepressants on the Brain/Plasma Distribution of Corticosterone

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus

Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients

The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults

The prevalence of pediatric metabolic syndrome—a critical look on the discrepancies between definitions and its clinical importance

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