Nature Search

Quadrivalent human papillo-mavirus recombinant vaccine

In June 2006, a quadrivalent human papillomavirus (types 6, 11, 16 and 18) recombinant vaccine (Gardasil; Merck) was approved by the US FDA for the prevention of several diseases, including cervical cancer, that are caused by these types of human papillomavirus.

Christopher Crum
Carole Jones
Peter Kirkpatrick
Comments & Opinion01 Aug 2006
Nature Reviews Drug Discovery

Volume: 5, P: 629-630
Rethinking ovarian cancer: recommendations for improving outcomes

This Opinion article outlines nine major recommendations for improving our understanding of ovarian cancer and the outcomes of women with this group of diseases.

Sebastian Vaughan
Jermaine I. Coward
Frances R. Balkwill
Reviews23 Sept 2011
Nature Reviews Cancer

Volume: 11, P: 719-725
p63 protects the female germ line during meiotic arrest

Whereas the tumour suppressor gene p53 plays a key role in monitoring and maintaining genomic integrity in somatic cells, it is now shown that in oocytes, a p53 family member, p63 (but not p53 itself), is needed to protect against DNA damage. The specific isoform of p63 that is involved also seems to be the founding member of the p53 family.

Eun-Kyung Suh
Annie Yang
Frank McKeon
Research01 Nov 2006
Nature

Volume: 444, P: 624-628
Squamocolumnar junction ablation—tying up loose ends?

Despite the commercialization of HPV vaccines, cervical cancer remains a major cause of death, especially in developing countries. Recent data implicate a discrete population of cells within the cervical squamocolumnar junction in the pathogenesis of cervical precancerous lesions, indicating that ablation of these cells might reduce the rate of cervical cancer in high-risk populations.

Michael Herfs
Christopher P. Crum
News & Views02 Jun 2015
Nature Reviews Clinical Oncology

Volume: 12, P: 378-380
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

Annie Yang
Ronen Schweitzer
Frank McKeon
Research22 Apr 1999
Nature

Volume: 398, P: 714-718
Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours

Despite methodological improvements, it remains extremely difficult to routinely establish cell lines from human primary tumours. Here, the authors develop a culture medium that allows efficient cell line establishment and use this to generate 25 ovarian cancer cell lines.

Tan A. Ince
Aurea D. Sousa
Gordon B. Mills
ResearchOpen Access17 Jun 2015
Nature Communications

Volume: 6, P: 1-14
Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion

Barrett’s oesophagus is a precancerous intestinal metaplasia that can progress to oesophageal adenocarcinoma. In this study, the authors isolate and characterize human Barrett’s stem cells and identify a specific genomic pedigree that supports the potential role of these cells as precursors of oesophageal adenocarcinoma.

Yusuke Yamamoto
Xia Wang
Wa Xian
ResearchOpen Access19 Jan 2016
Nature Communications

Volume: 7, P: 1-10
Cloning and variation of ground state intestinal stem cells

Novel technology to rapidly clone patient-specific, ‘ground state’ stem cells of columnar epithelia reveals their proliferative potential, remarkably precise and origin-dependent lineage commitment as well as genomic stability, despite extensive culturing, thereby skirting limitations associated with pluripotent stem cells.

Xia Wang
Yusuke Yamamoto
Wa Xian
Research03 Jun 2015
Nature

Volume: 522, P: 173-178
Intercepting early pelvic serous carcinoma by routine pathological examination of the fimbria

Dana R Semmel
Ann K Folkins
Christopher P Crum
Research01 May 2009
Modern Pathology

Volume: 22, P: 985-988
Do-it-yourself (DIY) pathology

Tan A Ince
Jerrold M Ward
Robert D Cardiff
Correspondence01 Sept 2008
Nature Biotechnology

Volume: 26, P: 978-979
p63⁺Krt5⁺ distal airway stem cells are essential for lung regeneration

Many patients experiencing sudden loss of lung tissue somehow undergo full recovery; here this recovery is traced to a discrete population of lung stem cells that are not only essential for lung regeneration but can be cloned and then transplanted to other mice to contribute new lung tissue.

Wei Zuo
Ting Zhang
Frank McKeon
Research12 Nov 2014
Nature

Volume: 517, P: 616-620
Landscape of genomic alterations in cervical carcinomas

Whole-exome sequencing and analysis of 115 cervical carcinoma–normal paired samples, in addition to transcriptome and whole-genome sequencing for a subset of these tumours, reveal novel genes mutated at significant levels within this cohort and provide evidence that HPV integration is a common mechanism for target gene overexpression; results also compare mutational landscapes between squamous cell carcinomas and adenocarcinomas.

Akinyemi I. Ojesina
Lee Lichtenstein
Matthew Meyerson
Research25 Dec 2013
Nature

Volume: 506, P: 371-375
The impact of tissue block sampling on the detection of p53 signatures in fallopian tubes from women with BRCA 1 or 2 mutations (BRCA+) and controls

Karishma K Mehra
Martin C Chang
Aasia Saleemuddin
Research24 Sept 2010
Modern Pathology

Volume: 24, P: 152-156
p16ink4 and cytokeratin 7 immunostaining in predicting HSIL outcome for low-grade squamous intraepithelial lesions: a case series, literature review and commentary

Eric C Huang
Mary M Tomic
Christopher P Crum
Research12 Aug 2016
Modern Pathology

Volume: 29, P: 1501-1510
High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression

Michael H Roh
Yosuf Yassin
Christopher P Crum
Research18 Jun 2010
Modern Pathology

Volume: 23, P: 1316-1324
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Inglese et al. develop a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted magnetic resonance imaging scans. Their model reliably discriminates people with Alzheimer’s disease-related pathologies from those without.

Marianna Inglese
Neva Patel
Eric O. Aboagye
ResearchOpen Access20 Jun 2022
Communications Medicine

Volume: 2, P: 1-16
Phosphorylated S6 as an immunohistochemical biomarker of vulvar intraepithelial neoplasia

Alvaro P Pinto
Martin Degen
James G Rheinwald
Research14 Jun 2013
Modern Pathology

Volume: 26, P: 1498-1507
Evidence for a latent precursor (p53 signature) that may precede serous endometrial intraepithelial carcinoma

Elke A Jarboe
Ellen S Pizer
Christopher P Crum
Research16 Jan 2009
Modern Pathology

Volume: 22, P: 345-350
Biomarker (ProEx^TM C, p16^INK4A, and MiB-1) distinction of high-grade squamous intraepithelial lesion from its mimics

Alvaro P Pinto
Nicolas F Schlecht
Edmund S Cibas
Research13 Jun 2008
Modern Pathology

Volume: 21, P: 1067-1074
Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma

Alvaro P Pinto
Alexander Miron
Christopher P Crum
Research08 Jan 2010
Modern Pathology

Volume: 23, P: 404-412
PAX2-null secretory cell outgrowths in the oviduct and their relationship to pelvic serous cancer

Charles M Quick
Gang Ning
Christopher P Crum
Research11 Nov 2011
Modern Pathology

Volume: 25, P: 449-455
Digital quantification of precursor frequency in the fallopian tube and its significance

Jonathan G Bijron
Gang Ning
Christopher P Crum
Research06 Jul 2012
Modern Pathology

Volume: 25, P: 1654-1661
Cloning of ground-state intestinal stem cells from endoscopic biopsy samples

Libraries of highly immature, ground-state human intestinal stem cells are established from endoscopic biopsy samples. Single cell–derived clones can be rapidly expanded for molecular genetics, 3D differentiation, disease modeling and drug discovery.

Marcin Duleba
Yusuke Yamamoto
Wa Xian
Protocols01 Apr 2020
Nature Protocols

Volume: 15, P: 1612-1627
Squamous morules are functionally inert elements of premalignant endometrial neoplasia

Ming-Chieh Lin
Lesley Lomo
George L Mutter
Research19 Sept 2008
Modern Pathology

Volume: 22, P: 167-174
Histological ‘progression’ from low (LSIL) to high (HSIL) squamous intraepithelial lesion is an uncommon event and an indication for quality assurance review

Eleanor Y Chen
Ann Tran
Michelle S Hirsch
Research14 May 2010
Modern Pathology

Volume: 23, P: 1045-1051
Serous tubal intraepithelial neoplasia: the concept and its application

Emily E K Meserve
Jan Brouwer
Christopher P Crum
Research20 Jan 2017
Modern Pathology

Volume: 30, P: 710-721
Molecular characterization of diffuse malignant peritoneal mesothelioma

Yin P. Hung
Fei Dong
Lucian R. Chirieac
Research05 Jun 2020
Modern Pathology

Volume: 33, P: 2269-2279
A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine

Michael Herfs
Patrick Roncarati
Philippe Delvenne
ResearchOpen Access27 Apr 2018
British Journal of Cancer

Volume: 118, P: 1302-1312
Histologic and immunohistochemical decision-making in endometrial adenocarcinoma

Lesley Lomo
Marisa R Nucci
George L Mutter
Research23 May 2008
Modern Pathology

Volume: 21, P: 937-942
Microanatomy of the cervical and anorectal squamocolumnar junctions: a proposed model for anatomical differences in HPV-related cancer risk

Eric J Yang
Matthew C Quick
Michael Herfs
Research15 May 2015
Modern Pathology

Volume: 28, P: 994-1000
Clinical outcome in diagnostically ambiguous foci of ‘gland crowding’ in the endometrium

Eric C Huang
George L Mutter
Marisa R Nucci
Research30 Jul 2010
Modern Pathology

Volume: 23, P: 1486-1491
Contemporary Theories of Cervical Carcinogenesis: The Virus, the Host, and the Stem Cell

Christopher P Crum
Research01 Mar 2000
Modern Pathology

Volume: 13, P: 243-251
MicroRNA-200 family governs ovarian inclusion cyst formation and mode of ovarian cancer spread

Pui-Wah Choi
Wai Wing So
Shu-Wing Ng
Research25 Mar 2020
Oncogene

Volume: 39, P: 4045-4060
Genome of the tropical plant Marchantia inflexa: implications for sex chromosome evolution and dehydration tolerance

Rose A. Marks
Jeramiah J. Smith
D. Nicholas McLetchie
ResearchOpen Access19 Jun 2019
Scientific Reports

Volume: 9, P: 1-13
Mural nodules in mucinous ovarian tumors represent a morphologic spectrum of clonal neoplasms: a morphologic, immunohistochemical, and molecular analysis of 13 cases

David B. Chapel
Elizabeth K. Lee
Marisa R. Nucci
Research05 Aug 2020
Modern Pathology

Volume: 34, P: 613-626
SMARCA4-deficient undifferentiated uterine sarcoma (malignant rhabdoid tumor of the uterus): a clinicopathologic entity distinct from undifferentiated carcinoma

David L. Kolin
Fei Dong
Brooke E. Howitt
Research26 Apr 2018
Modern Pathology

Volume: 31, P: 1442-1456
Clinical features and outcomes in primary nervous system histiocytic neoplasms

Nabeela Nathoo
Joon H. Uhm
Lucinda M. Gruber
CorrespondenceOpen Access20 Jun 2024
Blood Cancer Journal

Volume: 14, P: 1-6
Morphologic correlates of molecular alterations in extrauterine Müllerian carcinomas

Lauren L Ritterhouse
Jonathan A Nowak
Brooke E Howitt
Research06 May 2016
Modern Pathology

Volume: 29, P: 893-903
Response to Gilks et al

Michael H Roh
Marisa R Nucci
Christopher P Crum
Correspondence02 Sept 2011
Modern Pathology

Volume: 24, P: 1282-1283
Differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in PIK3CA

Jaclyn C Watkins
Brooke E Howitt
Christopher P Crum
Research11 Nov 2016
Modern Pathology

Volume: 30, P: 448-458

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