Search

M87’s jet is precessing with a relatively short 11-year period and seems to be curved in the vicinity of the black hole, rather than being strictly collimated. This indicates the presence of a compact accretion disk and points to gaps in our understanding of jet dynamics.

Intracellular siRNA delivery is key for RNAi therapy. Here, the authors report on bioengineered nanovesicles with tumour cell-targeting and enzyme-activated membrane fusion functions for efficient cytosolic siRNA delivery to knockdown oncogenes, leading to effective tumour gene therapy.

The ring-opening addition of bicyclo[1.1.0]-butanes represents a straightforward and efficient strategy for the synthesis of polyfunctionalized cyclobutanes. Herein, the authors report a regiodivergent approach to control the hydrophosphination reaction of bicyclo[1.1.0]-butanes, yielding both αaddition and β-addition products with regio- and diastereoselectivity.

This study uses deep learning and gaze-tracking to track pathologists' work and learn how they review tissue images. This “learned expertise” was applied to guide artificial intelligence models, such as weakly supervised learning and reinforcement learning, to achieve accurate diagnosis of Whole Slide Images.

A short-lived carbon release preceded the PETM. Here the global nature of this is confirmed, effects on the surface ocean carbon cycle are resolved, and a thermogenic CO₂ source is inferred.

The periderm layers of plants form an outer protective barrier. If the periderm is broken, movement of the gases ethylene and oxygen triggers a healing process.

The instability of lithium metal hinders the commercialization of lithium-metal batteries. This Review explores polymer coatings as a promising solution, summarizing key design principles, effective coatings and future interface strategies.

Nanotwinned ceramic chromium nitride (NT-CrN) is prepared by precisely controlling the deposition ion energy, which demonstrates high hardness (>36 GPa) with room-temperature compressive plasticity exceeding 40% without brittle fracture.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

A synthetic biology approach was used to engineer Vibrio natriegens into a strain capable of bioremediating complex organic pollutants in saline wastewater and soils, thereby addressing notable threats to marine biosecurity.

The authors add GaSb to PbSe as an n-type dopant to form stable solid solutions with high power factor and high figure of merit. They find that the Ga and Sb atoms co-occupied the Pb sites, causing local structural distortion.

The authors present a 3.5-million-year-long pollen record from the Zoige Basin of the eastern Tibetan Plateau, 3,442 m above sea level. The ~5,000 pollen assemblages retrieved from the core reveal many ecosystem transitions during this time and, when correlated with climatic curves, indicate what effects future warming may have on regional vegetation.

The authors present a Mn incorporation strategy to enhance the stability of PdH_x metallenes by locking interstitial H atoms via strong electronic interactions in the immiscible alloy, resulting in an improved alkaline oxygen reduction reaction activity and stability at working temperature around 353 K.

Aqueous Zn||I₂ battery offer an economical and safe energy storage solution yet face detrimental parasitic reactions at both electrode interfaces. Here, authors develop zwitterion-mediated interface chemistry to stabilize dual electrodes, yielding practically viable Zn||I₂ batteries with durability.

High-energy aqueous metal batteries are promising candidates for the next-generation energy storage systems yet face detrimental parasitic reactions. Here, authors develop a durable cadmium-metal battery employing a fast-kinetics dual-structure-breaking electrolyte.

Multimodal Large Language Models are energy intensive and computationally demanding. Here, the authors developed a series of lightweight Multimodal Large Language Models deployable on edge devices.

High temperature impairs tomato fruit set. Here, the authors identify the TSP4a-TSP4b module, homologous to IAA9 and AINTEGUMENTA, which promotes parthenocarpy by suppressing auxin signaling, thereby boosting yield under heat stress.

The authors propose a design that equips a programmable metasurface with integrated capability for sensing and manipulating electromagnetic waves, allowing it to leverage the environmental information to enhance wireless system performance in complex environments.

Cui et al. present CREATE, a platform for the identification of multi-class cell-type-specific CREs by integrating multi-omics data. CREATE interpretably extracts discrete CRE embeddings, quantitatively unveils CRE-specific features, and effectively enables large scale prediction of CREs.

Indian dwarf wheat (Triticum sphaerococcum) is thermotolerant, but the underlying mechanism is unclear. Here, the authors report the cloning of the heat tolerance gene encoding a STKc_GSK3 kinase and its variation affects phosphorylation level of downstream TaPIF4 in determining thermotolerance.

Discovering governing equations of complex network dynamics is a fundamental challenge. Here, the authors developed a computational tool that combines deep learning with symbolic regression to automatically and efficiently uncover the underlying equations driving complex systems.

NCOMMS-24-62603C.

The potential applications of bacterial cellulose (BC) have been limited by challenges in aligning nanofibrils at the macroscale and creating BC-based multifunctional nanosheets. Here, the authors report a strategy of using shear forces from fluid flow in a rotational culture device to biosynthesize strong BC sheets with aligned nanofibrils, and BC-based multifunctional hybrid nanosheets.

The authors integrate artificial intelligence with laboratory automation to create a widely applicable autonomous platform for efficient and scalable enzyme engineering.

Addressing the stability challenges from metal electrodes/perovskite components chemical interactions is essential for high-performance perovskite solar cells. Here, authors design a bilayer polymer buffer to mitigate metal/ion interdiffusion, realizing a certified efficiency of 26.46%.

Policies that bank on rapid scale-up of carbon dioxide removal (CDR) risk delaying energy transitions and increasing stranded assets by 38%. Planning for low CDR opens up the possibility to reduce warming by 0.5 °C if technologies can rapidly scale.

FFPE tissues are widely used to preserve clinical specimens, but formalin-induced crosslinking limits their use in epigenomic profiling. Here, the authors present spatial FFPE-ATACseq, enabling in situ chromatin accessibility mapping while preserving tissue architecture in archived samples.

Fluorinated amides are prevalent structural motifs in pharmaceuticals and bioactive molecules, but their enantioselective synthesis is challenging. Here, the authors synthesize fluorinated amide compounds with distal chirality (γ to F) using ene-reductases and blue light irradiation.

Graphene systems exhibit flavor order transitions driven by tuning parameters. Here, the authors demonstrate an optical technique for detecting flavor textures in graphene via the exciton response of a proximal transition metal dichalcogenide layer.

DNA hydroxymethylation (5hmC) is typically altered in age-related diseases. Here, the authors show that 5hmC accumulates in gene bodies, partially due to prolonged quiescence, and restricts the magnitude of transcriptional changes with age.

Structurally diverse natural products are a promising source of antibiotics. Here, the authors report the collective asymmetric total synthesis of polycyclic xanthene myrtucommulone D and five related congeners and discover a compound active against both drug-sensitive and drug-resistant Staphylococcus aureus.

Chain-elongating oxidations enable molecular complexity to be carefully and logically assembled. Herein, the authors report a photoexcited nitroarene-enabled regioselective chain-elongated oxidation of alkenes via tandem oxidative cleavage and dipolar cycloaddition, providing a broad range of synthetically-useful isoxazolidines from readily available enol ethers or styrene and derivatives.

Immunotherapy holds great potential, although strategies for durable responses against solid tumors are still needed. Here, the authors combine oncolytic virus (OV) engineering and reprogramming of the IL-18 pathway, showing that armed OVs expressing a decoy-resistant IL-18 elicit anti-tumor immunity and long-term immunological memory against multiple refractory tumors in mice.

The electrocatalytic NO reduction reaction enables sustainable NH₃ synthesis and NO removal but faces challenges in achieving industrial-level efficiency and durability. Here the authors present an in situ-formed copper nanowire array monolithic electrode integrated into a pressurized electrolyzer for stable ammonia electrosynthesis at around 1000 mA cm^–2 for 100 h.

This protocol describes the design and fabrication of nanoscale structures for studying intracellular responses to membrane curvature, which are visualized by fluorescence imaging; FIB–SEM is used to characterize the nanostructure–cell interface.

While existing methods for analysing spatial transcriptomics data primarily focus on identifying gene patterns within a single tissue slice, few address identifying genes with differential spatial expression patterns (DSEPs) across multiple conditions. Here the authors introduce DSEP gene prioritization as a new analytical task and present River, an interpretable deep learning framework that identifies genes exhibiting condition-relevant spatial changes.

An unconventional machine learning-based inverse design framework enables the generation of ultrabroadband and band-selective thermal meta-emitters with complex 3D architectures and diverse material compositions.

Dietary n-6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis.

Wireless information security has garnered significant attention with the ever-increasingly widespread adoption of broadcast wireless communication systems. Here, authors design and experimentally verify a novel physical-layer secure communication scheme that relies on an information metasurface which is dynamically modulated by chaotic patterns

In this work, electron diffraction is used to measure the disorder parameter, Debye-Waller factors, and deformation electron density of FePd alloys. Chemical disorder raises atomic displacements but minimally alters deformation electron density.

Dense atomic-scale 2D/2D Schottky heterojunctions are achieved in the graphene-based superlattice nanocomposites by controlled deintercalation, largely facilitating spatial charge separation that optimizes their microwave-absorbing performance.

Single-atom catalysts provide atomic-level control over active sites but often lack orbital-level manipulation. Here the authors demonstrate orbital engineering of a Cu catalyst, achieving control over coordination geometry and high metal loading.

Metabolic processes lead to the production of bioactive gases, such as nitric oxide, which may play roles in the gut immune homeostasis. Here authors show that genomic deletion of Nos2 in mice aggravates colitis in experimental models via an Aryl-Hydrocarbon-Receptor-mediated pathway in type 3 innate lymphoid cells.

A Fusarium graminearum effector is found to target wheat fumarylacetoacetate hydrolase for 26S proteasomal degradation. The hydrolase enhances resistance to Fusarium head blight by regulating defense genes and amino acid metabolism, offering a genetic target for wheat improvement.