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Showing 101–150 of 547 results

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Effectiveness of mRNA-1273 vaccination against SARS-CoV-2 omicron subvariants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5

In this study, the authors estimate the effectiveness of the mRNA-1273 (Moderna) vaccine for Omicron subvariants using data from the USA on ~31,000 cases and ~92,000 matched controls. They find that effectiveness against infection waned rapidly after third and fourth doses, but effectiveness against hospitalization remained high.

Hung Fu Tseng
Bradley K. Ackerson
Lei Qian
ResearchOpen Access12 Jan 2023
Nature Communications

Volume: 14, P: 1-10
Age- and sex-related variations in extracellular vesicle profiling for the assessment of cardiovascular risk: the EVaging index

Jacopo Burrello
Jessica Goi
Barile Lucio
ResearchOpen Access19 Dec 2024
npj Aging

Volume: 10, P: 1-13
Targeting SARS-CoV-2 receptor-binding ___domain to cells expressing CD40 improves protection to infection in convalescent macaques

In this study, Marlin et al. provide insights into the potential use of subunit vaccines that induce a high level of protection against SARS-CoV-2 in animal models.

Romain Marlin
Veronique Godot
Roger Le Grand
ResearchOpen Access01 Sept 2021
Nature Communications

Volume: 12, P: 1-9
Sex-specific effects of aging on humoral immune responses to repeated influenza vaccination in older adults

Janna R. Shapiro
Huifen Li
Sean X. Leng
ResearchOpen Access09 Dec 2021
npj Vaccines

Volume: 6, P: 1-11
Navigating and diagnosing cognitive frailty in research and clinical domains

Cognitive frailty (CF) is the complex and intertwined co-occurrence of physical frailty and cognitive decline. Untangling the interplay between these two domains and correctly diagnosing CF in the clinic is vital for early diagnosis and intervention.

Monica M. Nader
Caglar Cosarderelioglu
Peter M. Abadir
Reviews16 Oct 2023
Nature Aging

Volume: 3, P: 1325-1333
Risks and benefits of testosterone therapy in older men

In men with classic hypogonadism, testosterone therapy induces a number of beneficial effects. However, in older men with age-related decline in testosterone levels, the clinical benefits and long-term risks of testosterone therapy have not been adequately assessed in large, randomized clinical trials. This Review discusses potential benefits and risks of testosterone therapy in these individuals in the context of incomplete evidence on safety and efficacy.

Matthew Spitzer
Grace Huang
Shalender Bhasin
Reviews16 Apr 2013
Nature Reviews Endocrinology

Volume: 9, P: 414-424
Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia

Combining cytarabine and mitoxantrone with the tricarboxylic acid cycle inhibitor devimistat has been reported in a phase I clinical trial with relapsed or refractory acute myeloid leukaemia (AML). Here, the authors report the outcomes of a phase II study, analyse samples from both phases and perform preclinical analyses that show mitochondrial fission or autophagy inhibition sensitizes AML cells to devimistat.

Rebecca Anderson
Lance D. Miller
Timothy S. Pardee
ResearchOpen Access30 Mar 2022
Nature Communications

Volume: 13, P: 1-13
Gut microbiome pattern reflects healthy ageing and predicts survival in humans

Increasing compositional uniqueness of the gut microbiome, and corresponding changes in microbial metabolites in the blood, are identified as a signature of healthy ageing in humans.

Tomasz Wilmanski
Christian Diener
Nathan D. Price
Research18 Feb 2021
Nature Metabolism

Volume: 3, P: 274-286
Timing and scintillation observations of the fast pulsar in CTB80

A. S. Fruchter
J. H. Taylor
A. Wolszczan
Research07 Jan 1988
Nature

Volume: 331, P: 53-54
Urinary metabolite model to predict the dying process in lung cancer patients

Coyle et al. utilize urinary metabolomics analysis to predict dying over the last 30 days of life in patients with lung cancer and provide insights into the dying process. The metabolite model provides prognostic information at the end of life allowing for the early recognition of people who may be dying and improve the care of these patients.

Séamus Coyle
Elinor Chapman
Chris Probert
ResearchOpen Access27 Feb 2025
Communications Medicine

Volume: 5, P: 1-11
Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry

Xueyuan Guo
Juan Du
Jian Zhang
ResearchOpen Access02 Feb 2024
Scientific Reports

Volume: 14, P: 1-15
Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

Human coronavirus-HKU1 contains two surface projections called spike and haemagglutinin-esterase (HE), with the latter acting as a receptor-destroying enzyme. Here, the authors use cryo-EM and mass spectrometry to characterise the small, heavily glycosylated HKU1 HE, revealing a vestigial lectin ___domain covered with a putative glycan shield; and they discuss these features in the context of host adaptation.

Daniel L. Hurdiss
Ieva Drulyte
Raoul J. de Groot
ResearchOpen Access16 Sept 2020
Nature Communications

Volume: 11, P: 1-10
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features

Whole-genome sequencing of chronic lymphocytic leukemia from 485 patients identifies putative coding and noncoding drivers of disease. Genomically defined subgroups show distinct clinical and biological characteristics.

Pauline Robbe
Kate E. Ridout
Anna Schuh
ResearchOpen Access04 Nov 2022
Nature Genetics

Volume: 54, P: 1675-1689
An X-ray pulsar with a superstrong magnetic field in the soft γ-ray repeater SGR1806 − 20

C. Kouveliotou
S. Dieters
T. Murakami
Research21 May 1998
Nature

Volume: 393, P: 235-237
Life expectancy and reproduction

Bernard D. Roitberg
Julie Sircom
Marc Mangel
Research08 Jul 1993
Nature

Volume: 364, P: 108
Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin

Invasive and biomaterial-associated infections in humans are often difficult to diagnose and treat. Here, the authors demonstrate that real-time in vivodetection and imaging of these bacterial infections can be successfully performed with fluorescently labelled vancomycin.

Marleen van Oosten
Tina Schäfer
Gooitzen M. van Dam
Research15 Oct 2013
Nature Communications

Volume: 4, P: 1-8
Instrumental activities of daily living in older patients with metastatic prostate cancer: results from the meet-URO network ADHERE prospective study

Lucia Fratino
Jerry Polesel
Giuseppe Luigi Banna
ResearchOpen Access28 Feb 2024
Scientific Reports

Volume: 14, P: 1-8
Neutron star mass estimates from gamma-ray eclipses in spider millisecond pulsar binaries

A few missing photons in Fermi Gamma-ray Space Telescope observations lead to robust neutron star mass measurements in eclipsing millisecond pulsar binaries, ruling out an ultra-massive pulsar in the original Black Widow system.

C. J. Clark
M. Kerr
G. Voisin
ResearchOpen Access26 Jan 2023
Nature Astronomy

Volume: 7, P: 451-462
Optimal national prioritization policies for hospital care during the SARS-CoV-2 pandemic

Countries are using hospital admission policies that prioritize patients with COVID-19 during the pandemic. The authors propose an alternative open-source framework to optimally schedule hospital care for all diseases and patients that can save life years overall.

Josh C. D’Aeth
Shubhechyya Ghosal
Marisa Miraldo
ResearchOpen Access13 Aug 2021
Nature Computational Science

Volume: 1, P: 521-531
Blood pressure in the longevous population with different status of hypertension and frailty

Takeo Ishii
Kouichi Tamura
Comments & Opinion02 Apr 2024
Hypertension Research

Volume: 47, P: 1738-1740
Foundation dentists’ attitudes and experiences in providing dental care for dependant older adults resident in care home settings

H. Raison
H. Parsley
Y. Dailey
ResearchOpen Access08 Jan 2025
BDJ Open

Volume: 11, P: 1-5
Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice

Heterologous vaccination regimens for COVID-19 could be useful for example if there is a shortage of one vaccine type. Here, Spencer et al. show that heterologous vaccination with a self-amplifying RNA vaccine and an adenoviral vectored vaccine performs at least as well as the homologous vaccinations in mice.

Alexandra J. Spencer
Paul F. McKay
Teresa Lambe
ResearchOpen Access17 May 2021
Nature Communications

Volume: 12, P: 1-8
Final results of the real-life observational VICTOR-6 study on metronomic chemotherapy in elderly metastatic breast cancer (MBC) patients

B. Trevisan
F. F. Pepe
M. E. Cazzaniga
ResearchOpen Access28 Jul 2023
Scientific Reports

Volume: 13, P: 1-9
Impact of frailty on long-term mortality in older patients receiving intensive care via the emergency department

Mototaka Inaba
Hiromichi Naito
Kaoru Masuda
ResearchOpen Access03 Apr 2023
Scientific Reports

Volume: 13, P: 1-9
Occurrence of Discocotyle sagittata on Sea Trout

D. J. SLINN
Research19 Jan 1963
Nature

Volume: 197, P: 306
The Training of Practical Entomologists

A. D. IMMS
Research29 Jul 1920
Nature

Volume: 105, P: 676-677
A network of trans-cortical capillaries as mainstay for blood circulation in long bones

Bone marrow-derived cells can rapidly enter the systemic circulation, but how this is achieved is unclear. Grüneboom et al. identify tiny capillaries, termed trans-cortical vessels (TCVs), that connect the bone marrow cavity to the systemic vasculature, and show that the majority of blood in long bones passes through TCVs.

Anika Grüneboom
Ibrahim Hawwari
Matthias Gunzer
Research21 Jan 2019
Nature Metabolism

Volume: 1, P: 236-250
Samarium hexaboride is a trivial surface conductor

Samarium hexahoride is argued to be a topological Kondo insulator, but this claim remains under debate. Here, Hlawenka et al. provide a topologically trivial explanation for the conducting states at the (100) surface of samarium hexaboride; an explanation based on Rashba splitting and a surface shift of the Kondo resonance.

P. Hlawenka
K. Siemensmeyer
E. D. L. Rienks
ResearchOpen Access06 Feb 2018
Nature Communications

Volume: 9, P: 1-7
Roadmap for alleviating the manifestations of ageing in the cardiovascular system

In this Roadmap, Stellos and colleagues discuss the mechanisms of cardiovascular system ageing and how the ageing of blood, vessels and heart relates to the decline in organ function, and highlight potential therapeutic interventions, challenges in ageing research and future directions for preclinical and clinical studies.

Luca Liberale
Simon Tual-Chalot
Konstantinos Stellos
Reviews19 Feb 2025
Nature Reviews Cardiology

P: 1-29
A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction

Dale D. Hunter
Vandana Shah
Joshua R. Sanes
Research16 Mar 1989
Nature

Volume: 338, P: 229-234
High-resolution VLBA imaging of the radio source Sgr A^* at the Galactic Centre

K. Y. Lo
D. C. Backer
J. M. Moran
Research01 Mar 1993
Nature

Volume: 362, P: 38-40
A Remarkable Ice-Storm

SAMUEL HART
Research05 Feb 1891
Nature

Volume: 43, P: 317-318
Psilocybin therapy for mood dysfunction in Parkinson’s disease: an open-label pilot trial

Ellen R. Bradley
Kimberly Sakai
Joshua D. Woolley
ResearchOpen Access09 Apr 2025
Neuropsychopharmacology

Volume: 50, P: 1200-1209
Influential factors of saliva microbiota composition

Philippa M. Wells
Daniel D. Sprockett
Claire J. Steves
ResearchOpen Access07 Nov 2022
Scientific Reports

Volume: 12, P: 1-11
The Conundrum of Treating de novo metastatic Hormone-Sensitive Prostate Cancer

Tessa van Elst
Niven Mehra
Jean-Paul A. van Basten
ResearchOpen Access11 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
Clonal hematopoiesis impacts frailty in newly diagnosed multiple myeloma patients: a retrospective multicenter analysis

Elisa Gelli
Claudia Martinuzzi
Michele Cea
ResearchOpen Access26 Nov 2024
Scientific Reports

Volume: 14, P: 1-15
A toolbox for the longitudinal assessment of healthspan in aging mice

A series of techniques (echocardiography, novel object recognition, grip strength, rotarod, glucose and insulin tolerance tests, body composition, and energy expenditure) are used to assess the health of mice.

I. Bellantuono
R. de Cabo
D. W. Lamming
Protocols08 Jan 2020
Nature Protocols

Volume: 15, P: 540-574
Recommendations for mitochondria transfer and transplantation nomenclature and characterization

This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation.

Jonathan R. Brestoff
Keshav K. Singh
Minghao Zheng
Reviews16 Jan 2025
Nature Metabolism

Volume: 7, P: 53-67
rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice

Paul Gregorevic
James M Allen
Jeffrey S Chamberlain
Research02 Jul 2006
Nature Medicine

Volume: 12, P: 787-789
Radioiodine for remnant ablation and therapy of metastatic disease

Many questions remain about the efficacy of radioiodine treatment for thyroid remnant ablation and therapy of advanced differentiated thyroid cancer. This Review intends to answer some of these questions taking into account novel insights into the treatment and (re)staging of patients with metastatic disease.

Christoph Reiners
Heribert Hänscheid
Frederik A. Verburg
Reviews09 Aug 2011
Nature Reviews Endocrinology

Volume: 7, P: 589-595
A photometric redshift of z = 6.39 ± 0.12 for GRB 050904

J. B. Haislip
M. C. Nysewander
D. N. Burrows
Research09 Mar 2006
Nature

Volume: 440, P: 181-183
Depression symptoms as longitudinal predictors of the psychological impact of COVID-19 pandemic in hypertensive patients

Marco D’Addario
Francesco Zanatta
Patrizia Steca
ResearchOpen Access13 Aug 2021
Scientific Reports

Volume: 11, P: 1-8
Momentum creation by vortices in superfluid ³He as a model of primordial baryogenesis

T. D. C. Bevan
A. J. Manninen
G. E. Volovik
Research17 Apr 1997
Nature

Volume: 386, P: 689-692
Identification of the nebula G70.7 + 1.2 as a bow shock powered by a pulsar/Be-star binary

S. R. Kulkarni
S. N. Vogel
D. O. S. Wood
Research12 Nov 1992
Nature

Volume: 360, P: 139-141
Inhibition of giant-planet formation by rapid gas depletion around young stars

B. Zuckerman
T. Forveille
J. H. Kastner
Research09 Feb 1995
Nature

Volume: 373, P: 494-496
Phase 2 Randomised Controlled Trial and Feasibility Study of Future Care Planning in Patients with Advanced Heart Disease

Martin A. Denvir
Sarah Cudmore
Kirsty Boyd
ResearchOpen Access19 Apr 2016
Scientific Reports

Volume: 6, P: 1-9
Hematopoietic stem cell transplantation for DLBCL: a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 years

Philipp Berning
Mathilde Fekom
Norbert Schmitz
ResearchOpen Access05 Jul 2024
Blood Cancer Journal

Volume: 14, P: 1-13
Flux pinning, granularity and the irreversibility line of the high-T_c superconductor HgBa₂Cu0_4+x

A. Umezawa
W. Zhang
D. C. Larbalestier
Research08 Jul 1993
Nature

Volume: 364, P: 129-131
Prevention of HIV-1 IIIB infection in chimpanzees by CD4 immunoadhesin

Rebecca H. R. Ward
Daniel J. Capon
Jorg W. Eichberg
Research01 Aug 1991
Nature

Volume: 352, P: 434-436
Hypofractionated radiotherapy in elderly patients (≥75 years) affected by localized prostate cancer: a multicenter retrospective analysis from the IPOPROMISE study

Gianluca Ingrosso
Eleonora Festa
Beatrice Detti
Research17 Mar 2025
Prostate Cancer and Prostatic Diseases

P: 1-8

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