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Storing and protecting organic carbon in agricultural soils requires knowledge on their saturation capacity. Identification of similar pedo-climatic zones allows for creating a risk index informed by the zone-specific effective saturation capacity.

DNA from tumour cells can be detected in the blood of cancer patients. Here, the authors show that cell free DNA fragmentation patterns can identify lung cancer patients and when this information is further interrogated it can be used to predict lung cancer histological subtype.

Hu et al. discovered that the truncated form of human epidermal growth factor receptor 2 (HER2), called p95HER2, drives tumor progression and resistance to the antibody–drug conjugate trastuzumab deruxtecan in HER2⁺ breast cancer. Blocking p95HER2 restores antitumor immunity.

Literature produced inconsistent findings regarding the links between extreme weather events and climate policy support across regions, populations and events. This global study offers a holistic assessment of these relationships and highlights the role of subjective attribution.

Nucleosome profiling from cell-free DNA (cfDNA) represents a potential approach for cancer detection and classification. Here, the authors develop Griffin, a computational framework for tumour subtype classification based on cfDNA nucleosome profiling that can work with ultra-low pass sequencing data.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The emergence of universal collective behaviour is demonstrated through collisions of electron droplets containing up to five particles, which exhibit strong all-body correlations characteristic of a Coulomb liquid.

Label-free and non-destructive infrared near-field microscopy was used to investigate single nanoscale photoswitchable lipid vesicles in water, revealing their chemistry, switching speed and shape transitions below the diffraction limit of light.

Tissue-resident macrophages (TRM) are important mediators of local immunity. Here the authors show that the deficiency or inhibition of a kinase, WNK1, unlinks macrophage colony-stimulating factor signaling and resulted macropinocytosis with the downstream, potentially IRF8-mediated genetic program to bias progenitor differentiation to neutrophil instead of TRM.

Across five randomized controlled trials, Woodley et al. find that a cooperative online quiz game reduced partisan animosity, improved democracy-related attitudes and was highly enjoyable. Effects persisted for up to four months.

Exposure of mice to high fructose during gestation or early postnatal life causes decreased microglial phagocytosis during brain development and leads to anxiety-like behaviour in adolescence.

The authors present experimental evidence of three-dimensional superinsulation in a nanopatterned slab of NbTiN. In the electric Meissner state, they find polar nematic order arising from ferroelectric alignment of short electric strings excited by external electromagnetic fields.

Foetal haematopoiesis takes place in the liver before the bone marrow is seeded. Here the authors used imaging analysis and mouse genetics to look at nascent bone marrow formation and show that yolk-sac-derived myeloid cells promote haematopoiesis by promoting specification of a VCAM1⁺ sinusoidal colonisation niche.

In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

A comparison of alpha diversity (number of plant species) and dark diversity (species that are currently absent from a site despite being ecologically suitable) demonstrates the negative effects of regional-scale anthropogenic activity on plant diversity.

The receptor-like kinase NIK1 is phosphorylated in response to multiple biotic and abiotic signals, activating the NIK1/RPL10/LIMYB signaling circuit, which coordinately regulates translation and photosynthesis in response to environmental changes.

Understanding and preparing for the impacts of climate change on tropical crops is key for global food security and sustainable development, especially in the Global South. This study maps banana production in Latin America and the Caribbean in 2019, and analyses the potential impact of climate change and other factors on banana producing regions.

The orientation of elongated cells often rotates once around the center in tissue. Such structures are called +1 topological defects and play some roles in biological development. By inducing various types of +1 defects in cell layers, the authors found previously overlooked active forces, as the cells gathered at the core of all types of +1 defects.

A large international panel of experts reach consensus on a new standard for reporting settings in psychedelic trials, identifying 30 key non-pharmacological factors to strengthen the rigor of psychedelic research.

The 2016 peace agreement in Colombia led to agricultural expansion to the detriment of biodiversity. Using Colombia as a case study, this work shows how to maximize the biodiversity benefits from limited conservation funding while landowners maintain economic returns equivalent to those from agriculture.

Pythium sensu lato (s.l.) is an oomycete that poses a serious threat to agricultural production worldwide. This study, using metabarcoding, provides insights into the diverse soil communities of Pythium s.l. across 127 locations and their disease potential in European corn fields.

The capillarity-driven uptake of liquids by porous solids can be experienced in daily life, e.g., when a sponge imbibes water. Here, the authors demonstrate that this process can be switched on and off reversibly when nanoporous gold takes the role of the sponge and an electric potential is used to control the surface tension.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

Heavier analogues of unsaturated organic molecules are of interest because of their bonding situation and their potential use in synthesis. Now, a Bi(I)-based allyl cation, which can be seen as a heavy congener of all-carbon π-allyl cations, has been reported. This complex serves as a synthon for Bi(I) transfer, enabling access to low-valent organobismuth compounds.

Extracellular anisotropic stresses trigger fibroblast transition into myofibroblasts by the mechanical self-reinforcement of cell–extracellular matrix interactions.

Here the authors apply ZooMS, radiocarbon, and stable isotope analyses to whale bones from the Bay of Biscay. They find that humans were utilizing the remains of at least five species of whales from 20,000 years ago, and that those whale communities may have resembled today’s arctic waters.

The development of electronic flying qubits requires the ability to generate and control single-electron excitations. Here the authors demonstrate quantum coherence of ultrashort single-electron plasmonic pulses in an electronic Mach-Zehnder interferometer, revealing a non-adiabatic regime at high frequencies.

Stereotactic needle biopsies are currently performed for diagnosis only in glioblastoma; this study highlights the depth of information available through multi-omics analysis.

This Review explores in detail the complexity of NK cell biology in humans and highlights the role of these cells in cancer immunity.