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Scientific Reports (73)
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Showing 1–50 of 202 results

Advanced filters: Author: Dali Li Clear advanced filters

Substantial spillover burden of rat hepatitis E virus in humans

Rat hepatitis E virus (HEV) can infect humans, but the extent of spillover isn’t well studied. Here the authors develop a serological test that distinguishes exposure to rat HEV from other HEV infection and show substantial spillover in a biodiversity hotspot in China. The method can support surveillance of rat HEV.

Zihao Chen
Lifeng Wang
Zizheng Zheng
ResearchOpen Access29 Apr 2025
Nature Communications

Volume: 16, P: 1-17
Intangible cultural heritage threatened-level categories and criteria

Na Li
Xiaokang Li
Wen Xiao
ResearchOpen Access27 Feb 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-11
Planar asymmetric surface Fe^IV = O synthesis with pyrite and chlorite for efficient oxygen atom transfer reactions

Surface high-valent iron-oxo species (≡Fe⁴⁺=O) are effective and environmentally friendly reagents for oxygen atom transfer. Here, the authors create a planar, asymmetric ≡Fe⁴⁺=O with a Fe–Cl₁S₃ structure using pyrite and chlorite, which enhances electron delocalization and weakens the Fe=O bond to improve reaction efficiency.

Wengao Lian
Hengyue Xu
Lizhi Zhang
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-8
Periplaneta americana extract improves recurrent oral ulcers through regulation of TLR4/NF-κB and Nrf2/HO-1 pathways

Weijun Li
Yi Chen
Yongshou Yang
ResearchOpen Access12 Mar 2025
Scientific Reports

Volume: 15, P: 1-17
Efficient mitochondrial A-to-G base editors for the generation of mitochondrial disease models

Efficient adenine base editors for mitochondrial DNA are achieved with evolved TadA deaminases.

Liang Chen
Mengjia Hong
Dali Li
Research03 Jun 2025
Nature Biotechnology

P: 1-12
Unravelling the hidden link of lithium halides and application in the synthesis of organocuprates

Organocopper species are widely used in synthetic chemistry. Here the authors study the structure of the anionic complex formed from copper salts and lithium halides, showing it to be a key intermediate in the formation of organocuprates, and also show that Cu(II) precursors can form Gilman reagents.

Hong Yi
Dali Yang
Aiwen Lei
ResearchOpen Access16 Mar 2017
Nature Communications

Volume: 8, P: 1-6
The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer

Lu and colleagues show that signaling through the lactate receptor HCAR1 in colorectal tumor cells promotes the recruitment of immunosuppressive CCR2⁺ PMN-MDSCs and that inhibition of HCAR1 by reserpine augments the CD8⁺ T cell-mediated antitumor immune response.

Jiacheng He
Xiaolei Chai
Weiqiang Lu
Research04 Feb 2025
Nature Immunology

Volume: 26, P: 391-403
A mitochondrial disease model is generated and corrected using engineered base editors in rat zygotes

A mitochondrial disease is modeled using engineered base editors in rats.

Liang Chen
Changming Luan
Dali Li
Research03 Jun 2025
Nature Biotechnology

P: 1-5
Engineering a photoactivatable A-to-I RNA base editor for gene therapy in vivo

A light-inducible RNA base editor fine-tunes gene expression for therapeutics.

Huiying Li
Yuhao Qiu
Dali Li
Research31 Mar 2025
Nature Biotechnology

P: 1-12
Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype

Single cell transcriptomic sequencing (scRNA) can identify genes that are differentially expressed in cell populations in specific diseases. Here the authors perform scRNA sequencing in a high-altitude pulmonary hypertension (HAPH) cohort and show transcriptional differences in monocyte populations.

Xin-Hua Wu
Yang-Yang He
Zhi-Cheng Jing
ResearchOpen Access31 Mar 2023
Nature Communications

Volume: 14, P: 1-14
Long non-coding RNA NEAT1 promotes colorectal cancer progression via interacting with SIRT1

Yuwei Li
Yunchun Xu
Le Guo
ResearchOpen Access15 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Vorinostat attenuates UVB-induced skin senescence by modulating NF-κB and mTOR signaling pathways

Qianlong Dai
Zhiwei Wang
Jianjie Cheng
ResearchOpen Access29 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
Insights into the mitochondrial genome structure and phylogenetic placement of Theileria velifera in comparison to other apicomplexan parasites

Xing Yang
Shaobo Tang
Chunhong Du
ResearchOpen Access27 Mar 2025
Scientific Reports

Volume: 15, P: 1-12
Taraxasterol suppresses the proliferation and tumor growth of androgen-independent prostate cancer cells through the FGFR2-PI3K/AKT signaling pathway

Jinqiu Yang
Chulin Xin
Juan Li
ResearchOpen Access11 Aug 2023
Scientific Reports

Volume: 13, P: 1-10
FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway

Alveolar bone resorption (ABR) is a key pathological manifestation in the development of apical periodontitis (AP) that contributes to the AP-associated tooth loss, and whose underlying mechanism is largely unknown. Here, the authors show a molecular mechanism on osteoclastogenesis-related ABR and provides a therapeutic target of AP via modulating the FTO/HK1/USP14/RANK axis.

Yajie Qian
Jing Wu
Deyan Chen
ResearchOpen Access11 Feb 2025
Nature Communications

Volume: 16, P: 1-19
Watershed: a more efficient sampling unit for mountain camera traps

Jun-Jie Li
Yi-Hao Fang
Wen Xiao
ResearchOpen Access04 Feb 2025
Scientific Reports

Volume: 15, P: 1-13
A real-world pharmacovigilance study of lorazepam based on the FDA adverse event reporting system database

Chunyue Fang
Xiaoyan Xu
Ruixiang Chen
ResearchOpen Access24 Jun 2025
Scientific Reports

Volume: 15, P: 1-14
Association of WHSC1/NSD2 and T-cell infiltration with prostate cancer metastasis and prognosis

Qiheng Li
Jiang Zhu
Chunmei Zhang
ResearchOpen Access07 Dec 2023
Scientific Reports

Volume: 13, P: 1-20
Long-read sequencing of 945 Han individuals identifies structural variants associated with phenotypic diversity and disease susceptibility

Genetic studies of Chinese individuals have been performed, but mostly with short read sequencing, limiting the types of variants that can be identified. Here, the authors perform long read sequencing of 945 han Chinese individuals, finding structural variants under natural selection and those associated with human traits and evolutionary history.

Jiao Gong
Huiru Sun
Shaohua Fan
ResearchOpen Access10 Feb 2025
Nature Communications

Volume: 16, P: 1-21
Cryo-EM structure of an activated GPR4–Gs signaling complex

The proton-sensing GPCRs detect extracellular low pH and regulate diverse physiological responses. Here, the authors report cryo-EM structures of GPR4, which provide insight into the structural features of proton sensing mechanism.

Yitong Ma
Yijie Wang
Gaojie Song
ResearchOpen Access11 Jan 2025
Nature Communications

Volume: 16, P: 1-10
Dynamic boron-doping switched chitin-based single-atom Pt catalyst for chemo-selective hydrogenation

Biomass valorization is a way to promote the ‘waste-to-wealth’ concept, which is a prerequisite condition for a future sustainable lifestyle. Here, the authors demonstrate a methodology to prepare chitin-derived supramolecular nanowires-stabilized single-atom site platinum catalysts.

Yan Li
Lijun Lu
Aiwen Lei
ResearchOpen Access07 Mar 2025
Nature Communications

Volume: 16, P: 1-9
Oleanolic acid improves 5-fluorouracil-induced intestinal damage and inflammation by alleviating intestinal senescence

Shi-rui Bai
Bing-xiang Zhao
Xiao-bo Wang
ResearchOpen Access19 Sept 2024
Scientific Reports

Volume: 14, P: 1-15
Resolvin D1 combined with exercise rehabilitation alleviates neurological injury in mice with intracranial hemorrhage via the BDNF/TrkB/PI3K/AKT pathway

Lv Xiaoyu
Li Dandan
Zhang Bensi
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-17
High-rate lithiation-induced reactivation of mesoporous hollow spheres for long-lived lithium-ion batteries

Hollow structured materials are promising electrodes for energy storage, but still suffer from mechanical and chemical degradations in operation. Here, the authors show that upon high-rate lithiation reactivation, hierarchically mesoporous structures can be created to mitigate the degradations.

Hongtao Sun
Guoqing Xin
Jie Lian
Research31 Jul 2014
Nature Communications

Volume: 5, P: 1-8
Author Correction: The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer

Jiacheng He
Xiaolei Chai
Weiqiang Lu
Amendments and Corrections10 Mar 2025
Nature Immunology

Volume: 26, P: 635
No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population

Wan-Ying Liang
Li-Hong Wang
Li-Hua Li
ResearchOpen Access27 Jan 2021
Scientific Reports

Volume: 11, P: 1-8
Smoking, alcohol consumption and corneal biomechanical parameters among Chinese university students

Min-Xin Liu
Dan-Lin Li
Chen-Wei Pan
Research25 Jan 2023
Eye

Volume: 37, P: 2723-2729
Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice

Individuals with SYK gain-of-function variants develop immunodeficiency and systemic inflammation, which are recapitulated in a knock-in mouse model. Treatment of these mice with bone marrow transplantation or with a SYK inhibitor ameliorates disease symptoms, highlighting potential therapeutic strategies for patients with SYK mutations.

Lin Wang
Dominik Aschenbrenner
Aleixo M. Muise
Research29 Mar 2021
Nature Genetics

Volume: 53, P: 500-510
RNA m⁶A involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells

Nan Zhang
Jie Yang
Shiyan Gu
ResearchOpen Access10 Jan 2025
Cell Death Discovery

Volume: 11, P: 1-15
Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL

Non-viral CAR-T cells with gene-specific targeted integration are safe and effective in patients with lymphoma.

Jiqin Zhang
Yongxian Hu
He Huang
ResearchOpen Access31 Aug 2022
Nature

Volume: 609, P: 369-374
Atorvastatin calcium alleviates UVB-induced HaCat cell senescence and skin photoaging

Man Li
Yuchen Ge
Min Zhou
ResearchOpen Access03 Dec 2024
Scientific Reports

Volume: 14, P: 1-10
Small-scale alpine topography at low latitudes and high altitudes: refuge areas of the genus Chrysanthemum and its allies

Xi Chen
Haibin Wang
Fadi Chen
ResearchOpen Access01 Nov 2020
Horticulture Research

Volume: 7, P: 1-12
The chloroplast genomes of two medicinal species (Veronica anagallis-aquatica L. and Veronica undulata Wall.) and its comparative analysis with related Veronica species

Yonglin Hai
Yan Qian
Conglong Xia
ResearchOpen Access17 Jun 2024
Scientific Reports

Volume: 14, P: 1-18
Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

Liang Chen
Mengjia Hong
Dali Li
Amendments and Corrections24 Apr 2024
Nature Biotechnology

Volume: 42, P: 987
Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Liang Chen
Biyun Zhu
Dali Li
Amendments and Corrections24 Apr 2024
Nature Biotechnology

Volume: 42, P: 987
Antioxidant and anti-inflammatory function of Eupatorium adenophora Spreng leaves (EASL) on human intestinal Caco-2 cells treated with tert-butyl hydroperoxide

Li Zheng-qiang
Ni Jun
Yang Xiao-yan
ResearchOpen Access07 May 2024
Scientific Reports

Volume: 14, P: 1-14
HIF-1α knockdown attenuates phenotypic transformation and oxidative stress induced by high salt in human aortic vascular smooth muscle cells

Wenbin Deng
Shiqiong Huang
Lihua Li
ResearchOpen Access15 Nov 2024
Scientific Reports

Volume: 14, P: 1-11
CRISPR–Cas9-mediated gene editing of the BCL11A enhancer for pediatric β⁰/β⁰ transfusion-dependent β-thalassemia

Preliminary results from a phase 1/2 trial with 18-month follow-up show that transplantation of CRISPR–Cas9 BCL11A-edited autologous hematopoietic cells in two children with β-thalassemia was safe and achieved transfusion independence.

Bin Fu
Jiaoyang Liao
Yuxuan Wu
Research04 Aug 2022
Nature Medicine

Volume: 28, P: 1573-1580
Extinction drives a discontinuous temporal pattern of species–area relationships in a microbial microcosm system

Wei Deng
Na Li
Wen Xiao
ResearchOpen Access06 Mar 2023
Scientific Reports

Volume: 13, P: 1-9
Electrocatalytic reductive deuteration of arenes and heteroarenes

Reductive deuteration and deuterodefluorination of arenes and heteroarenes is achieved through a scalable and general electrocatalytic method using a nitrogen-doped ruthenium electrode and heavy water.

Faxiang Bu
Yuqi Deng
Aiwen Lei
Research29 Aug 2024
Nature

Volume: 634, P: 592-599
Corneal stress‒strain index in relation to retinal nerve fibre layer thickness among healthy young adults

Min-Xin Liu
Dan-Lin Li
Chen-Wei Pan
Research24 Feb 2024
Eye

Volume: 38, P: 1654-1659
Author Correction: Engineering a precise adenine base editor with minimal bystander editing

Liang Chen
Shun Zhang
Dali Li
Amendments and Corrections22 Apr 2024
Nature Chemical Biology

Volume: 20, P: 1094
Structure of the mechanosensitive OSCA channels

Cryo-EM and electrophysiological studies of two mechanosensitive OSCA channels from Arabidopsis thaliana reveal their structural similarity to osmosensitive TMEM16 channels and suggest they are gated by force from lipid in response to osmotic stress.

Mingfeng Zhang
Dali Wang
Lei Chen
Research06 Sept 2018
Nature Structural & Molecular Biology

Volume: 25, P: 850-858
Ecological filtering shapes the impacts of agricultural deforestation on biodiversity

The authors collate literature on the responses of bird assemblages to forest loss and show that locations with a more variable natural environment and a longer history of agricultural land use have bird assemblages that are more tolerant to forest loss.

Fangyuan Hua
Weiyi Wang
Paul R. Elsen
Research05 Jan 2024
Nature Ecology & Evolution

Volume: 8, P: 251-266
Author Correction: Characterization of a filovirus (Měnglà virus) from Rousettus bats in China

Xing-Lou Yang
Chee Wah Tan
Zheng-Li Shi
Amendments and Corrections08 Feb 2019
Nature Microbiology

Volume: 4, P: 543
Correlated evolution of social organization and lifespan in mammals

To elucidate the relationship between sociality and longevity, the authors perform phylogenetic and transcriptomic comparative analysis of mammals. They find that group-living species lived longer than solitary species and identify 31 genes, hormones, and immunity-related pathways involved in this connection.

Pingfen Zhu
Weiqiang Liu
Xuming Zhou
ResearchOpen Access31 Jan 2023
Nature Communications

Volume: 14, P: 1-18
Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery

Cepharanthine is a secondary metabolite isolated from Stephania with a variety of medicinal properties. Here, the authors assembled three Stephania genomes, propose cepharanthine biosynthetic pathway, and assess the antiviral potential of cepharanthine-related metabolites.

Liang Leng
Zhichao Xu
Shilin Chen
ResearchOpen Access20 Feb 2024
Nature Communications

Volume: 15, P: 1-16
PM_2.5 exposure modifies the association of physical activity with depressive symptoms and glaucoma in middle aged and elderly Chinese

Xianzhi Li
Yajie Li
Xiangyi Xing
ResearchOpen Access23 Apr 2025
Scientific Reports

Volume: 15, P: 1-10
Correlation of BUB1 and BUB1B with the development and prognosis of endometrial cancer

Huicong Zhang
yuhao li
Huixia Lu
ResearchOpen Access24 Jul 2024
Scientific Reports

Volume: 14, P: 1-11
Neuronal enhancers are hotspots for DNA single-strand break repair

DNA single-strand breaks in neurons accumulate at high levelsin functional enhancers.

Wei Wu
Sarah E. Kargbo-Hill
André Nussenzweig
Research25 Mar 2021
Nature

Volume: 593, P: 440-444

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