Non-enzymatic HPA reduces mTOR expression and inhibits TFEB phosphorylation, resulting in dissociation of mTOR binding to 14-3-3 protein. The dephosphorylated TFEB is subsequently translocated into the nucleus and activates the expression of autophagy and lysosomal genes which promote the autophagic process and thereby aggravate the growth of gastric cancer cells.
- Min Yang
- Bo Tang
- Shi-Ming Yang
