Nature Search

Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer

Using pancreatic organoids and genetic mouse models, Antonucci et al. show that cellular stress activates an NRF2–EZH2 epigenetic axis leading to metabolic reprogramming and subsequent malignant transformation of KRAS-mutant benign lesions.

Laura Antonucci
Na Li
Michael Karin
Research30 Jun 2025
Nature Cancer

P: 1-20
Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein

William G. Rice
Jim A. Turpin
Edward A. Sausville
Research01 Mar 1997
Nature Medicine

Volume: 3, P: 341-345
The mutagenic forces shaping the genomes of lung cancer in never smokers

An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as air pollution and passive smoking.

Marcos Díaz-Gay
Tongwu Zhang
Maria Teresa Landi
Research02 Jul 2025
Nature

P: 1-12
Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses

Lipid nanoparticles (LNPs) delivering mRNA after intratumoral administration could be a promising cancer treatment strategy. Here this group reports the intratumoral delivery of mRNA with LNPs inducing the expression of purine nucleoside phosphorylase and inhibiting the progression of head and neck squamous cell carcinoma in vivo.

Sebastian G. Huayamares
Liming Lian
James E. Dahlman
ResearchOpen Access12 Apr 2025
Nature Communications

Volume: 16, P: 1-14
Mechanism of cytarabine-induced neurotoxicity

Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas less neurotoxic agents induce single-stranded breaks.

Jia-Cheng Liu
Dongpeng Wang
André Nussenzweig
Research25 Jun 2025
Nature

P: 1-10
The human pseudoautosomal GM–CSF receptor α subunit gene is autosomal in mouse

Christine M. Disteche
Camilynn I. Brannan
Linda S. Park
Research01 Aug 1992
Nature Genetics

Volume: 1, P: 333-336
erratum Genome sequence of enterohaemorrhagic Escherichia coli 0157:H7

Nicole T. Perna
Guy Plunkett III
Frederick R. Blattner
Research08 Mar 2001
Nature

Volume: 410, P: 240
Rutherford and Nuclear Power

DAVID A. KEYS
Research02 Mar 1963
Nature

Volume: 197, P: 842-843
SP140–RESIST pathway regulates interferon mRNA stability and antiviral immunity

The antiviral protein SP140 negatively regulates Ifnb1 mRNA stability by directly repressing the expression of the immune regulator RESIST.

Kristen C. Witt
Adam Dziulko
Russell E. Vance
ResearchOpen Access11 Jun 2025
Nature

P: 1-9
APOBEC affects tumor evolution and age at onset of lung cancer in smokers

APOBEC mutational signatures are commonly found in multiple cancer types. Here, the authors utilize multi-omics analyses to reveal that the cooccurrence of APOBEC associated mutagenesis and tobacco-smoking-related mutations affects lung tumor evolution and age at onset of lung cancer from smokers.

Tongwu Zhang
Jian Sang
Maria Teresa Landi
ResearchOpen Access21 May 2025
Nature Communications

Volume: 16, P: 1-17
An international Delphi consensus for reporting of setting in psychedelic clinical trials

A large international panel of experts reach consensus on a new standard for reporting settings in psychedelic trials, identifying 30 key non-pharmacological factors to strengthen the rigor of psychedelic research.

Chloé Pronovost-Morgan
Kyle T. Greenway
Keith Williams
ResearchOpen Access03 Jun 2025
Nature Medicine

P: 1-10
Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome

Here, the authors suggest that nitric oxide (NO) is an endogenous epigenetic regulator of gene expression by inhibiting DNA demethylation enzymes (TET and ALKBH2) and increasing DNA methylation at gene regulatory loci throughout the genome.

Marianne B. Palczewski
Hannah Petraitis Kuschman
Douglas D. Thomas
ResearchOpen Access18 Feb 2025
Nature Communications

Volume: 16, P: 1-18
Gabapentinoids confer survival benefit in human glioblastoma

In preclinical studies, the FDA approved TSP-1 antagonist gabapentin has been shown to disrupt neuronal-glioma interactions, slowing glioblastoma progression. Here, authors report a retrospective cohort study demonstrating a survival benefit associated with gabapentin in patients with newly diagnosed glioblastoma.

Joshua D. Bernstock
Mulki Mehari
Shawn L. Hervey-Jumper
ResearchOpen Access15 May 2025
Nature Communications

Volume: 16, P: 1-6
Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

Michael K. Lee
David R. Borchelt
Sangram S. Sisodia
Research01 Jul 1997
Nature Medicine

Volume: 3, P: 756-760
Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

Production of inflammatory mediators by M1-polarized macrophages is thought to rely on suppression of mitochondrial metabolism in favor of glycolysis. Refining this concept, here the authors define metabolic targets of nitric oxide as responsible for the mitochondrial rewiring resulting from polarization.

Erika M. Palmieri
Marieli Gonzalez-Cotto
Daniel W. McVicar
ResearchOpen Access04 Feb 2020
Nature Communications

Volume: 11, P: 1-17
Psychological, social, and health-related factors predict risk for financial exploitation

Results from three studies that examined 1918 U.S. adults show that financial exploitation risk is heightened by a complex interplay of sociodemographic, health, cognitive, and psychosocial vulnerabilities.

Yi Yang
Katherine Hackett
David V. Smith
ResearchOpen Access05 Jun 2025
Communications Psychology

Volume: 3, P: 1-16
A comprehensive genetic map of the mouse genome

William F. Dietrich
Joyce Miller
Eric S. Lander
Research14 Mar 1996
Nature

Volume: 380, P: 149-152
Editorial Expression of Concern: A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

Cory M. Johannessen
Laura A. Johnson
Levi A. Garraway
Amendments and Corrections24 Apr 2025
Nature

Volume: 641, P: E7
Investigative needle core biopsies support multimodal deep-data generation in glioblastoma

Stereotactic needle biopsies are currently performed for diagnosis only in glioblastoma; this study highlights the depth of information available through multi-omics analysis.

Kenny K. H. Yu
Sreyashi Basu
Nathalie Y. R. Agar
ResearchOpen Access28 Apr 2025
Nature Communications

Volume: 16, P: 1-23
The burden of proof in linking AIDS to scrapie

MICHAEL J. BRAUN
MATTHEW A. GONDA
STANLEY B. PRUSINER
Research10 Dec 1987
Nature

Volume: 330, P: 525-526
Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics

Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive heterogeneity and microenvironmental co-evolution.

Avishay Spitzer
Kevin C. Johnson
Mario L. Suvà
ResearchOpen Access09 May 2025
Nature Genetics

Volume: 57, P: 1168-1178
The multilayered transcriptional architecture of glioblastoma ecosystems

Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with specific mutations that form three stereotypical ecosystems.

Masashi Nomura
Avishay Spitzer
Itay Tirosh
ResearchOpen Access09 May 2025
Nature Genetics

Volume: 57, P: 1155-1167
The potential for differentiated vehicle segment tariffs

Ming Liu
Han Hao
Fuquan Zhao
Correspondence20 Jun 2025
Nature Energy

P: 1-3
SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination

The rapid waning of SARS-CoV-2-specific serum antibodies observed after immunization with COVID-19 mRNA vaccines may be accounted for by the absence of long-lived plasma cells in the bone marrow specific for the virus.

Doan C. Nguyen
Ian T. Hentenaar
F. Eun-Hyung Lee
ResearchOpen Access27 Sept 2024
Nature Medicine

Volume: 31, P: 235-244
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

Jun Fang
Jinping Jia
Laufey T. Amundadottir
ResearchOpen Access27 Apr 2017
Nature Communications

Volume: 8, P: 1-17
The principal eyes of a jumping spider have a telephoto component

David S. Williams
Peter MeIntyre
Research11 Dec 1980
Nature

Volume: 288, P: 578-580
Localized perturbations in CheY structure monitored by NMR identify a CheA binding interface

Ronald V. Swanson
David F. Lowry
Frederick W. Dahlquist
Research01 Oct 1995
Nature Structural Biology

Volume: 2, P: 906-910
HIV-1 suppression and rare dolutegravir resistance in antiretroviral-experienced people with HIV in Liberia

Moses et al. undertake a cross-sectional study on more than 1200 individuals living in Liberia with HIV and receiving antiretroviral therapy. They show that different antiviral treatment regimens and other factors effect virological failure rate and the prevalence of drug resistance.

James Soka Moses
Alice K. Pau
Stephen A. Migueles
ResearchOpen Access09 May 2025
Communications Medicine

Volume: 5, P: 1-10
Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming

Nitric oxide has been shown to target mitochondrial aconitase 2 and pyruvate dehydrogenase to reprogramme macrophage metabolism. Here, the authors extend these findings to show that lipoate is used to generate nitroxyl in this process.

Erika M. Palmieri
Ronald Holewinski
Daniel W. McVicar
ResearchOpen Access22 Aug 2023
Nature Communications

Volume: 14, P: 1-21
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

Barbara L. Hempstead
Dionisio Martin-Zanca
Moses V. Chao
Research25 Apr 1991
Nature

Volume: 350, P: 678-683
Correlative genetic variation in natural populations of cats, mice and men

Stephen J. O'Brien
Mitchell H. Gail
David L. Levin
Research11 Dec 1980
Nature

Volume: 288, P: 580-583
Mediation of mouse natural cytotoxic activity by tumour necrosis factor

John R. Ortaldo
Llewellyn H. Mason
Ronald B. Herberman
Research12 Jun 1986
Nature

Volume: 321, P: 700-702
Reactive oxygen species-related oxidative changes are associated with splenic lymphocyte depletion in Ebola virus infection

Venkatesh Mani
Winston T. Chu
Eric Gale
ResearchOpen Access24 Apr 2025
npj Imaging

Volume: 3, P: 1-13
Evolution of the Galapagos Finches

DAVID LACK
Research07 Sept 1940
Nature

Volume: 146, P: 324-327
Science and Universities

JOSEPH BEN-DAVID
Research12 Jul 1969
Nature

Volume: 223, P: 137-139
Correction: Corrigendum: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

Eileen M Shore
Meiqi Xu
Frederick S Kaplan
Amendments and Corrections01 Feb 2007
Nature Genetics

Volume: 39, P: 276
Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling

This work integrates duplex sequencing with cost-effective Ultima sequencing to enhance the accuracy of whole-genome circulating cell-free DNA profiling.

Alexandre Pellan Cheng
Adam J. Widman
Dan A. Landau
Research11 Apr 2025
Nature Methods

Volume: 22, P: 973-981
2023 International Rome consensus for the nomenclature of Sjögren disease

In this Consensus Statement, an international group of experts and patient representatives validates and endorses the transition from the term ‘Sjögren syndrome’ to ‘Sjögren disease’, and issue several additional recommendations regarding the nomenclature of this disorder.

Manuel Ramos-Casals
Alan N. Baer
Arjan Vissink
Reviews10 Jun 2025
Nature Reviews Rheumatology

Volume: 21, P: 426-437
On-demand formation of Lewis bases for efficient and stable perovskite solar cells

Lewis acid additive semicarbazide hydrochloride improves the formation of α-phase FAPbI₃-based films and promotes a homogeneous vertical distribution of A-site cations through a deprotonation–reprotonation process. The upgraded device performance reaches up to 26.12% with high stability, and mini-module perovskite solar cells achieving 21.47% (area, 11.52 cm²) demonstrate great scalability.

Sheng Fu
Nannan Sun
Yanfa Yan
Research17 Apr 2025
Nature Nanotechnology

Volume: 20, P: 772-778
Hazards of the Road

DAVID NAPLEY
Research29 Sept 1962
Nature

Volume: 195, P: 1242-1245
Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases

In this immunological ancillary study of the PREVAC trial, the authors show that approved Ebola virus vaccines induce memory T-cell responses that persist during the five year follow-up after initial vaccination.

Aurélie Wiedemann
Edouard Lhomme
Huanying Zhou
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-15
Identification of an interferon in murine placentas

Arnold K. Fowler
Carl D. Reed
David J. Giron
Research17 Jul 1980
Nature

Volume: 286, P: 266-267
Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2

The SIT1-ACE2 complex transports the amino acid proline and is the receptor of SARS-CoV-2. Here, the authors identify specific sequence requirements for proline transport and explain for how a missense mutation causes iminoglycinuria.

Huanyu Z. Li
Ashley C. W. Pike
David B. Sauer
ResearchOpen Access29 Jun 2024
Nature Communications

Volume: 15, P: 1-11
Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model

Mutations that enhance the activity of protein kinase C alpha (PKCα) are associated with Alzheimer’s Disease. Here, the authors report that the enhanced activity of one variant, PKCα M489V, is sufficient to rewire the brain phosphoproteome, drive synaptic degeneration, and impair cognition in a mouse model.

Gema Lordén
Jacob M. Wozniak
Alexandra C. Newton
ResearchOpen Access23 Nov 2022
Nature Communications

Volume: 13, P: 1-16
Complete genomic characterization of global pathogens respiratory syntical virus and human norovirus using probe based capture enrichment

Sravya V Bhamidipati
Anil Surathu
Harsha Doddapaneni
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Lymphocyte activation by HIV-1 envelope glycoprotein

Hardy Kornfeld
William W. Cruikshank
David M. Center
Research29 Sept 1988
Nature

Volume: 335, P: 445-448
Second-Hand Stress: Neurobiological Evidence for a Human Alarm Pheromone

Lilianne Mujica-Parodi
Helmut Strey
Jochen Weber
ResearchOpen Access25 Nov 2008
Nature Precedings

P: 1
The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells

Karen B. Avraham
Tama Hasson
Nancy A. Jenkins
Research01 Dec 1995
Nature Genetics

Volume: 11, P: 369-375
Variants in the WDR44 WD40-repeat ___domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation

A vesicle trafficking Rab11 effector switch is important for ciliogenesis. Here, the authors report a ciliopathy-related disorder caused by variants in WDR44, a Rab11 effector. WDR44 variants show higher affinity for Rab11 and can impair ciliogenesis.

Andrea Accogli
Saurabh Shakya
Christopher J. Westlake
ResearchOpen Access08 Jan 2024
Nature Communications

Volume: 15, P: 1-20
KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma

There is lack of therapies targeting the PAX3-FOXO1 fusion oncogene in fusion-positive rhabdomyosarcoma (FP-RMS). Here, the authors identify and characterise an inhibitor with highest inhibition of histone lysine demethylase 3B that suppresses PAX3-FOXO1 activity in FP-RMS.

Yong Yean Kim
Berkley E. Gryder
Javed Khan
ResearchOpen Access24 Feb 2024
Nature Communications

Volume: 15, P: 1-19

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