Search

Tilgner et al. demonstrated the formation of the quantum spin Hall insulator bismuthene on SiC, intercalated underneath a protective graphene layer. A hydrogen-induced orbital filtering effect is the driving force behind this reversible phase transition.

While the synthesis of hollow structures of transition metal oxides is well established, the related sulfide chemistry remains challenging. Here, the authors report the synthesis of nickel cobalt sulfide ball-in-ball hollow spheres, via anion exchange, and evaluate their pseudocapacitive behaviour.

As US high energy physicists bemoan a continued tightness of funds, West Coast scientists are proposing an ingenious way of keeping up with European colleagues — at a fraction of the cost. David Dickson reports

The collision of an atom and a diatomic molecule may sound like a simple process but it has long been studied to understand the inherent intricacies of collisional energy transfer. Now, experiments carried out in unprecedented detail on the scattering of NO by Ar have revealed further complexity: parity-dependent quantum interference effects.

Some autistic individuals experience aversion to social touch. Authors use Neuropixels probes and demonstrate that unlike wild type mice, Fmr1 knockout mice find social and non-social interactions equally aversive, and their cortical and striatal neurons are less able to discriminate social valence.

Monomethylation of histone H4 lysine 20 (H4K20me1) contributes to DNA replication but the mechanism is not well understood. Here, the authors identify a conserved tandem Tudor ___domain of BAHCC1 as a H4K20me1-specific reader, which promotes the recruitment of MCM complex to chromatin for efficient DNA replication.

Colored functional layers are transformed into imperceptible functional meshes. In doing so, various see-through devices are no longer susceptible to the color or opacity of the functional materials and have enhanced transparency.

Pocock et al. reveal that transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor drives robust maturation of multicellular human cardiac organoids, enabling modeling of desmoplakin cardiomyopathy dysfunction, which could be rescued using the bromodomain and extra-terminal inhibitor INCB054329.

In bat CA1, the authors found contextual time cells encoding spatial context and time, another population purely encoding elapsed time and social time cells encoding sequences aligned to another bat’s landing in a social imitation task.

Every spring, Bogong moths use the starry night sky as a compass to navigate up to 1,000 km towards their alpine migratory goal.

DNA hybridisation thermodynamics parameters underlie rational design of oligonucleotides for diagnostics and nanotechnology. Here, the authors present an accurate method to measure the free energy of a given DNA structure at specific temperature and buffer conditions.

Zhang et al. provide evidence that, during meiosis, recombination proteins assemble into active droplets, the coarsening of which partially explains the phenomenon of crossover interference.

A polymorphism present in about half the general population can predispose to heart failure as well as enhance responsiveness to β-blockers. The mechanism for this is now being revealed (pages 1300–1305).

Subducted slabs may experience transient weakening during mineral phase transitions, consistent with slab stagnation in the mantle transition zone, according to a synchrotron beamline study of the quartz-to-coesite and olivine-to-ringwoodite phase transitions.

Targeting a non-natural micropeptide ‘killswitch’ to several biomolecular condensates altered condensate compositions and revealed condensate functions in human cells

The authors observe a reduction in thermal conductivity when transitioning from single to multi-cation oxides, exploring the role of local bonding distortions in phonon scattering and thermal transport.

Agricultural runoff adds sulfate to Florida wetlands, which increases production of toxic methylmercury at moderate sulfate concentrations that is assimilated in fish. The study helps predict wetland responses to management and climate variables.

Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially resolved single-cell atlas of human fetal cortical development.

Dynamic interface printing is a new form of 3D printing that leverages an acoustically modulated, constrained air–liquid boundary to rapidly generate centimetre-scale 3D structures within tens of seconds.

Chandelier cells organize neural coding and mediate learning by establishing inhibitory circuit motifs over individual pyramidal neurons and suppressing irrelevant activity via adaptive axo-axonic synaptic plasticity, subserving efficient computation.

DNAJC12 variants cause parkinsonism. Here, the authors show that DNAJC12 stabilizes tyrosine hydroxylase, a crucial enzyme in dopamine synthesis, and identify key structural motifs for this interaction, explaining the pathogenesis of truncated variants.

The authors developed a patient-specific microphysiological system using the LumeNEXT microfluidic platform to more accurately recreate the prostate cancer metastatic bone tumor microenvironment.

Acquiring biomarkers from blood or sweat is limited by invasiveness or biofouling. Skin gas emissions bypass these issues, offering rich biosignals. Authors present passive sensing strategies capturing water vapor (Sweat rate), CO2, and VOCs, enabling real-time tracking of physiological changes.

The baseball season is looming. Players and coaches are getting into shape. Maybe they should be dusting off their physics books as well as their catching mitts, reports David Adam.

A genomic barcoding scheme called two-layer DNA seqFISH+ enables the simultaneous mapping of more than 100,000 loci and has been used to identify cell-type-specific subnuclear compartments in the mouse brain.

Measurements of the orbital eccentricities of exoplanets with similar sizes and irradiation as Earth show that these worlds further resemble Earth with near-circular orbits, removing a potential barrier to life.

Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia can proceed normally even in the absence of these cells.

Additive manufacturing can fabricate YBa₂Cu₃O_7-x superconductors with complex shapes, albeit with a polycrystalline microstructure. Here, authors show a route combining the seemingly incompatible steps of 3D-ink extrusion printing and sintering, and single crystal growth.

During the antigen-dependent phase of B cell development, clones expressing high-affinity B cell receptors are transferred from light zones to dark zones of germinal centers, while transforming their energy metabolism. Here authors show that in the light zones, the hypoxic microenvironment promotes growth arrest and apoptosis in B cells, while miR-155 protects the high-affinity clones via inducing a switch in energy utilization.

Head-fixation system is widely used in neuroscience research but has limitations in application due to restraint. Here the authors developed a magnetic voluntary head-fixation system that allows stable rat hippocampal imaging during complex behaviors.

Optimizing approach-avoidance behavior calls for neural encoding of related motivation outcomes. Here, the authors show that behavioral choice under conflict relies on differential neuronal firing patterns after punishment, in which mPFC neurons decode the outcome’s value and MTL neurons follow by reducing subsequent approach.

Instrumental to the migration of antigen-scavenging immune cells, the lymphatic vessel entry receptor LYVE-1 interacts with the hyaluronan glycocalyx, anchored by the leucocyte hyaluronan receptor CD44. Here, dynamic force spectroscopy, crystal structures and MD simulations provide mechanistic insights.