Nature Search

Amino-Acid Sequence of Alpha-Corticotropin

CHOH HAO LI
IRVING I. GESCHWIND
JONATHAN S. DIXON
Research08 Oct 1955
Nature

Volume: 176, P: 687-689
Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways

Castleman disease encompasses a group of disorders characterised by abnormal lymph node morphology. Here the authors use single cell and spatial transcriptomics to assess the stromal, immune and interaction architecture of different subtypes of Castleman disease, indicating potential ligand-receptor interactions between immune cells.

David Smith
Anna Eichinger
Vinodh Pillai
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Dual SORT LNPs for multi-organ base editing

Optimized SORT LNPs enable precise and long-lasting base editing in dual organs in a disease mouse model.

Minjeong Kim
Eunice S. Song
Daniel J. Siegwart
Research02 Jun 2025
Nature Biotechnology

P: 1-9
Genome-wide expression monitoring in Saccharomyces cerevisiae

Lisa Wodicka
Helin Dong
David J. Lockhart
Research01 Dec 1997
Nature Biotechnology

Volume: 15, P: 1359-1367
Expression monitoring by hybridization to high-density oligonucleotide arrays

David J. Lockhart
Helin Dong
Eugene L. Brown
Research01 Dec 1996
Nature Biotechnology

Volume: 14, P: 1675-1680
Difference in Effects of Gibberellins and Auxins on Wall Extensibility of Cucumber Hypocotyls

ROBERT CLELAND
MARGARET L. THOMPSON
WILLIAM K. PURVES
Research03 Aug 1968
Nature

Volume: 219, P: 510-511
Intra- and inter-individual genetic differences in gene expression

Mark Cowley
Chris Cotsapas
Peter Little
ResearchOpen Access15 Apr 2008
Nature Precedings

P: 1
An ancient adaptive episode of convergent molecular evolution confounds phylogenetic inference

Todd Castoe*
A.P. Jason de Koning*
David Pollock
ResearchOpen Access28 Jul 2008
Nature Precedings

P: 1
Isolation of a partial candidate gene for Menkes disease by positional cloning

Julian F. B. Mercer
Janie Livingston
Thomas W. Glover
Research01 Jan 1993
Nature Genetics

Volume: 3, P: 20-25
Genomics, genes, tags, SNPs, drugs and chips

David J. Lockhart
Research01 Nov 1999
Nature Genetics

Volume: 23, P: 10
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

The non-coding RNA RNU4-2, which is highly expressed in the developing human brain, is identified as a syndromic neurodevelopmental disorder gene, and, using RNA sequencing, 5′ splice-site use is shown to be systematically disrupted in individuals with RNU4-2 variants.

Yuyang Chen
Ruebena Dawes
Nicola Whiffin
ResearchOpen Access11 Jul 2024
Nature

Volume: 632, P: 832-840
Persistent and transcriptionally-dependent increase in protein phosphorylation in long-term facilitation ofAplysia sensory neurons

J. David Sweatt
Eric R. Kandel
Research04 May 1989
Nature

Volume: 339, P: 51-54
Myoseverin, a microtubule-binding molecule with novel cellular effects

Gustavo R. Rosania
Young-Tae Chang
Peter G. Schultz
Research01 Mar 2000
Nature Biotechnology

Volume: 18, P: 304-308
Seeds of a universal tree

David Penny
Charles J. O'Kelly
News & Views14 Mar 1991
Nature

Volume: 350, P: 106-107
A CCG expansion in ABCD3 causes oculopharyngodistal myopathy in individuals of European ancestry

A significant proportion of individuals with inherited neuromuscular disease do not receive a genetic diagnosis. Here, the authors establish CCG expansions in the 5’ untranslated region of ABCD3 as a cause of oculopharyngodistal myopathy (OPDM) in individuals of European ancestry and identify increased expression of expansion-containing ABCD3 transcripts as a possible disease mechanism underlying muscle degeneration.

Andrea Cortese
Sarah J. Beecroft
Gianina Ravenscroft
ResearchOpen Access27 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Polar explorations

David D. Hackney
News & Views20 Jul 1995
Nature

Volume: 376, P: 215-216
Genomics, gene expression and DNA arrays

David J. Lockhart
Elizabeth A. Winzeler
Reviews15 Jun 2000
Nature

Volume: 405, P: 827-836
Virus genomes reveal factors that spread and sustained the Ebola epidemic

Frequent dispersal and short-lived local transmission clusters fuelled the 2013–2016 Ebola virus epidemic in Guinea, Liberia and Sierra Leone.

Gytis Dudas
Luiz Max Carvalho
Andrew Rambaut
Research12 Apr 2017
Nature

Volume: 544, P: 309-315
The Chronically Reserpinized Rat as a Possible Model for Cystic Fibrosis. II. Composition and Cilioinhibitory Effects of Submaxillary Saliva

J Ricardo Martinez
Patricia C Adshead
Giulio J Barbero
Research01 May 1975
Pediatric Research

Volume: 9, P: 470-475
An Electron Microscopic Cytochemical Study on Concanavalin A Binding Sites and Their Mobility in Normal and Cystic Fibrosis Fibroblasts In Vitro

Masao Yokoyama
Jeffrey P Change
Sandra L Wilson
Research01 Jun 1977
Pediatric Research

Volume: 11, P: 765-769
Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance

Linda Richards, Paul Lockhart, Christel Depienne and colleagues identify heterozygous DCC mutations in four families and five sporadic individuals with agenesis of the corpus callosum (ACC). They report that DCC mutations result in variable dominant phenotypes with incomplete penetrance, including mirror movements and ACC associated with a favorable developmental prognosis.

Ashley P L Marsh
Delphine Heron
Christel Depienne
Research27 Feb 2017
Nature Genetics

Volume: 49, P: 511-514
Author Correction: A CCG expansion in ABCD3 causes oculopharyngodistal myopathy in individuals of European ancestry

Andrea Cortese
Sarah J. Beecroft
Gianina Ravenscroft
Amendments and CorrectionsOpen Access17 Oct 2024
Nature Communications

Volume: 15, P: 1
Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

For many neurodevelopmental disorder (NDD) risk genes, the significance for mutational burden is unestablished. Here, the authors sequence 125 candidate NDD genes in over 16,000 NDD cases; case-control mutational burden analysis identifies 48 genes with a significant burden of severe ultra-rare mutations.

Tianyun Wang
Kendra Hoekzema
Evan E. Eichler
ResearchOpen Access01 Oct 2020
Nature Communications

Volume: 11, P: 1-13
HER kinase inhibition in patients with HER2- and HER3-mutant cancers

In a basket trial design, the efficacy of the pan-HER kinase inhibitor neratinib is tested in patients with 21 different tumour types, and responses are determined by mutation and tissue type, and are restricted to HER2-mutant cancers.

David M. Hyman
Sarina A. Piha-Paul
David B. Solit
Research31 Jan 2018
Nature

Volume: 554, P: 189-194
A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors

Confining plasma and managing disruptions in tokamak devices is a challenge. Here the authors demonstrate a method predicting and possibly preventing disruptions and macroscopic instabilities in tokamak plasma using data from JET.

Andrea Murari
Riccardo Rossi
Michela Gelfusa
ResearchOpen Access18 Mar 2024
Nature Communications

Volume: 15, P: 1-19
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice

Iiris Hovatta
Richard S. Tennant
Carrolee Barlow
Research23 Oct 2005
Nature

Volume: 438, P: 662-666
Publisher Correction: Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

Mark J. Mulligan
Kirsten E. Lyke
Kathrin U. Jansen
Amendments and Corrections19 Jan 2021
Nature

Volume: 590, P: E26
A major gene for allergy — fact or fancy?

David G. Marsh
Deborah A. Meyers
News & Views01 Dec 1992
Nature Genetics

Volume: 2, P: 252-254
Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases

Evan Eichler and colleagues use single-molecule molecular-inversion probes to sequence the coding and splicing regions of 208 candidate genes in more than 11,730 individuals with neurodevelopmental disorders. They report 91 genes with an excess of de novo or private disruptive mutations, identify 25 genes showing a bias for autism versus intellectual disability, and highlight a network associated with high-functioning autism.

Holly A F Stessman
Bo Xiong
Evan E Eichler
Research13 Feb 2017
Nature Genetics

Volume: 49, P: 515-526
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

S63845 specifically inhibits MCL1 and induces tumour cell death in vitro and in vivo in diverse cancer-derived cell lines with an acceptable safety margin.

András Kotschy
Zoltán Szlavik
Olivier Geneste
Research19 Oct 2016
Nature

Volume: 538, P: 477-482
Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

In a dose-escalation study of the COVID-19 RNA vaccine BNT162b1 in 45 healthy adults, RBD-binding IgG concentrations and SARS-CoV-2 neutralizing titres in sera increased with dose level and after a second vaccine dose.

Mark J. Mulligan
Kirsten E. Lyke
Kathrin U. Jansen
Research12 Aug 2020
Nature

Volume: 586, P: 589-593
A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1

Triazole antifungals are widely used and exert their action by inhibiting ergosterol biosynthesis. Here, Rybak et al show that these drugs both inhibit ergosterol biosynthesis and induce accumulation of pathway intermediates that directly induce inhibition of sterol synthesis.

Jeffrey M. Rybak
Jinhong Xie
Jarrod R. Fortwendel
ResearchOpen Access29 Apr 2024
Nature Communications

Volume: 15, P: 1-16
A small molecule–kinase interaction map for clinical kinase inhibitors

Miles A Fabian
William H Biggs III
David J Lockhart
Research13 Feb 2005
Nature Biotechnology

Volume: 23, P: 329-336
Genetic effects on gene expression across human tissues

Samples of different body regions from hundreds of human donors are used to study how genetic variation influences gene expression levels in 44 disease-relevant tissues.

François Aguet
Andrew A. Brown
Jingchun Zhu
ResearchOpen Access12 Oct 2017
Nature

Volume: 550, P: 204-213
An integrated genomic and transcriptomic survey of mucormycosis-causing fungi

Fungi of the order Mucorales can cause life-threatening infections. Here, Chibucos et al. present genomic and transcriptomic analyses of a diverse set of Mucorales fungi, shedding light on their evolution and identifying potential therapeutic targets in the pathogens and the host.

Marcus C. Chibucos
Sameh Soliman
Vincent M. Bruno
ResearchOpen Access22 Jul 2016
Nature Communications

Volume: 7, P: 1-11
Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance

The fungal pathogen Candida glabrata readily acquires resistance to multiple types of antifungal drugs. Here, Healey et al. show that C. glabrataclinical isolates often carry mutations in a gene involved in DNA mismatch repair, and this is associated with increased propensity to develop antifungal resistance.

Kelley R. Healey
Yanan Zhao
David S. Perlin
ResearchOpen Access29 Mar 2016
Nature Communications

Volume: 7, P: 1-10
Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers

David M. Hyman
Sarina A. Piha-Paul
David B. Solit
Amendments and Corrections12 Feb 2019
Nature

Volume: 566, P: E11-E12
Mastering Atari, Go, chess and shogi by planning with a learned model

A reinforcement-learning algorithm that combines a tree-based search with a learned model achieves superhuman performance in high-performance planning and visually complex domains, without any knowledge of their underlying dynamics.

Julian Schrittwieser
Ioannis Antonoglou
David Silver
Research23 Dec 2020
Nature

Volume: 588, P: 604-609
Quantifying DNA–protein interactions by double-stranded DNA arrays

Martha L. Bulyk
Erik Gentalen
George M. Church
Research01 Jun 1999
Nature Biotechnology

Volume: 17, P: 573-577
Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases

The association between certain mitochondrial DNA variants and increased risk of late-onset diseases in humans could be explained by a direct role of mitochondrial DNA in the regulation of cellular proteostasis.

Na Cai
Aurora Gomez-Duran
Nicole Soranzo
Research23 Aug 2021
Nature Medicine

Volume: 27, P: 1564-1575
Mutant yeast on drugs

David J. Lockhart
News & Views01 Nov 1998
Nature Medicine

Volume: 4, P: 1235-1236
Transcriptional regulation and function during the human cell cycle

Raymond J. Cho
Mingxia Huang
David J. Lockhart
Research01 Jan 2001
Nature Genetics

Volume: 27, P: 48-54
Refining analyses of copy number variation identifies specific genes associated with developmental delay

Evan Eichler and colleagues report an expanded copy number variation (CNV) morbidity map of developmental delay, with additional resequencing of candidate genes in regions implicated by large CNVs. They identify several new disease-associated CNVs and show how their combined approach facilitates discovery of new developmental syndromes and disease genes.

Bradley P Coe
Kali Witherspoon
Evan E Eichler
Research14 Sept 2014
Nature Genetics

Volume: 46, P: 1063-1071
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

Studying patients with long-term diabetes who lack diabetic nephropathy reveals that targeting pyruvate kinase M2 protects against renal disease.

Weier Qi
Hillary A Keenan
George L King
Research24 Apr 2017
Nature Medicine

Volume: 23, P: 753-762
Author Correction: Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

Tianyun Wang
Kendra Hoekzema
Evan E. Eichler
Amendments and CorrectionsOpen Access21 Oct 2020
Nature Communications

Volume: 11, P: 1
Endosymbiotic origin and differential loss of eukaryotic genes

Eukaryotes acquired their prokaryotic genes in two episodes of evolutionary influx corresponding to the origin of mitochondria and plastids, respectively, followed by extensive differential gene loss, uncovering a massive imprint of endosymbiosis in the nuclear genomes of complex cells.

Chuan Ku
Shijulal Nelson-Sathi
William F. Martin
Research19 Aug 2015
Nature

Volume: 524, P: 427-432
RNA expression analysis using a 30 base pair resolution Escherichia coli genome array

Douglas W. Selinger
Kevin J. Cheung
George M. Church
Research01 Dec 2000
Nature Biotechnology

Volume: 18, P: 1262-1268
High density synthetic oligonucleotide arrays

Robert J. Lipshutz
Stephen P.A. Fodor
David J. Lockhart
Reviews01 Jan 1999
Nature Genetics

Volume: 21, P: 20-24
Mutations in SH3PXD2B cause Borrone dermato-cardio-skeletal syndrome

Gabrielle R Wilson
Jasmine Sunley
Paul J Lockhart
Research09 Oct 2013
European Journal of Human Genetics

Volume: 22, P: 741-747

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