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Showing 51–85 of 85 results

Advanced filters: Author: David MacPherson Clear advanced filters

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

The FANTOM4 study identified transcriptional start sites active during proliferation arrest and differentiation of the human monocytic cell line THP-1. Systematic knockdown of 52 transcription factors provide support for their model in which a complex transcriptional network regulates the differentiation process.

Harukazu Suzuki
Alistair R R Forrest
Yoshihide Hayashizaki
Research19 Apr 2009
Nature Genetics

Volume: 41, P: 553-562
Does the ocean–atmosphere system have more than one stable mode of operation?

Wallace S. Broecker
Dorothy M. Peteet
David Rind
Reviews02 May 1985
Nature

Volume: 315, P: 21-26
The retinoblastoma tumor-suppressor gene, the exception that proves the rule

D W Goodrich
Reviews28 Aug 2006
Oncogene

Volume: 25, P: 5233-5243
Proof of principle for epitope-focused vaccine design

Computational protein design methods are used to generate new candidates for a human respiratory syncytial virus (RSV) vaccine; artificial protein scaffolds that mimic the structure of a RSV epitope are shown to induce RSV-specific neutralizing antibodies in macaques.

Bruno E. Correia
John T. Bates
William R. Schief
Research05 Feb 2014
Nature

Volume: 507, P: 201-206
Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

The secretome from cancer and stromal cells contributes to the creation of a microenvironment, which in turn contributes to invasion and angiogenesis. Here, the authors compare the secretomes of immortalized normal fibroblasts and cancer-derived fibroblast and identify CLIC3 as a driver of cancer progression.

Juan R. Hernandez-Fernaud
Elena Ruengeler
Sara Zanivan
ResearchOpen Access15 Feb 2017
Nature Communications

Volume: 8, P: 1-17
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribution to VEO-IBD and characterize a rare somatic mosaic VEO-IBD patient.

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
ResearchOpen Access21 Feb 2020
Nature Communications

Volume: 11, P: 1-15
p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism

p53 inactivation is nearly universal in small-cell lung cancer (SCLC), but its tumor suppressive role in this cancer type is poorly understood. Here the authors show that intertumoral heterogeneity in SCLC influences the biological mechanisms of p53-mediated tumor suppression and identify a role for cyclophilins in p53-dependent necrotic cell death.

Jonuelle Acosta
Qinglan Li
David M. Feldser
ResearchOpen Access21 Jul 2023
Nature Communications

Volume: 14, P: 1-18
Functional interdependence of BRD4 and DOT1L in MLL leukemia

The histone methyltransferase DOT1L and the chromatin reader BRD4 together facilitate transcription of genes critical to the molecular pathogenesis of MLL leukemia.

Omer Gilan
Enid Y N Lam
Mark A Dawson
Research13 Jun 2016
Nature Structural & Molecular Biology

Volume: 23, P: 673-681
Zeb2 drives invasive and microbiota-dependent colon carcinoma

Van Loo and colleagues report that loss of the Zeb2 regulator of epithelial-to-mesenchymal transition from the intestinal epithelium leads to inflammation, increased intestinal permeability and colorectal cancer development, which is enhanced by the resident intestinal microbiome.

Karolina Slowicka
Ioanna Petta
Geert van Loo
Research15 Jun 2020
Nature Cancer

Volume: 1, P: 620-634
MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG

High intracellular concentrations of the α-ketoglutarate analog N-oxalylglycine, owing to MCT2-mediated transport of its newly described prodrug MOG, inhibit multiple enzymes in glutamine metabolism and selectively kill MCT2-expressing cancer cells.

Louise Fets
Paul C. Driscoll
Dimitrios Anastasiou
Research08 Oct 2018
Nature Chemical Biology

Volume: 14, P: 1032-1042
Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype

The molecular mechanisms underlying the effects of beta2-integrins on signalling in immune cells are unclear. Here the authors show that disruption of the interaction between beta2-integrins and kindlin-3 results in increased GM-CSF receptor signalling, affecting dendritic cell activation and migration and Th1 immunity.

Vicky Louise Morrison
Martyn John James
Susanna Carola Fagerholm
Research28 Oct 2014
Nature Communications

Volume: 5, P: 1-13
The language of chromatin modification in human cancers

Deregulation of chromatin modification underlies a myriad of oncogenic processes. This Review synthesizes the many connections between chromatin modifications and cancer, discussing recent advances and highlighting options for therapeutic targeting.

Shuai Zhao
C. David Allis
Gang Greg Wang
Reviews17 May 2021
Nature Reviews Cancer

Volume: 21, P: 413-430
Global Roadkill Data: a dataset on terrestrial vertebrate mortality caused by collision with vehicles

Clara Grilo
Tomé Neves
Eric Guinard
ResearchOpen Access31 Mar 2025
Scientific Data

Volume: 12, P: 1-14
Network controllability analysis of intracellular signalling reveals viruses are actively controlling molecular systems

Vandana Ravindran
Jose C. Nacher
David L. Robertson
ResearchOpen Access14 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
Amendments and CorrectionsOpen Access22 Jun 2022
Nature Communications

Volume: 13, P: 1
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections16 Mar 2018
Nature Genetics

Volume: 50, P: 766-767
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections16 Mar 2018
Nature Genetics

Volume: 50, P: 765-766
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections03 Jun 2019
Nature Genetics

Volume: 51, P: 1191-1192
A common coding variant in CASP8 is associated with breast cancer risk

Angela Cox
Alison M Dunning
Douglas F Easton
Research11 Feb 2007
Nature Genetics

Volume: 39, P: 352-358
Independent validation of the PREDICT breast cancer prognosis prediction tool in 45,789 patients using Scottish Cancer Registry data

Ewan Gray
Joachim Marti
Peter S. Hall
ResearchOpen Access17 Sept 2018
British Journal of Cancer

Volume: 119, P: 808-814
AGG interruptions within the maternal FMR1 gene reduce the risk of offspring with fragile X syndrome

Carolyn M. Yrigollen
Blythe Durbin-Johnson
Flora Tassone
Research12 Apr 2012
Genetics in Medicine

Volume: 14, P: 729-736
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

This Opinion, written by many leading experts in small cell lung cancer (SCLC) research, proposes a new model of SCLC subtypes defined by differential expression of four key transcription regulators. Such classification should help to focus and accelerate therapeutic research.

Charles M. Rudin
John T. Poirier
Adi F. Gazdar
Reviews29 Mar 2019
Nature Reviews Cancer

Volume: 19, P: 289-297
Pocket proteins and cell cycle control

David Cobrinik
Reviews18 Apr 2005
Oncogene

Volume: 24, P: 2796-2809
Circulating tumour mutation detection in triple-negative breast cancer as an adjunct to tissue response assessment

Elena Zaikova
Brian Y. C. Cheng
Karen Gelmon
ResearchOpen Access05 Jan 2024
npj Breast Cancer

Volume: 10, P: 1-9
Preparation and validation of the first WHO international genetic reference panel for Fragile X syndrome

Malcolm Hawkins
Jennifer Boyle
J Ross Hawkins
Research25 Aug 2010
European Journal of Human Genetics

Volume: 19, P: 10-17
Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis

David Berry
Clarissa Schwab
Alexander Loy
Research10 May 2012
The ISME Journal

Volume: 6, P: 2091-2106
Effects of sampling effort on biodiversity patterns estimated from environmental DNA metabarcoding surveys

Erin K. Grey
Louis Bernatchez
David M. Lodge
ResearchOpen Access11 Jun 2018
Scientific Reports

Volume: 8, P: 1-10
Cell death attenuation by `Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

Dita M Rasper
John P Vaillancourt
Donald W Nicholson
Research07 Apr 1998
Cell Death & Differentiation

Volume: 5, P: 271-288
ISL1 is a major susceptibility gene for classic bladder exstrophy and a regulator of urinary tract development

Rong Zhang
Michael Knapp
Heiko Reutter
ResearchOpen Access08 Feb 2017
Scientific Reports

Volume: 7, P: 1-8
Targeting membrane proteins for antibody discovery using phage display

Martina L. Jones
Mohamed A. Alfaleh
Stephen M. Mahler
ResearchOpen Access18 May 2016
Scientific Reports

Volume: 6, P: 1-11
A review of late-stage CNS drug candidates for the treatment of obesity

D J Heal
J Gosden
S L Smith
Reviews13 Mar 2012
International Journal of Obesity

Volume: 37, P: 107-117
NRG1 gene rearrangements in clinical breast cancer: identification of an adjacent novel amplicon associated with poor prognosis

Leah M Prentice
Ashleen Shadeo
David G Huntsman
Research18 Jul 2005
Oncogene

Volume: 24, P: 7281-7289
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Jason Flannick
Christian Fuchsberger
Mark I. McCarthy
ResearchOpen Access19 Dec 2017
Scientific Data

Volume: 4, P: 1-22
Genetically-engineered mouse models of small cell lung cancer: the next generation

Matthew G. Oser
David MacPherson
Kwon-Sik Park
Reviews08 Jan 2024
Oncogene

Volume: 43, P: 457-469
Systematic overview of systematic reviews and clinical guidelines: assessment and prevention of behavioural risk factors associated with oral cancer to inform dental professionals in primary care dental practices

Sweta Mathur
David I. Conway
Alastair J. Ross
Reviews07 Mar 2022
Evidence-Based Dentistry

P: 1-10

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