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Showing 1–50 of 6209 results

Advanced filters: Author: David Smith Clear advanced filters

Mosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti

Infection of mosquito immune cells by dengue and Zika virus enhances the spread of virus infection to mosquito tissues, such as the salivary glands, to promote virus transmission and highlights conserved roles of immune cells in virus dissemination.

David R. Hall
Rebecca M. Johnson
Ryan C. Smith
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Xian-Le Bu
Wei Zhu
Kristin Fargher
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Native diversity buffers against severity of non-native tree invasions

Analysis combining multiple global tree databases reveals that whether a ___location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Camille S. Delavaux
Thomas W. Crowther
Daniel S. Maynard
ResearchOpen Access23 Aug 2023
Nature

Volume: 621, P: 773-781
Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways

Castleman disease encompasses a group of disorders characterised by abnormal lymph node morphology. Here the authors use single cell and spatial transcriptomics to assess the stromal, immune and interaction architecture of different subtypes of Castleman disease, indicating potential ligand-receptor interactions between immune cells.

David Smith
Anna Eichinger
Vinodh Pillai
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Potential impact and cost-effectiveness of long-acting injectable lenacapavir plus cabotegravir as HIV treatment in Africa

Long-acting injectable drugs for viral suppression of HIV are not yet available in African settings. Here, the authors present a mathematical modelling and cost effectiveness study of a long-acting drug combination in adults living with HIV in East, Central, Southern and West Africa.

Andrew Phillips
Jennifer Smith
Paul Revill
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-13
The global seafood trade, embodied nutrients, and nutritional affordability

Despite exporting nutrient-rich seafood, developing countries import seafood with higher nutrient density per dollar than developed nations. These nutritional bargains are linked to differences in processing and product forms of traded seafood.

Yaqin Liu
Martin D. Smith
Tsugumi Yamashita
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
A high mutual inclination system around KOI-134 revealed by transit timing variations

Using Kepler, this study identifies a compact multiplanetary system that is not flat, where gravitational interactions cause its planets’ periods to change by nearly a day per cycle and their orbital planes to tilt back and forth.

Emma Nabbie
Chelsea X. Huang
George Zhou
Research27 Jun 2025
Nature Astronomy

P: 1-9
Fine-mapping genomic loci refines bipolar disorder risk genes

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Maria Koromina
Ashvin Ravi
Niamh Mullins
ResearchOpen Access25 Jun 2025
Nature Neuroscience

P: 1-11
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Jie Shen
Wander Valentim
Gita A. Pathak
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Immune impacts of fire smoke exposure

Methylation and mass cytometry investigations demonstrate the consequences of smoke exposure in humans at the single-cell level.

Mary M. Johnson
Abhinav Kaushik
Kari C. Nadeau
Research26 Jun 2025
Nature Medicine

P: 1-11
The long-term effects of chemotherapy on normal blood cells

Mutational signature analysis of blood cells isolated from 23 chemotherapy-exposed samples and 9 nonexposed controls characterizes the effects of various drugs on mutational burden, signature exposure and cell types.

Emily Mitchell
My H. Pham
Michael R. Stratton
ResearchOpen Access01 Jul 2025
Nature Genetics

P: 1-11
Coesite in clinopyroxene in the Caledonides and its implications for geodynamics

David C. Smith
Research23 Aug 1984
Nature

Volume: 310, P: 641-644
Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication

Bacterial attachment on implanted medical devices depends on surface topography. Here, the authors screen combinatorially generated shapes embossed into polymers to investigate topographical control of bacterial responses to surfaces.

Manuel Romero
Jeni Luckett
Paul Williams
ResearchOpen Access18 Jun 2025
Nature Communications

Volume: 16, P: 1-18
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism

Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) that use phosphorylation in their reaction mechanisms.

Edrees H. Rashan
Abigail K. Bartlett
David J. Pagliarini
ResearchOpen Access19 Jun 2025
Nature Structural & Molecular Biology

P: 1-11
Tegavivint triggers TECR-dependent nonapoptotic cancer cell death

In chemical-genetic and lipidomics analyses, the clinical candidate oncology drug tegavivint induced an unconventional form of nonapoptotic cell death that required the lipid metabolic enzyme trans-2,3-enoyl-CoA reductase.

Logan Leak
Ziwei Wang
Scott J. Dixon
Research26 May 2025
Nature Chemical Biology

P: 1-12
National secular trends in intelligence and education: a twenty-year cross-sectional study

Some surveys of intelligence have suggested that the mean IQ is rising; others, that it is decreasing alarmingly. The explanation seems to be that the educational level of the populations has changed.

T. W. Teasdale
David R. Owen
Comments & Opinion08 Jan 1987
Nature

Volume: 325, P: 119-121
Sequence diversity lost in early pregnancy

Around 1 in 136 pregnancies is lost due to a pathogenic small sequence variant genotype in the fetus.

Gudny A. Arnadottir
Hakon Jonsson
Kari Stefansson
ResearchOpen Access21 May 2025
Nature

Volume: 642, P: 672-681
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
The global spectrum of tree crown architecture

Trees come in all shapes and size, but what drives this incredible variation in tree form remains poorly understood. Using a global dataset, the authors show that a combination of climate, competition, disturbance and evolutionary history shape the crown architecture of the world’s trees and thereby constrain the 3D structure of woody ecosystems.

Tommaso Jucker
Fabian Jörg Fischer
Niklaus E. Zimmermann
ResearchOpen Access26 May 2025
Nature Communications

Volume: 16, P: 1-16
Genome-wide association study of long COVID

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Vilma Lammi
Tomoko Nakanishi
Hanna M. Ollila
ResearchOpen Access21 May 2025
Nature Genetics

Volume: 57, P: 1402-1417
Lutetium-177–PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial

In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [¹⁷⁷Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [¹⁷⁷Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

Edmond M. Kwan
Sarah W. S. Ng
Alison Y. Zhang
Research27 May 2025
Nature Medicine

P: 1-15
Neutron scattering and thermodynamic evidence for emergent photons and fractionalization in a pyrochlore spin ice

Quantum spin-ice phases are predicted to have emergent gauge fields and fractionalization. Neutron scattering and thermodynamic measurements of the quantum spin-ice candidate Ce₂Zr₂O₇ show features consistent with these predictions.

Bin Gao
Félix Desrochers
Pengcheng Dai
Research19 Jun 2025
Nature Physics

P: 1-8
Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

P: 1
Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

P: 1
Gabapentinoids confer survival benefit in human glioblastoma

In preclinical studies, the FDA approved TSP-1 antagonist gabapentin has been shown to disrupt neuronal-glioma interactions, slowing glioblastoma progression. Here, authors report a retrospective cohort study demonstrating a survival benefit associated with gabapentin in patients with newly diagnosed glioblastoma.

Joshua D. Bernstock
Mulki Mehari
Shawn L. Hervey-Jumper
ResearchOpen Access15 May 2025
Nature Communications

Volume: 16, P: 1-6
Using co-sharing to identify use of mainstream news for promoting potentially misleading narratives

Goel et al. examine why some factually correct news articles are often shared by users who also shared fake news articles on social media.

Pranav Goel
Jon Green
Philip S. Resnik
Research10 Jun 2025
Nature Human Behaviour

P: 1-18
Interview: David King

Former chief science advisor to the UK government David King once said that last month's talks in Copenhagen would be the “last chance saloon” for tackling climate change. But there is hope beyond Copenhagen, says King. Olive Heffernan reports.

Olive Heffernan
David King
Comments & Opinion21 Jan 2010
Nature Climate Change

Volume: 1, P: 22
Factor Dependent Binding of Methionyl-tRNAs to Reticulocyte Ribosomes

DAVID A. SHAFRITZ
W. FRENCH ANDERSON
Research29 Aug 1970
Nature

Volume: 227, P: 918-920
Interaction of small and extended defects in nonstoichiometric oxides

L. A. Bursill
David J. Smith
Research24 May 1984
Nature

Volume: 309, P: 319-321
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Xihao Li
Han Chen
Xihong Lin
Research07 Feb 2025
Nature Computational Science

Volume: 5, P: 125-143
Multiple self–healing squamous epitheliomata (ESS1) mapped to chromosome 9q22–q31 in families with common ancestry

David R. Goudie
Martin A.R. Yuille
Malcolm A. Ferguson-Smith
Research01 Feb 1993
Nature Genetics

Volume: 3, P: 165-169
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Dynamic observation of defect annealing in CdTe at lattice resolution

R. Sinclair
F. A. Ponce
C. J. D. Catto
Research08 Jul 1982
Nature

Volume: 298, P: 127-131
Opportunities and challenges for monitoring terrestrial biodiversity in the robotics age

An expert-elicitation process identifies current methodological barriers for monitoring terrestrial biodiversity, and how technological and procedural development of robotic and autonomous systems may contribute to overcoming these challenges.

Stephen Pringle
Martin Dallimer
Zoe G. Davies
ResearchOpen Access22 May 2025
Nature Ecology & Evolution

Volume: 9, P: 1031-1042
In retrospect chosen by David Jones

David Jones
Books & Arts18 Jun 1998
Nature

Volume: 393, P: 642
Skull morphology analysis suggests the extinct Cape lion, Panthera leo melanochaita (Smith, 1842), is not distinctive

Olga Nanova
David M. Cooper
Nobuyuki Yamaguchi
ResearchOpen Access16 Oct 2024
Scientific Reports

Volume: 14, P: 1-12
The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour

A distinct population of CD4 T cells resides in specific regions of the steady-state brain, and these T cells are programmed in the periphery by the microbiome to coordinate adaptive behaviour.

Tomomi M. Yoshida
Mytien Nguyen
Andrew Wang
Research28 May 2025
Nature

P: 1-10
Advancing cancer research via comparative oncology

Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular and cellular mechanisms underlying the remarkable cancer resistance of some taxa. Therefore, this Perspective by Vincze et al. calls for the increased use of non-conventional model organisms in cancer research to advance cancer prevention and treatment strategies.

Orsolya Vincze
Benjamin Spada
Thomas Pradeu
Reviews27 Jun 2025
Nature Reviews Cancer

P: 1-9
Third track model for coordination of septal peptidoglycan synthesis and degradation by FtsN in Escherichia coli

Partitioning of FtsN and the septal peptidoglycan synthesis complex between an active synthesis track and an inactive denuded glycan track coordinates opposing peptidoglycan synthesis and degradation activities in E. coli.

Zhixin Lyu
Xinxing Yang
Jie Xiao
Research27 May 2025
Nature Microbiology

Volume: 10, P: 1521-1534
Suggested actions from the Melbourne HVP Information Seminar

Richard Cotton
Myles Axton
Ingrid Winship
ResearchOpen Access11 Apr 2008
Nature Precedings

P: 1
Exploiting evolution to treat drug resistance: Combination therapy and the double bind

David Basanta
Robert Gatenby
Alexander Anderson
ResearchOpen Access12 Sept 2011
Nature Precedings

P: 1
Suggested actions from the Melbourne HVP Information Seminar

Richard Cotton
Myles Axton
Ingrid Winship
ResearchOpen Access09 Apr 2008
Nature Precedings

P: 1
A multimodal vision foundation model for clinical dermatology

Trained on large and multicenter datasets with different imaging modalities, a foundation model is shown to have strong performance on the full spectrum of clinically relevant tasks and to increase user accuracy in diagnostic tasks.

Siyuan Yan
Zhen Yu
Zongyuan Ge
ResearchOpen Access06 Jun 2025
Nature Medicine

P: 1-12
National Academies report has broad support

Paul Vincelli
Douglas Jackson-Smith
Susan Weller
Correspondence11 Apr 2017
Nature Biotechnology

Volume: 35, P: 304-306
Cultural innovations were boosted under the pressure of epidemic outbreaks in European History

David D. Zhang
Qing Pei
Mengyuan Qiu
ResearchOpen Access01 Jul 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-8
First Voyager view of the rings of Saturn

Stewart A. Collins
Allan F. Cook II
Richard J. Terrile
Research04 Dec 1980
Nature

Volume: 288, P: 439-442
Simplified Technique for Isolation of Sub-Cellular Particles

DAVID W. E. SMITH
Research21 Oct 1961
Nature

Volume: 192, P: 234-235
Genomic landscape of diffuse glioma revealed by whole genome sequencing

The genomic landscape of diffuse gliomas remains to be characterised. Here, the authors perform whole genome sequencing of 403 tumours and identify recurrent coding and non-coding genetic mutations, their associations with clinical outcomes and potential therapeutic targets.

Ben Kinnersley
Josephine Jung
Keyoumars Ashkan
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-18

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