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Showing 1–7 of 7 results
Advanced filters: Author: Dohyun Im Clear advanced filters

  • VMAT2 regulates neurotransmitter uptake into synaptic vesicles. Here, the authors determined the cryo-EM structures of VMAT2, providing a structural basis for understanding VMAT2- mediated vesicular transport of neurotransmitters.

    • Dohyun Im
    • Mika Jormakka
    • So Iwata
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Small-conductance Ca2+ -activated K+ (KCa2.1-KCa2.3) channels modulate neuronal and cardiac excitability. Here, authors report cryo-EM structures of the KCa2.2 channel, providing a basis for understanding the small unitary conductance and pharmacology of KCa2.x channels.

    • Young-Woo Nam
    • Dohyun Im
    • Miao Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • This study reveals how anamorelin, a superagonist targeting the ghrelin receptor, works compared to other drugs. Structural insights into ligand binding and genetic variations offer a framework for personalized therapies

    • Yuki Shiimura
    • Dohyun Im
    • Ikuo Masuho
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 531-542

  • Histamine receptor H4R is implicated in chronic inflammatory diseases, such as asthma, arthritis, and atopic dermatitis. Here, the authors determined the first cryo-EM structure of the histamine H4 receptor, providing valuable structural insights for the design of drugs targeting H4R in chronic inflammatory diseases.

    • Dohyun Im
    • Jun-ichi Kishikawa
    • So Iwata
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Shifts in temperature alter the structure and dynamics of macromolecules. Now, infra-red laser-induced temperature jump is combined with X-ray crystallography to observe protein structural dynamics in real time. Using this method, motions related to the catalytic cycle of lysozyme, a model enzyme, are visualized at atomic resolution and across broad timescales.

    • Alexander M. Wolff
    • Eriko Nango
    • Michael C. Thompson
    ResearchOpen Access
    Nature Chemistry
    Volume: 15, P: 1549-1558

  • The dopamine D2 receptor (D2R) is a GPCR and an important drug target for schizophrenia treatment. Here, the authors present the crystal structure of human D2R in complex with the antipsychotic drug spiperone, which is of interest for designing antipsychotics with improved receptor selectivity.

    • Dohyun Im
    • Asuka Inoue
    • Tatsuro Shimamura
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11