Nature Search

Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis

Mammals respond to bacterial infection by inducing the expression of hepcidin, which restricts serum iron levels through its effects on macrophage iron export and thereby limits systemic bacterial growth. Kim et al. now report that the macrophage-tropic pathogen Salmonella typhimurium exploits this pathway by triggering the expression of estrogen-related receptor-γ (ERR-γ), which they show increases hepcidin expression and enhances S. typhimurium growth.

Don-Kyu Kim
Jae-Ho Jeong
Hueng-Sik Choi
Research23 Mar 2014
Nature Medicine

Volume: 20, P: 419-424
Reduction in limb-movement complexity at term-equivalent age is associated with motor developmental delay in very-preterm or very-low-birth-weight infants

Myung Woo Park
Hyung-Ik Shin
Woo Hyung Lee
ResearchOpen Access10 Apr 2024
Scientific Reports

Volume: 14, P: 1-8
The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors

The orphan nuclear receptor SHP is a transcriptional corepressor in the liver. Jo and colleagues show that it also acts to negatively regulate Toll-like receptor signaling at multiple levels.

Jae-Min Yuk
Dong-Min Shin
Eun-Kyeong Jo
Research03 Jul 2011
Nature Immunology

Volume: 12, P: 742-751
Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression

Don-Kyu Kim
Yong-Hoon Kim
Hueng-Sik Choi
ResearchOpen Access30 Sept 2016
Scientific Reports

Volume: 6, P: 1-11
Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes

The pathogenesis of osteoarthritis is unclear. The authors show that estrogen-related receptor gamma is upregulated in cartilage from patients and mouse models, where it drives production of matrix-degrading MMPs in chondrocytes, and that its downregulation ameliorates pathology in mice.

Young-Ok Son
Seulki Park
Jang-Soo Chun
ResearchOpen Access15 Dec 2017
Nature Communications

Volume: 8, P: 1-11
Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation

Jung-Ran Noh
Yong-Hoon Kim
Chul-Ho Lee
ResearchOpen Access15 Oct 2018
Scientific Reports

Volume: 8, P: 1-11
Impact of mild traumatic brain injury on health behaviors

Yookyung Lee
Yoonjeong Choi
Byung-Mo Oh
ResearchOpen Access10 Jan 2025
Scientific Reports

Volume: 15, P: 1-11
Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus

Yeong-Bin Baek
Hyung-Jun Kwon
Kyoung-Oh Cho
ResearchOpen Access17 Oct 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-12
Deep learning-based quantitative analyses of spontaneous movements and their association with early neurological development in preterm infants

Hyun Iee Shin
Hyung-Ik Shin
Woo Hyung Lee
ResearchOpen Access24 Feb 2022
Scientific Reports

Volume: 12, P: 1-9
Strong association of type 2 diabetes with degenerative lumbar spine disorders

Chul-Hyun Park
Kyoung-Bok Min
Don-Kyu Kim
ResearchOpen Access13 Aug 2021
Scientific Reports

Volume: 11, P: 1-11
Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression

Yong-Soo Lee
Yong-Hoon Kim
Hueng-Sik Choi
ResearchOpen Access08 Dec 2017
Experimental & Molecular Medicine

Volume: 49, P: e408

Search

Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis

Reduction in limb-movement complexity at term-equivalent age is associated with motor developmental delay in very-preterm or very-low-birth-weight infants

The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors

Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression

Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes

Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation

Impact of mild traumatic brain injury on health behaviors

Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus

Deep learning-based quantitative analyses of spontaneous movements and their association with early neurological development in preterm infants

Strong association of type 2 diabetes with degenerative lumbar spine disorders

Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression

Search

Quick links

Search

Filter By:

Search

Quick links