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Tree cover gains in the moist tropics (1982–2015) were 56% naturally regenerated forests and 27% managed tree systems, with forest type influencing carbon recovery. Effective forest restoration requires robust tracking of forest types established by restoration efforts.

Researchers employ machine learning-driven simulations to investigate the behavior of oxygen under extreme pressures up to 1,000 TPa. They identify stable phases and obtain information on the melting line and thermal properties of oxygen, improving our understanding of the structure and evolution of white dwarfs.

Proton transfer plays a key role in nature, yet its ultrafast dynamics remain elusive. Here the authors use coincidence spectroscopy and theoretical simulations to show that radiolytic doubly-ionized pyrrole triggers proton transfer to water within 60 fs.

Effective delivery of therapeutic agents to the infection site and the modulation of the immunosuppressive microenvironment at the site of infection are vital for the treatment of chronic bacterial infections but remain elusive. Here, the authors address these issues by developing a nanomedicine that combines chemical and immunological therapies for chronic bacterial infection management.

Endothelial injury drives vascular diseases like atherosclerosis, but key regulators are unclear. Here, the authors show that endothelial major vault protein (MVP) acts as an intracellular regulator promoting Parkin-mediated mitophagy, thereby antagonizing vascular remodeling and suggesting its role as a potential therapeutic target.

The active site of a solid catalyst depends strongly on the specific reaction. Here, the authors reveal distinct active sites for CO₂ and CO hydrogenation to methanol over ZnO-ZrO₂, using experimental surface kinetics, structural characterization, and theoretical modeling.

A template-free magnetization strategy for inverse programming of hard-magnetic domains embedded in solvent-responsive hydrogel is reported using a photodosage-based printing method, achieving shape morphing into 3D curved surfaces under the actuation of a magnetic field.

The authors introduce an exciting paradigm for achieving perfect anomalous refraction using an all-dielectric quasi–three-dimensional subwavelength structure and demonstrate half-space beam scanning.

This study shows that climate change has caused more frequent land-ocean transboundary migrations of warm-season heatwaves, especially in the tropics, driven by stronger landward winds and increased land-ocean temperature gradient.

Semi-aquatic robots rely on surface tension for propulsion, which implies that breaking the water surface is a limitation. Here, the authors developed a soft robot with a superhydrophobic body, achieving high jumping height and take-off velocity.

The suboptimal performance of perovskite solar cells based on non-fullerene acceptor as the electron-transporting layer underscores the need for their molecular engineering. Here, authors substitute the core of Y6 with phenanthroline and crown ether, achieving a certified efficiency of 25.59%.

A telomere-to-telomere genome assembly of allohexaploid bread wheat cv. Chinese Spring (CS-IAAS), along with transcriptomic and proteomic data, highlights wheat genome complexity and its structural and functional features.

Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Here, Zhang et al. succeed in creating a heavily distorted oxygen deficient film of lanthanum cobaltite. The new phase of LaCoO_2.5 has several unique properties, most notably, a Curie temperature of 284 K, significantly larger than the films from which it was derived.

In this work, the authors report that citronellal stimulates skin renewal by promoting keratinocyte proliferation through the activation of TRPV3. Structural and functional analysis elucidate that essential oil ligands activate TRPV3 channels by competitively displacing endogenous lipids from the vanilloid site. These findings can help move skin healthcare forward.

High-speed electrostatic micromotors with low energy consumption are attractive for small-scale electromechanical systems, but applications are limited by power supplies. Here the authors use a triboelectric nanogenerator for actuation of a high-speed micromotor by low-frequency mechanical stimuli.

Prussian blue has been used as a photothermal agent for cancer therapy. Here the authors describe the production of Prussian blue nanoparticles from S. oneidensis MR-1 bacteria and show that a Prussian blue-based mitochondria-targeting nanoplatform potentiates response to immune checkpoint blockade.

Fabricating high-performance cellulose fibres is desirable for the development of sustainable materials, but remains challenging. Here the authors report a draw spinning/de-acetylation method to fabricate cellulose fibres that exhibit mechanical strength exceeding that of existing fibre materials.

Macrophage TP53-induced glycolysis and apoptosis regulator (TIGAR) is implicated in a range of immunopathology. Here the authors show TIGAR drives inflammation and sepsis via activation of TAK1 and that disruption of TIGAR-TAK1 interaction in a murine model of sepsis reduces immunopathology.

The authors show that SARS-CoV-2-specific T cells in the lung are key to fighting infection and persist after viral clearance, contributing to long-term immunity and protection.

Γ and K valleys in twisted transition metal dichalcogenides have emerged as highly tunable knobs for accessing different correlated electronic states in solid-state devices. Here, the authors tune a Mott-Hubbard state to a charge-transfer insulator state in twisted double-bilayer WSe₂.

In the phase 3 EVER-132-002 trial, patients with HR⁺HER2⁻ metastatic breast cancer from Asia were treated with the Trop-2-directed antibody–drug conjugate sacituzumab govitecan or chemotherapy, and those receiving sacituzumab govitecan experienced prolonged progression-free survival compared with patients treated with chemotherapy.

Base editors lacking a deaminase improve thymine and cytosine conversion.

Here the authors reveal that phase‐separated nuclear CCER1 condensates are required for male fertility by mediating chromatin condensation and histone epigenetic modification, while loss‐of‐function variants of human CCER1 are pathogenic in patients with nonobstructive azoospermia (NOA).

A RuNi/NC catalyst with optimized interfacial water dynamics for alkaline H₂ evolution is reported. The designed strategy shows enhanced catalytic activity by achieving 12 mV overpotential at 10 mA cm^‒2 and 13.6-fold higher mass activity than Pt/C.

Artificial photosynthesis of urea from NH₃ and CO₂ remains difficult to achieve. Herein, by three altering the number of heterocyclic N atoms within a series of covalent organic frameworks, the authors report an increase in urea photosynthesis yields and efficiencies.

The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.

The stability and efficiency of thermally activated delayed fluorescent (TADF) emitters are still limited. Here the authors design TADF compounds by introducing an auxiliary acceptor with both enhanced stability and enhanced efficiency.

Previous studies of exciton condensates in moire heterostructures have been limited to large layer separation or one carrier type. Here the authors report a complete sequence of exciton condensates at both electron and hole fillings in large-angle twisted double bilayer graphene without a spacer layer.

Base editing technology has great potential in treating pathogenic single-nucleotide variations. Using a dual-AAV base editing system, Wu et al. restored visual functions in a mouse model of retinitis pigmentosa.

The hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.

Magnetic random access memory (MRAM) exhibits remarkable device endurance, while also offering potential operation speed and energy efficiency improvements compared to conventional random access memory. However, challenges remain, both in terms of efficiency, and miniaturization. Here, Wang et al demonstrate a van der Waals (vdW) based spin-orbit torque switching, in a Fe₃GeTe₂/Bi2Te₃ heterostructure, paving the way for thinner and higher efficiency spin-orbit torque based vdW MRAM.

Aurora-A kinase is frequently over-expressed in tumours. Here, the authors show that it modulates the activity of lactate dehydrogenase B, resulting in enhanced glycolysis, bio-synthesis and tumour growth.

Metabolic diseases are associated with chronic, low-grade inflammation. Here the authors show that major vault protein (MVP) suppresses NF-κB signalling in macrophages via an IRAK1–TRAF6 axis and that loss of MVP in myeloid cells exacerbates the inflammatory response in mice fed a high fat diet.

Developing highly active and stable oxygen evolution electrocatalysts is crucial for enabling large-scale hydrogen production from seawater. Here, authors report a robust O₂-producing electrode for alkaline seawater, highlighting the critical role of distributed sites near the catalytic sites.

Varying growth temperatures enables the tuning of the degree of disorder, which is fully described by the absence/presence of medium-range order and temperature-dependent densities of nanocrystallites, and electrical conductivity in amorphous monolayer carbon films.

Innate lymphoid cells (ILC) have been shown to be involved in a range of inflammatory contexts but how their cellular lineage is regulated is not fully established. Here the authors show a role for circular RNA circTmem241 in the differentiation of ILC3 via initiation of Elk3 transcription.

The toxicity arising from generalised stimulation of T cells restricts applicability of CD137 agonists in cancer immune therapy. Here authors show that a bispecific antibody blocking PD-1 while activating CD137 efficiently restricts T cell activation to the tumour microenvironment, resulting in efficient tumour control and reduced liver toxicity.