Nature Search

The past 10 years—new hormones, new functions, new endocrine organs

In this Viewpoint, six members of our Advisory Board comment on advances in the past 10 years that have revealed new hormones, new functions for known hormones and endocrine organs and new endocrine roles for well-known organs. The authors discuss how bone was recognized as an endocrine organ, the emerging understanding of the importance of gut hormones, targeting ectopic adipose tissue and the pathogenesis and treatment of type 2 diabetes mellitus.

Roger Bouillon
Daniel J. Drucker
Paul Zimmet
Reviews01 Sept 2015
Nature Reviews Endocrinology

Volume: 11, P: 681-686
Keep an eye on diabetes

Ele Ferrannini
Editorial01 Dec 2006
Nature Clinical Practice Endocrinology & Metabolism

Volume: 2, P: 649
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Both rare and common variants contribute to the aetiology of complex traits such as type 2 diabetes (T2D). Here, the authors examine the effect of coding variation on glycaemic traits and T2D, and identify low-frequency variation in GLP1Rsignificantly associated with these traits.

Jennifer Wessel
Audrey Y Chu
Mark O Goodarzi
ResearchOpen Access29 Jan 2015
Nature Communications

Volume: 6, P: 1-16
The trans-ancestral genomic architecture of glycemic traits

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Ji Chen
Cassandra N. Spracklen
Cornelia van Duijn
Research31 May 2021
Nature Genetics

Volume: 53, P: 840-860
SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects

In patients with type 2 diabetes mellitus, sodium-glucose cotransporter 2 (SGLT2) inhibition improves glycaemic control to a therapeutically useful extent by reducing glucose reabsorption in the kidneys. This Review covers the rationale, physiological consequences and clinical application of pharmacological SGLT2 inhibition and also discusses the potential clinical merits and disadvantages of these agents.

Ele Ferrannini
Anna Solini
Reviews07 Feb 2012
Nature Reviews Endocrinology

Volume: 8, P: 495-502
Defining the role of common variation in the genomic and biological architecture of adult human height

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

Andrew R Wood
Tonu Esko
Timothy M Frayling
Research05 Oct 2014
Nature Genetics

Volume: 46, P: 1173-1186
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

A transancestral exome-wide association study for body-fat distribution identifies protein-coding variants that are significantly associated with waist-to-hip ratio adjusted for body mass index.

Anne E. Justice
Tugce Karaderi
Cecilia M. Lindgren
Research18 Feb 2019
Nature Genetics

Volume: 51, P: 452-469
SGLT inhibition in T1DM — definite benefit with manageable risk

Two phase III trials using the selective SGLT2 inhibitor dapagliflozin or the dual SGLT2/SGLT1 inhibitor sotagliflozin in patients with type 1 diabetes mellitus show similar clinical benefit (reduction of HbA_1c, body weight, blood pressure and insulin dose). The risk of hypoglycaemia and diabetic ketoacidosis with these inhibitors can be managed by careful adjustment of insulin therapy.

Ele Ferrannini
Anna Solini
News & Views27 Oct 2017
Nature Reviews Endocrinology

Volume: 13, P: 698-699
Rare and low-frequency coding variants alter human adult height

Data from over 700,000 individuals reveal the identity of 83 sequence variants that affect human height, implicating new candidate genes and pathways as being involved in growth.

Eirini Marouli
Mariaelisa Graff
Guillaume Lettre
Research01 Feb 2017
Nature

Volume: 542, P: 186-190
New genetic loci link adipose and insulin biology to body fat distribution

Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

Dmitry Shungin
Thomas W. Winkler
Karen L Mohlke
Research11 Feb 2015
Nature

Volume: 518, P: 187-196
Genetic studies of body mass index yield new insights for obesity biology

A genome-wide association study and Metabochip meta-analysis of body mass index (BMI) detects 97 BMI-associated loci, of which 56 were novel, and many loci have effects on other metabolic phenotypes; pathway analyses implicate the central nervous system in obesity susceptibility and new pathways such as those related to synaptic function, energy metabolism, lipid biology and adipogenesis.

Adam E. Locke
Bratati Kahali
Elizabeth K. Speliotes
Research11 Feb 2015
Nature

Volume: 518, P: 197-206
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index. Gene-based meta-analysis and functional studies implicate 13 genes, eight of which are novel, and neuronal pathways as factors in human obesity.

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Research22 Dec 2017
Nature Genetics

Volume: 50, P: 26-41
Diabetes research investment in the European Union

It is astonishing that, in our times, a noncommunicable disease should have acquired the cursed label of pandemic, yet such is the situation for diabetes. The numbers speak for themselves, with up to 200 million people worldwide currently suffering from the disease and the prediction that this number will double by the year 2025. In addition to the decreased life expectancy and lower quality of life of individuals with diabetes, the disease and its associated complications are a major burden on national budgets.

Philippe A Halban
Ele Ferrannini
Jørn Nerup
Comments & Opinion01 Jan 2006
Nature Medicine

Volume: 12, P: 70-72
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections16 Mar 2018
Nature Genetics

Volume: 50, P: 766-767
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections16 Mar 2018
Nature Genetics

Volume: 50, P: 765-766
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Amendments and Corrections03 Jun 2019
Nature Genetics

Volume: 51, P: 1191-1192
Type 2 diabetes mellitus

Type 2 diabetes mellitus is a chronic metabolic disorder associated with hyperglycaemia caused by impaired insulin secretion and insulin resistance. In this Primer, DeFronzo et al. discuss the pathophysiology, diagnosis, and current and future treatment strategies.

Ralph A. DeFronzo
Ele Ferrannini
Ram Weiss
Reviews23 Jul 2015
Nature Reviews Disease Primers

Volume: 1, P: 1-22
Circulating N-Acetylaspartate does not track brain NAA concentrations, cognitive function or features of small vessel disease in humans

Eleni Rebelos
Giuseppe Daniele
Ele Ferrannini
ResearchOpen Access07 Jul 2022
Scientific Reports

Volume: 12, P: 1-10
Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes

Ruchi Jain
Türküler Özgümüş
Valeriya Lyssenko
ResearchOpen Access14 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

Michaela Kozakova
Amalia Gastaldelli
Carlo Palombo
Research29 Apr 2020
Journal of Human Hypertension

Volume: 35, P: 334-342
Metabolomic Profile Predicts Development of Microalbuminuria in Individuals with Type 1 Diabetes

Jani K. Haukka
Niina Sandholm
Ele Ferrannini
ResearchOpen Access14 Sept 2018
Scientific Reports

Volume: 8, P: 1-10
Muscle and adipose tissue morphology, insulin sensitivity and beta-cell function in diabetic and nondiabetic obese patients: effects of bariatric surgery

Stefania Camastra
Alessandra Vitali
Ele Ferrannini
ResearchOpen Access21 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
Publisher Correction: Muscle and adipose tissue morphology, insulin sensitivity and beta-cell function in diabetic and nondiabetic obese patients: effects of bariatric surgery

Stefania Camastra
Alessandra Vitali
Ele Ferrannini
Amendments and CorrectionsOpen Access22 May 2018
Scientific Reports

Volume: 8, P: 1-2

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