Sister chromatids are generally assumed to be genetically and functionally identical, with segregation to daughter cells being a random process; however, some evidence contradicts both of these assumptions. A technique is now developed to observe chromatid segregation in mitotic cells in vivo. Whereas many sister chromatids appeared to be randomly distributed between daughter cells, non-random sister chromatid segregation is observed in a subset of cells.
- Ester Falconer
- Elizabeth A. Chavez
- Peter M. Lansdorp
