Nature Search

A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

Many genetic variants have been associated with human traits, but the mechanism is often unknown. Here, the authors integrate local and distal genetic associations with multi-omics datasets to provide a roadmap to understand the underlying mechanisms of GWAS variants on complex traits.

Andrew A. Brown
Juan J. Fernandez-Tajes
Ana Viñuela
ResearchOpen Access21 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis

How long does the average person sleep? Here, Kocevska et al. conducted a meta-analysis including over 1.1 million people to produce age- and sex-specific population reference charts for sleep duration and efficiency.

Desana Kocevska
Thom S. Lysen
Henning Tiemeier
Research16 Nov 2020
Nature Human Behaviour

Volume: 5, P: 113-122
Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas

Comprising data from over 18,000 people, a new atlas of drug–metabolite associations for 87 commonly prescribed drugs and 150 metabolites assessed by proton nuclear magnetic resonance provides a web-based tool to aid research on drug efficacy, safety and repurposing.

Jun Liu
Lies Lahousse
Cornelia M. van Duijn
Research13 Jan 2020
Nature Medicine

Volume: 26, P: 110-117
Lifestyle interventions for cardiometabolic health

Despite increasing availability of pharmacotherapies, interventions targeting unhealthy lifestyle behaviors continue to be critically important in the prevention and management of cardiometabolic diseases—and should be reinforced by supportive environments and policy measures.

Femke Rutters
Nicolette R. den Braver
Joline W. J. Beulens
Reviews27 Nov 2024
Nature Medicine

Volume: 30, P: 3455-3467
Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Clinical multi-omics data are integrated and analyzed using a generative deep-learning model.

Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Moustafa Abdalla
ResearchOpen Access02 Jan 2023
Nature Biotechnology

Volume: 41, P: 399-408
A reference map of potential determinants for the human serum metabolome

The levels of 1,251 metabolites are measured in 475 phenotyped individuals, and machine-learning algorithms reveal that diet and the microbiome are the determinants with the strongest predictive power for the levels of these metabolites.

Noam Bar
Tal Korem
Eran Segal
Research11 Nov 2020
Nature

Volume: 588, P: 135-140
The longitudinal association between chronic stress and (visceral) obesity over seven years in the general population: The Hoorn Studies

Noreen Z. Siddiqui
Joline W. J. Beulens
Femke Rutters
Research18 Jul 2022
International Journal of Obesity

Volume: 46, P: 1808-1817
Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Moustafa Abdalla
Amendments and CorrectionsOpen Access02 May 2023
Nature Biotechnology

Volume: 41, P: 1026

Search

Filter By:

Search

Quick links