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Mechanisms confer to the enhanced cold tolerance in japonica rice have not been fully elucidated. Here, the authors report a homeodomain-leucine zipper (HD-Zip) I transcription factor encode gene CTB5 is responsible for japonica rice cold tolerance by interacting with genes in gibberellin and abscisic acid pathways.

Low temperature is a major factor limiting productivity in rice. Here the authors show that theCTB4a gene confers cold tolerance to japonicavarieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.

Genetic basis of the drought tolerance of upland rice is unclear. Here, the authors report the cloning of a COBRA-like protein encoding gene DROT1 and reveal that it is repressed by ERF3 and activated by ERF71 to help control the balance between growth and drought tolerance in upland rice.

This study develops a nonstoichiometric covalent organic framework photocatalyst for efficient sacrificial hydrogen production from water, excelling in light absorption, charge separation, and low hydrogen-binding carbonyl sites.

The role of outer mitochondrial membrane proteins in Myocardial Ischemia-reperfusion Injury (MIRI) largely remains unknown. Here, the authors demonstrate that the outer mitochondrial membrane protein Myocardial Mitochondrial Antiviral Signaling (MAVS) protein promotes MIRI suggesting MAVS protein as potential therapeutic target.

SAMBA, a new chemically induced proximity system, overcomes the cost, complexity and reversibility challenges of such systems by precisely controlling protein interactions in a biocompatible manner mediated by salicylic acid, with applications in reprogramming oscillations, calcium signaling, receptor tyrosine kinase activation and cancer immunotherapy.

A light-inducible RNA base editor fine-tunes gene expression for therapeutics.

Improving oxygen evolution in acidic water electrolysis is vital for advancing clean hydrogen production. Here, the authors report that doping ruthenium oxide with selenium enhances efficiency and durability by tuning orbital band gaps, improving electron flow, and stabilizing oxygen vacancies.

Depending on policy design, carbon dioxide removal could either perpetuate fossil fuel consumption and slow emission reductions or, if paired with rapid emission reductions, accelerate net-zero attainment and minimize overshoot periods. Policies that simultaneously and separately mandate emission reductions and near-term carbon dioxide removals could help to prevent mitigation deterrence, while supporting the upscaling of carbon dioxide removal.

The acetylene hydrogenation activity and stability of a palladium single-atom catalyst are both controlled by the lowest unoccupied molecular orbital of the oxide support.

A space-confined chemical vapour transport strategy is reported for synthesizing multicomponent two-dimensional materials without phase separation and composition inhomogeneity. Twelve types of transition metal phosphorous chalcogenides and their high-entropy alloys (up to nine elements) are synthesized.

Harsh reaction pathways make transition metal nitride (TMN) grains susceptible to sintering. Here, the authors report a general route to synthesize multilayered TMN hollow spheres with high specific surface area from a single-source precursor.

Qiao et al. report the design and characterization of an optogenetic platform for the dynamic control of protein expression and secretion by engineered bacteria, with implications for cancer therapy.

Pulsing cellular dynamics in genetic circuits have been shown to provide critical capabilities to cells in diverse cellular activities. Here the authors show a synthetic BRET-based transgene expression system that allows pulsatile and quantitative activation of gene expression both in live cells and in vivo.

The recent experimental creation of magnetic skyrmions, topologically protected particle-like spin textures, has inspired proposals for their application in nanodevices. Here, the authors use Lorentz transmission electron microscopy to demonstrate edge-mediated skyrmion chain formation in FeGe nanostripes.

Homogeneous hydrogenolysis of organohalides using cobalt- and rhodium-catalysis under photocatalytic conditions facilitates the synthesis of deuterium- or tritium-labelled compounds with high selectivity and functional group tolerance.

The authors find that the plasticity of magnesium bismuthide (α-Mg₃Bi₂) arises from helical dislocation-driven interlayer slip, and the dispersion of lightweight Mg atoms also plays a pivotal role in facilitating strain redistribution during plastic deformation.

Searching non-charge-based devices is crucial for sustainable information processing. Here, the authors make a nonvolatile magnon field effect transistor at room temperature, enabling efficient magnon transport control via the gate voltage pulses.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

Field-free switching of the perpendicular yttrium iron garnet magnetization with considerable efficiency is desired for device performance. Here, the authors demonstrate such an accomplishment with a collinear spin current in Py.

Tumor-associated macrophages (TAMs) are associated with poor prognosis and low responses to immunotherapy. Here, authors discover that a circular RNA, circPETH, produced by TAMs generates a metabolic reprogramming in hepatocellular carcinoma that promotes metastasis and impairs the activity of cytotoxic CD8 + T cells.

The synthesis of nitrogen-containing heterocycles from biomass is scarcely known. Here, the authors report a strategy for the N-heterocyclic piperidines synthesis by one-pot amination of the bio-based furfural utilizing a Ru₁Co_NP/HAP surface single-atom alloy catalyst.

Asian soybean rust (ASR) is a devastating disease of soybean. Here, the author report the identification of an atypical pair of nucleotide-binding leucine-rich repeat (NLR) encoding genes and how they function together to confer broad-spectrum resistance to ASR.

In this triple-arm, placebo-controlled phase 3 trial, first-line treatment of patients with extensive-stage small-cell lung cancer with the anti-PD-L1 benmelstobart, tyrosine kinase inhibitor anlotinib and chemotherapy (CT) showed improved survival outcomes compared with anlotinib and CT or CT alone.

Realizing robust ferromagnetic order in two dimensions is challenging as an underlying crystalline framework is normally required. Now room-temperature ferromagnetism is demonstrated in a two-dimensional honeycomb self-assembly of confined molecules.

This work introduces CRISPRdelight, a dCas12a-based DNA-imaging tool that facilitates the imaging of non-repetitive loci and the tracking of DNA dynamics.

Single-atom catalyst (SAC) has emerged as a frontier in heterogeneous catalysis yet its robustness remains a critical concern. Here, a highly active, selective and robust Ru₁-N₃ SAC is explored for a challenging reaction, reductive amination of aldehydes/ketones for synthesis of primary amines.

Controlling the charge transfer between radical anions and cations is a promising way to tune the emission mechanism in electrochemiluminescence (ECL) systems. Here, the authors report a donor-acceptor based covalent organic framework, using triphenylamine and triazine building units, and demonstrate efficient ECL based on an adjustable intrareticular charge transfer.

Genomic, transcriptomic and DNA methylation data from tissue samples from 208 Chinese patients with prostate cancer define the landscape of alterations in this population, and comparison with data from Western cohorts suggests that the disease may stratify into different molecular subtypes.

The authors of this manuscript identify that Gpr54 activation by its natural ligand Kisspeptin-10 can abrogate bone resorption. Mechanistically, Gpr54 recruits both active Src and the Dusp18 phosphatase, which causes Dusp18 to dephosphorylate Src at Tyr 416.

Despite its importance in the context of natural gas engines emissions treatment, methane oxidation remains challenging. Now, the authors introduce an approach to stabilize PdO_x rafts on ceria by trapping Pt single atoms in the support resulting in a superior catalyst for this transformation.

The authors provide evidence in mice and humans showing that parenteral nutrition impairs glucose and insulin homeostasis by altering the gut microbiota and its metabolites.

Chromosome-level genome assemblies of three Allium crops (onion, garlic and Welsh onion) and spatial RNA sequencing provide insights into Allium trait evolution and gene expression patterns during onion bulb formation.

Protein delivery with cell-penetrating peptides suffers from ineffective endosomal escape and low tolerance in serum, thereby limiting treatment success. Here the authors present an intracellular protein delivery system and demonstrate efficient delivery in vitro and therapeutic efficacy in a liver failure model in vivo.

Layered oxide cathode materials for sodium-ion batteries often experience irreversible phase transitions and structural instability. Now researchers have developed a P2-type oxide containing earth-abundant elements, featuring an intergrowth phase structure that enables long-cycle, high-energy sodium-ion batteries.

Acetylation of p53 is critical for its transcriptional activity and its tumour suppressive function. Here, the authors show that PBRM1 is a reader protein for p53′s C-terminal ___domain acetylation on lysine 382 through its bromodomain 4 and that mutations in this ___domain leads to compromised tumour suppressive function and renal tumour growth.

Van Hove singularities (VHS) are believed to exist in one and two dimensions, but rarely found in three dimensions (3D). Here the authors report the discovery of 3D VHS in a topological magnet EuCd₂As₂ by magneto-infrared spectroscopy.

Developing efficient memory and artificial synaptic systems based on environmentally sensitive van der Waals materials remains a challenge. Here, the authors present a native oxidation-inspired InSe field-effect transistor that benefits from a boosted charge trapping behavior under ambient conditions.

Quantum devices offer the potential to simulate quantum phenomena, which are otherwise computationally intractable. Here, Shi, Sun, Wang and coauthors use a superconducting quantum simulator to study spin-transport at infinite temperature.

Synthetic biology applications require finely tuned gene expression, often mediated by synthetic transcription factors. Here the authors validate two plant-derived proteins, FHY1 and FHL, acting as transactivators in mammalian cells for orthogonal, modular, and tunable control of gene transcription by forming a photosensing transcriptional regulation complex with PhyA.