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Spatiotemporally activating DC cells in lymph nodes (LN) for cancer vaccine therapy remains a challenge. Here the authors combine antigen loaded STING nanoadjuvants with LN-confined laser or ultrasound stimulation to activate DC cells, sequentially enhances antigen-specific CD8⁺ T cell response and reduces tumor size.

The authors achieve a high electrocaloric temperature change (ΔT = 3.9 K) in c-textured BaTiO₃-KNbO₃ ceramics via compositional tuning and grain orientation engineering. The ΔT variation remain within ±10% across 30–80 °C, demonstrating exceptional stability.

This study describes sets of plasma proteins linked to AIDS- and noncommunicable disease-related deaths in people with HIV, revealing unique proteomic patterns that could improve the prediction of mortality and inform more targeted prevention and treatment.

SIRT5 protects against primate skeletal muscle ageing through TBK1 desuccinylation, which inhibits the downstream inflammatory and senescent phenotypes.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

The authors propose a matrix plainification strategy to eliminate lattice vacancies in the Cu2Se matrix of the Cu2Se/SnSe composites, resulting in obvious improvement in carrier mobility and power factor, obtaining a high figure of merit of 3.3.

The authors propose a high entropy modulation design in a quantum paraelectric ferroelectric/antiferroelectric matrix, showing high energy storage performance. Through entropy engineering, the microstructure of the material is changed with higher fluctuation on the B-site of the perovskite.

Ideal Weyl semimetals, similar to graphene, show peculiar features such as exotic electronic transport. Here, Ruan et al. predict that strain-tuned HgTe-class materials can become ideal Weyl semimetals, which could provide a promising platform to study emergent topological phenomena.

Deuterated amines play a crucial role as building blocks in drug synthesis and in identifying metabolites of novel pharmaceuticals. This study introduces a dual-functional phosphorus-doped iron single-atom catalyst that efficiently enables both reductive amination and deuteration in a one-pot process, utilizing H₂ as the reducing agent and cost-effective D₂O as the deuterium source.

Multi-year La Niña and El Niño events became more common over the past 7,000 years because of orbital forcings causing gradual changes in upper-ocean stratification in the Tropical Eastern Pacific, according to an analysis of proxy records and palaeoclimate modelling.

The conductance from bulk bands in a topological insulator usually blurs effects arising from edge states. Here, Song et al. report a Coulomb gap opened by electron–electron interactions, which effectively suppress the bulk conductance and promote observation of topological edge states in the single-layer 1T’-WTe₂.

First-principles calculations predict that Bi₂Se₃, Bi₂Te₃ and Sb₂Te₃ are topological insulators—three-dimensional semiconductors with unusual surface states generated by spin–orbit coupling—whose surface states are described by a single gapless Dirac cone. The calculations further predict that Bi₂Se₃ has a non-trivial energy gap larger than the energy scale k_BT at room temperature.

Valley states can be used to realise topologically protected transport. Here, He et al. show that considering additional degrees of freedom, together with glide symmetry, allow the design of 2D acoustic topological pseudospin-valley coupled saddle surface states in 3D structures.

Potential Majorana bound states are seen in the vortex cores of a transition metal dichalcogenide. The properties of the superconductor mean that the bound states are highly anisotropic, and can appear at higher temperatures than other materials.

The authors report on a 2D anion-rich NaCl₂ crystal with a Na:Cl ratio of approximately 1:2, which exhibits room-temperature ferromagnetism originating from the spin polarization of electrons in the Cl elements of these crystals.

Introduction of any interface will inevitably lead to a decrease in carrier mobility. Here, authors employ atomic layer deposition technology to construct composite phase interfaces, decoupling the interrelated thermoelectric parameters in n-type ZrNiSn materials.

Optical control is an alternative pathway to boost nonlinear transport in noncentrosymmetric systems. Here, the authors observe a light-induced giant enhancement of nonreciprocal transport coefficient as high as 10⁵A⁻¹ T⁻¹ at KTaO₃-based Rashba interfaces.

N-type polycrystalline SnSe shows inferior ZT to p-type polycrystalline due to its high thermal conductivity and lower power factor. The authors overcome the problem via the synergy of divacancy defect and introducing resonance level into the conduction band.

Available intrinsic magnetic topological insulators are rare. Here, the authors study the electronic and magnetic properties of Mn(Sb_xBi_(1-x))₂Te₄ bulks and thin flakes, revealing intrinsic magnetic topological insulator phase in the phase diagram.

The evolution of oceanic redox state in the past is poorly known. Here, the authors present a temporal record of banded iron formations and marine red beds, which indicate deep-ocean oxygenation occurred in the middle Ediacaran, coinciding with the onset of widespread marine red beds.

Utilizing an epoxy-amine chemistry, the authors demonstrate a thermoset epoxy that is reprocessable and tough, achieving improved sustainability for this widely used plastic material.

Pancreatic islet β cells produce insulin, so their protein quality control mechanisms are critical for human health. Here, the authors show that loss of OSGEP, an enzyme known to add the t6A modification on tRNA, disrupts proinsulin translation and causes ER stress in β cells.

The authors induce a phase boundary similar to Pb(Zr, Ti)O₃’s morphotropic phase boundary structure in (K, Na)NbO₃-based ceramics, which exhibit high residual polarization as well as a significantly improved piezoelectric constant d₃₃.

In organic photovoltaics, non-fullerene acceptors relax matching rules and allow for the development of new donor polymers. Here, Bin et al. design a donor polymer and obtain high photoconversion efficiencies despite the low energy offset for hole transfer between the acceptor and the donor.

Covalent organic frameworks (COFs) show great promise in photocatalysis but are limited by slow charge transfer. Here, the authors report a strategy to enhance the built-in electric field of COFs via ionic polarization, resulting in a hydrogen evolution rate of 9.21 mmol g^-¹ h^-¹ without Pt co-catalysts.

South Asian black carbon emissions have significantly accelerated glacier mass loss on the southern Tibetan Plateau, primarily through albedo-driven melt and precipitation reduction, resulting in a 33.7% decline in solid water storage, according to a systematic assessment of radiative and hydrological impacts from 2007 to 2016.

Large-area single-crystal high-index copper and nickel foils with several types of facet are fabricated using mild pre-oxidation of the metal foil surface followed by annealing in a reducing atmosphere.

Preclinical characterization of the SARS-CoV-2 M^pro inhibitor RAY1216 shows improved in vivo pharmacokinetics compared with nirmatrelvir.

In a cluster-randomized trial performed in 48 residential elderly care facilities in China, use of a low-sodium salt substitute instead of regular salt decreased blood pressure and cardiovascular events, whereas an alternative strategy of restricting salt consumption was not successful and did not have these beneficial effects.

Phosphoenolpyruvate carboxykinase 1 (Pck1) is an enzyme involved in glucose production that also regulates lipogenesis and has been linked to liver steatosis. Here the authors report that deficiency of Pck1 in the liver leads to nonalcoholic fatty liver disease via activation of the RhoA/PI3K/AKT pathway in a study with male mice.

Non-alcoholic fatty liver disease is a growing health burden with limited treatment options worldwide. Herein the authors report a randomized, double-blind, placebo-controlled, multiple-dose trial of a first-in-class pan-phosphodiesterase inhibitor ZSP1601 in NAFLD patients.

Targeting regulatory T cells (Treg) represents a therapeutic option to abrogate tumor-associated immune suppression. Here the authors show that pharmacological degradation of BCL-X_L preferentially induces apoptosis of tumor-infiltrating Treg, promoting CD8 T cell activation and anti-tumor immune responses in preclinical cancer models.

For relaxor ferroelectrics, correlating their properties and local structures is challenging. Here, the authors correlate the atomic-scale structure and the large dynamic electromechanical property in Bi_0.5Na_0.5TiO₃-based relaxor ferroelectrics.

The spin transport mechanism remains unclear for organic semiconductors. Here, authors investigate the effect of halogen substitution in bay-annulated indigo-based polymers and reveal the distance of substitution site from conjugated center and nitrogen atoms play crucial roles in spin relaxation.

In a randomized, double-blind, placebo-controlled phase 3 trial, the anti-vascular endothelial growth factor receptor small-molecule inhibitor fruquintinib plus chemotherapy significantly extended progression-free survival, but not overall survival, as second-line therapy in patients with advanced gastric or gastroesophageal junction cancers.

The authors fabricate highly (00l) orientated Bi₂Te₃-based films by liquid Te assistant growth method, showing high mobility stemming from high orientation and low lattice thermal conductivity, resulting from excess Te induced staggered stacking faults.

Controlling the properties of transition metal chalcogenides enables the study of new condensed-matter phenomena and the development of potential applications. Here, the authors continuously tune the crystal and electronic structure of molybdenum diselenide away from the pristine state using pressure.

In the COMPASSION-04 trial, first-line treatment with a bispecific antibody targeting CTLA-4 and PD-1 and chemotherapy in patients with locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma resulted in clinical responses with a manageable safety profile.