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Here, the authors show that Lactobacillus acidophilus supplementation enhances oncolytic virus VSVΔ51 effect through restoring gut barrier integrity and microbiota homeostasis in mice.

A variational-autoencoder-based diffusion architecture that enables topological controls on the diffusion-based protein structure generation is proposed. As a result, novel folds of mainly beta proteins can be designed with experimental validation.

The authors present an efficient hot-electron generation system facilitated by the spin-exchange Auger process in Mn2 + -doped CdS/ZnS quantum dots. These hot electrons can be used in a wide range of organic reactions, such as the Birch reduction and reductive cleavage of C-Cl, C-Br, C-I, C-O, C-C, and N-S bonds.

Here Tai et al. unveil elevated formation of the C-terminal binding protein (CtBP)–tripartite-motif-containing protein 28 (TRIM28) complex in breast cancer cells and mutual protection between CtBP and TRIM28. This complex is required for mammary gland development and its high levels lead to breast cancer metastasis by repressing autophagy.

Understanding the development of subsolid nodules (SSNs) in lung adenocarcinoma (LUAD) is important for their clinical management. Here, the authors perform proteogenomic analysis of 66 LUAD displayed as SSNs from 3 histological stages and highlight the role of endoplasmic reticulum stress in progression.

Chiral tertiary alcohols are an important structural motif, but the general methodologies for the synthesis are less reported. Herein, the authors report a Ni(ІІ)-catalyzed asymmetric alkenylation and arylation of aryl ketones with organoborons under air via a 1,5-metalate shift to obtain chiral tertiary allylic alcohols and diaryl alcohols.

Abeysundara, Rasnitsyn, Fong et al. report that the presence of leptomeningeal metastatic tumour cells leads to the recruitment and remodelling of fibroblasts, which, in turn, facilitate the colonization and outgrowth of medulloblastoma cells in the leptomeninges.

The use of base editing enables precise genetic modifications in model animals. Here the authors show high efficient single-base editing in zebrafish using modified Cas9 and its VQR variant with an altered PAM specificity.

Medullary thyroid cancer (MTC) is a neuroendocrine tumor that originates from thyroid parafollicular cells, generally associated with a poor prognosis. By comparing MTC with less aggressive papillary thyroid cancer, here the authors find that the neurotransmitter calcitonin gene-related peptide (CGRP) promotes an immunosuppressive microenvironment in MTC.

EvoScan combines EvolvR mutagenesis and phage selection to explore the protein sequence space in different dimensions, identifying anchor points with critical mutations. Next, EvoAI, a deep learning-based method, uses these anchor points to accurately reconstruct the protein sequence space and design new proteins.

RNA methylation has recently identified as an important regulatory mechanism governing functional cellular states, but its effect on the antitumour activity of CD8 ⁺ T cells is not fully explored. Here authors assign an essential nuclear, m⁶A-recognition-dependent function to YTHDF2, which, in conjunction with its regulatory role in IKZF1/3-mediated gene transcription, governs anti-tumor activity in CD8 ⁺ T cells.

This study reveals the role of the Rpd3S complex in genomic integrity, highlighting how its asymmetrical structure influences interaction with transcribed nucleosomes and elongating RNA polymerase II.

The heterogeneous characters of fibrotic scars after spinal cord injury remains unclear. Here, the authors show the heterogeneous distribution, source and function of meningeal fibroblasts and perivascular fibroblasts in fibrotic scars.

Structural and biochemical studies of the Saccharomyces cerevisiae Rpd3 small complex in free and H3K36me3 nucleosome-bound states reveal multiple nucleosome-binding modes and provide insights into mechanisms underlying epigenetic regulation by histone modification.

Chen et al. show how host genetics influence the abundance of commensal Akkermansia muciniphila in the gut, which in turn produce palmitoleic acid, thus contributing to shaping host immune responses to Mycobacterium tuberculosis infection.

The performance of wide bandgap perovskite solar cells is limited by the carrier recombination at their electron extraction interface. Here, the authors assemble binary 2D perovskites for efficient charge transport and realizing stable perovskite/silicon tandems with device efficiency over 30%.

The role of human glioma IDH1 mutations in regulation of antiviral response is unclear. Here, the authors show that D2HG produced by mutant IDH1 inhibits IFN antiviral responses in glioma cells, which confers sensitivity to oncolytic virotherapy.

The large organic cations in low-dimensional perovskite often introduces carrier mobility anisotropy and impedes charge transport. Here, authors report perovskite heterojunction with strong aromatic conjugated perovskites, realizing certified efficiency of over 25% in stable perovskite solar cells.

Carboxylated cellulose nanofibres are materials with combined sustainability and desirable properties. Here the authors show a synthetic process allowing for scalable and green preparation of such materials.

The authors present a molecular approach and a software suite for high-throughput sequencing and characterization of microbial tRNA transcripts, which provide unique physiological insights into complex environmental microbes.

Zhen and colleagues show that nuclear cGAS represses L1 retrotransposition to stabilize the genome by enhancing the interaction between ORF2p and the E3 ligase TRIM41 upon DNA damage, which leads to the ubiquitination and degradation of ORF2p.

Removal of ultrafine suspended solids from contaminated water in a cost-effective manner remains a global challenge. Here the authors develop an injection-driven filter system that is based on a fully bio-based biodegradable nanofibre hydrogel film to achieve such a goal.

Superconductivity can emerge from a strange-metal state, but the exact relationship between them is unknown. Now, quantitative measurements reveal the dependence of resistivity in the strange metal on the superconducting transition temperature.

The cellular responses below the lesion remain unclear after spinal cord injury (SCI). Here, authors show region-heterogeneous responses in the SCI monkey by single-cell transcriptomics analysis and uncover the mechanism of scaffold-based SCI repair.

BRCA1 mutation carriers have higher chances of developing triple-negative breast cancer (TNBC). Here, the authors use the Sleeping Beauty mutagenesis system in Brca1 deficient mice and identify 169 putative driver genes, of which NOTCH1 accelerates TNBC formation through promoting epithelial-mesenchymal transition and cell cycle progression.

A new type of Hall effect—the layer Hall effect—is produced in a 2D antiferromagnet that does not exhibit any net magnetization.

Defects in BRCA1, a gene involved in homologous recombination DNA repair, are common in triple negative breast cancer. Here the authors show that Brca1 deficiency in preclinical breast cancer models is associated with the accumulation of myeloid derived suppressive cells and resistance to immune checkpoint blockade, that could be overcome by targeting S100A9 and CXCL12.

Sentinel lymph nodes (SLNs) represent the sites where micro-metastasis can first develop, however they are also important to mount effective anti-tumor immune responses. Here the authors describe the design of a flex-patch loaded with anti-PD-1 antibodies and immuno-adjuvant nanosheets, layered double hydroxide, to fuel anti-tumor immune response in the SLN for postsurgical breast cancer adjuvant therapy.

A soft and lightweight neuroprosthetic hand that offers simultaneous myoelectric control and tactile feedback outperformed a conventional rigid neuroprosthetic hand in speed and dexterity.

Primary effusion lymphoma (PEL) has a very poor prognosis. Here, the authors perform H3K27ac HiChIP in PEL cells and generate the PEL enhancer connectome, linking enhancers and promoters in PEL, as well as super-enhancers to dependency factors.

Despite the availability of booster doses against SARS-CoV-2, variants of concern are capable of escaping immune responses established by vaccination or natural infection. In this work, the authors detail the immune responses elicited in a cohort of healthcare workers, receiving a fourth dose of inactivated vaccine.

Tong et al. form a 2D perovskite layer with two large organic cations to improve the structural and optoelectronic properties of Sn–Pb perovskites, and eventually the performance of single-junction and tandem solar cells.

Predicting the structure of proteins from amino acid sequences is a hard problem. Convolutional neural networks can learn to predict a map of distances between amino acid residues that can be turned into a three-dimensional structure. With a combination of approaches, including an evolutionary technique to find the best neural network architecture and a tool to find the atom coordinates in the folded structure, a pipeline for rapid prediction of three-dimensional protein structures is demonstrated.

Recently there has been interest in exploring the coupling between magnons for use in information processing, however, this is hampered by the fact that such coupling is forbidden due to the different parity of the acoustic and optical magnons. Here, Comstock et al show that the interlayer Dzyaloshinskii–Moriya-Interaction in a layered hybrid antiferromagnet can allow for strong coupling between the acoustic and optical magnons, offering a pathway for magnon coherent information processing.

Defects and defect migration are detrimental for perovskite solar cell efficiency and long-term stability. Li et al. show that fluoride is able to suppress the formation of halide anion and organic cation vacancy defects by restraining the relative ions via ionic and hydrogen bonds.

Fu et al. identify the highly conserved, transmembrane micropeptide, NEMEP, as a direct target of Nodal signaling, essential for mesendoderm differentiation. NEMEP interacts with the glucose transporters GLUT1/GLUT3 and promotes glucose uptake.

Oncolytic virotherapy is a promising strategy for cancer treatment. In this study, the authors demonstrate that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to M1 virus and improves therapeutic effects in refractory cancer models in vivo and in patient tumour samples.

Weyl and Dirac semimetals possess small material anisotropy, and under an applied field this manifests as anisotropic behaviour in magnetotransport measurements. Here, the authors report an electrically tunable chiral negative magnetoresistance for PtSe₂ which exhibits anisotropy stemmed from the asymmetric Fermi velocity.

The antiferromagnetic topological insulator MnBi₂Te₄ exhibits Chern and axion insulator phases at low magnetic field; however, its behaviour in high magnetic field has remained unexplored. Here, using transport measurements at high magnetic field, the authors report a zero Hall plateau composed of two counter-propagating edge channels.

DNA damage induces translocation of cyclic GMP–AMP synthase to the nucleus, where it suppresses homologous recombination by interfering with the formation of the PARP1–Timeless complex.