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Few-layer-thick 2D materials offer desirable electronic, thermal and mechanical properties, but their large-scale layer-controlled synthesis is still challenging. Here, the authors report an edge-feeding synchronous epitaxial growth method to synthesize homogeneous A3-sized graphene films with controlled thickness between 2 and 7 layers.

The synthesis of atom-thin amorphous films remains challenging as their thermodynamically favourable grains are neither two dimensional nor layered. Here a droplet-driven nanoribbon-to-film growth strategy is reported to achieve amorphous metal chalcogenides at the single-layer limit.

Characterization of the genetic architecture underlying the 7 pairs of contrasting traits studied by Mendel and the over 70 additional agronomic traits in pea (Pisum sativum) reveals their molecular details and provides tools for further studies in pea genetics, functional genomics and crop improvement.

Electrochemistry has emerged as an increasingly viable tool in molecular synthesis. Here the authors realize electrocatalyzed C−H activations, with the aid of data science and artificial intelligence, towards selective alkenylations for late-stage drug diversifications.

The study reveals how bortezomib activates Mycobacterium tuberculosis Clp protease complexes. Cryo-EM structures reveal how sub-stoichiometric bortezomib binding triggers structural changes, mediates holoenzyme formation and disrupts Clp system regulation.

The performance of Y6-containing donor-acceptor active layers in organic solar cells is highly related to the charge-transfer nature in Y6 aggregates. Here, authors study charge-transfer characteristics of excitations of isolated and aggregated Y6 molecules through electroabsorption spectroscopy.

The genomic and immune landscape of pre-invasive lung adenocarcinoma is poorly understood. Here, the authors perform exome and transcriptome sequencing on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alteration events linked to immune infiltration.

Co-deposition of copper thiocyanate with perovskite on textured silicon enables an efficient perovskite-silicon tandem solar cell with a certified power conversion efficiency of 31.46% for 1 cm² area devices.

ARF4 GTPase activity is needed for vesicular trafficking for multiple RNA viruses. Blocking ARF4 using specific peptides redirects viral progeny to lysosomal degradation and decreases influenza and Zika virus infection in mice.

Multiple synchronous lung cancers (MSLCs) are a subtype of lung cancer. Here the authors characterise MSLCs using single cell RNA sequencing, single cell TCR sequencing and bulk whole-exome sequencing to investigate the mutations that arise in and are associated with invasive adenocarcinoma development, and immune microenvironment changes in this process.

International shipping is a major emitter of greenhouse gases, but quantifying responsibilities has been difficult. This study uses satellite-observed data on vessels to determine the emissions from and subsequent health impacts of US–China bilateral trade of goods.

Molecular ferroelectrics possess switchable spontaneous polarization. Here, the authors show that a molecular ferroelectric crystal demonstrates evident catalytic effects on the synthesis of pharmacologically important substituted quinolines.

Yuan and colleagues show that ERMAP expression on cancer cells delivers an ‘eat me’ signal to Kupffer cells by binding to Gal-9–dectin-2 on Kupffer cells and triggering phagocytosis.

In this work, authors develop a mechano-gated iontronic piezomemristor with temporal-tactile neuromorphic plasticity, enabling bidirectional sensing, learning functions, and biohybrid integration for dynamic tactile neuromodulation.

Counterflow superfluidity is a quantum phase in which two fluid components flow in opposite directions without resistance, cancelling out their overall combined motion. This phase has now been observed in an optical lattice system hosting Bose mixtures.

This study demonstrates a WAKL4 receptor-like kinase that is rapidly and specifically induced by Cadmium. It reveals a unique mechanism conferred by the WAKL4-NRAMP1 module that enables plants to actively respond to Cadmium and limit its uptake.

The correlation between the instability and facet properties of wide-bandgap perovskites has not been revealed. Here, the authors introduce trioctylphosphine oxide for strong oriented growth of (111) facet in films and achieve certified efficiency of 30.26% for perovskite/silicon tandem solar cells.

The relationship between tissue-specific DNA methylation and cancer risk remains to be elucidated. Here, the authors predict DNA methylation at CpG sites for seven cancer types and investigate how these influence cancer risk.

Topological terms arise naturally in gauge theories but have been difficult to implement in quantum simulators. Now, a tunable topological θ-angle is demonstrated with a cold-atom platform.

A multi-ancestry genome-wide association study of problematic alcohol use in one million individuals identified 110 risk variants and shows that multi-ancestry polygenic scores improve risk prediction compared with single-ancestry scores

The neurovirulence determinants of Zika virus remain not fully established. Song et al identified a single K101R substitution in the capsid protein that contributes to the lineage-specific virulence phenotypes.

The authors study the layered superconductor AuSn₄ (T_c = 2.4 K) and reveal a two-fold symmetric angular dependence, consistent with unconventional pairing. They argue that the two-fold symmetry results from the Rashba-driven mixture of p-wave surface and s-wave bulk contributions.

Quantum spin Hall materials hold great potential for future nanoelectronics. Here, authors synthesize a potential host system — monolayer ZrTe₅ — and demonstrate it possesses a band gap wide enough for potential room-temperature applications.

The characteristics of the pores are vital for controlling the performance of covalent organic frameworks, but obtaining different chemical environments in different pores is challenging. Here, the authors report the development of covalent organic frameworks with differing pore environments.

The lack of invertible and invariant crystal representations hinders the inverse design of crystals. Here the authors develop SLICES, an invertible and invariant representation, empowering property-driven inverse design of crystals using generative AI.

Food waste is a global challenge that is strongly linked to climate change, resource consumption and human health. This study proposes a monetization approach based on a set of life-cycle assessment indicators that enables the comparison of food waste recycling technologies. The method was applied to food waste recycling in a Chinese province, revealing trade-offs and the effectiveness of different solutions.

Liu et al. report a universal solution growth method for perovskite thin monocrystals by improving the mass transfer in the high solute flux system. The approach is applied to 29 types of perovskites with growth velocity up to 27.2 µm min^-1 and enables efficient self-driven X-ray detectors.

The bacterial adhesin, RadD, enhances the ability of Fusobacterium nucleatum to interact with colorectal cancer cells and promote tumour development in mice.

Hexokinase 1 is found to be secreted from hepatic stellate cells in large extracellular vesicles in response to TGF-β, and is subsequently taken up by hepatocellular carcinoma cells, where it promotes tumor progression and metastasis.

SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicron. Applying CryoEM the authors show that ZCB11 heavy chain predominantly interacts with RBD in up confirmation, which interferes with ACE2 receptor binding.

Based on comparative single-cell transcriptomics of arterial grafts deriving from internal thoracic, radial and right gastroepiploic arteries, Hu, Dai, Chang, et al. identify factors that might prevent extracellular matrix deposition and fibrosis and improve the outcomes of coronary artery bypass grafting.

Here the authors analyzed 3.7 petavoxels of 3D imaging data from 204 mouse brains, aiming to comprehensively characterize diverse morphological and modular patterns conserved across six spatial scales of mouse brain anatomy, ranging from the whole-brain scale to synaptic levels.