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Tailored non-aqueous electrolyte solutions are formulated using data obtained from extensive analytical measurements and analyses. These optimized electrolytes improve the cycling performance of single-layer stack lithium metal pouch cells, particularly in lean electrolyte conditions.

Gene isoforms are quantified with a machine learning method that optimally integrates long and short sequencing reads.

Lewis acid additive semicarbazide hydrochloride improves the formation of α-phase FAPbI₃-based films and promotes a homogeneous vertical distribution of A-site cations through a deprotonation–reprotonation process. The upgraded device performance reaches up to 26.12% with high stability, and mini-module perovskite solar cells achieving 21.47% (area, 11.52 cm²) demonstrate great scalability.

The transcriptional phenotype of immune cells associated with severe aplastic anaemia (SAA) may change post immunotherapy. Here the authors analyse single cell transcriptomics of hematopoietic and immune cells from SAA patients and assess how these phenotypes change after treatment showing alterations in myeloid cells and TCR clonal abundance correlate with robustness of hematopoietic response.

VEXAS syndrome is a clinically heterogeneous inflammatory condition caused by mutations in the UBA1 gene. Here, by single cell transcriptomics on peripheral blood cells from VEXAS patients, the authors reveal innate and adaptive immune dysregulations irrespective of UBA1 mutations, including the presence of functionally impaired monocytes and clonal expansion of UBA1 wild-type effector memory B cells and plasmablasts.

Knockdown of lysyl-tRNA synthetase (KARS) in female Aedes aegypti leads to elevated levels of juvenile hormone and a significant decline in 20-hydroxyecdysone, thereby disrupting vitellogenesis and ovarian development.

The authors provide insights into the role of neuronal CCL2 expression, which is triggered with hyperglycaemia and modulates anxiety disorders under conditions of diabetes.

Glioma is a complex disease, and prognosis can depend on clinical, genomic and radiological information. Here, the authors develop a multimodal fusion subtyping model to integrate data modalities for predicting glioma subtypes.

The mechanism underlying YAP/TAZ transactivation remains to be explored. Here the authors report that the hydrophobic transcriptional activation domains of YAP/TAZ exert dual functions on transcriptional initiation and elongation through interactions with TAF4 and MED15, which could be targeted for anti-cancer therapy.

Mechanical degradation is an undesired behaviour for battery electrode materials such as lithiated silicon. Here, the authors performin situnanomechanical experiments and atomistic modelling to reveal the damage tolerance of electrochemically lithiated silicon.

The authors synthesize cubic GeSe through the alloying of the metavalent compound Sb₂Te₃ and vacancy engineering, achieving a record ZT of 1.38 at 723 K and an energy conversion efficiency of 6.13% in a single-leg thermoelectric device.

A plant kinase mediates symbiotic signalling and suppress host immunity to enable legume–rhizobium symbiosis.

Identifying active sites on oxide catalysts is often challenging. Here, the authors introduce a syngas-induced dispersion method to anchor ZnO species onto ZnCr₂O₄, forming monodispersed ZnO_x active sites that enhance catalytic performance in direct syngas conversion to light olefins.

The development of practical and selective strategies for deuterium incorporation to construct deuterium-labeled amino acids remains a challenge. Here, the authors report a bioinspired calcium-HFIP-mediated site-selective reductive deutero-amination of α-oxo-carbonyl compounds with amines.

Oxidative carbonylation using CO/O₂ is an attractive strategy to construct carbonyl compounds, but the explosive limit of the gas mixture hampers its application. Now, this safety issue is overcome in the aminocarbonylation of alkynes by replacing the external oxidant O₂ by electrochemistry facilitating a mild and safe reaction.

A haplotype-resolved genome of hybrid sugarcane cultivar XTT22 and population analyses of Saccharum accessions highlight the genome evolution of allopolyploids and provide opportunities for sugarcane breeding.

The patterning of perovskites faces stringent and complex fabrication processes. Here, authors realize erasable patterns based on mix-halide perovskite films via a direct photo-patterning technique, yielding multi-level pattern encoding technology.

So-called two-dimensional superconductivity has been reported in several material systems but just how thin a system can be and maintain a superconducting state has been difficult to determine. Da Jiang and colleagues demonstrate that Bi2Sr2CaCu2O8+xcontinues to be superconducting even when it is just half a unit cell thick.

Chip-Tip is a label-free quantification-based single-cell proteomics workflow for deep single-cell proteomics, which identifies over 5,000 proteins and 40,000 peptides in single HeLa cells.

In this work the authors uncover a transient non-Hermitian skin effect. Using a passive system, they confirm the exact evolution of NHSE by leveraging the complex-frequency excitation. This demonstration can be extended to other non-Hermitian phenomena in various passive systems.

Cross coupling via the activation of two carbon-hydrogen bonds avoids the need for organometallic coupling partners and associated waste. Here, the authors report a radical process that allows selective coupling between alkynes and non-activated C(sp³)-H groups via a multimetallic catalytic system.

Distinguishing benign renal masses from malignant renal tumours, and further differentiating indolent from aggressive renal cancers, on computed tomography (CT) scans remains challenging. Here, the authors develop deep learning models for distinguishing benign from malignant renal masses, and differentiating indolent from aggressive renal tumours in a large cohort of preoperative CT scans, obtaining high accuracy and a strong association with clinical outcomes.

Traditional protein engineering methods are often slow and labor-intensive. Here, authors develop an automatic protein evolution platform enabled by a protein language model. Using this platform, they significantly improved the activity of a tRNA synthetase within ten days.

Respiratory virus infection often induces excessive cytokine and chemokine production. Here the authors show in vitro that infection by the enterovirus, EV-D68, induces CXCL8/CXCR1/2 signaling and translocation of host factor, hnRNP-K, to the cytoplasm as a means to facilitate viral replication.

Material implementation of machine learning algorithms for advanced computing at cryogenic temperature remains rare. Here, the authors report a cryogenic in-memory computing platform using chiral edge states of magnetic topological insulators.

We fabricated silicon heterojunction back-contact solar cells using laser patterning, producing cells that exceeded 27% power-conversion efficiency.

The application of quantum computing to computational chemistry faces various experimental and theoretical challenges. Now, a quantum simulation on a noisy quantum device has achieved chemical accuracy for small H₂ and LiH molecules.

Angle-resolved photoemission spectroscopy of superconducting magic-angle twisted bilayer graphene reveals flat-band replicas that are indicative of strong electron–phonon coupling; these replicas are absent in non-superconducting twisted bilayer graphene.

In this study, MAX phases (ternary transition metal nanolaminates) were produced using conformal synthesis to achieve one-dimensional form. The grown nanofibers were combined with copper to demonstrate the potential for composites.

“Understanding the structure-property relationship of organic molecules which exhibit different properties upon aggregation is important for the field of material science. Here, the authors prepare nonconjugated rhodamine-based molecules without aggregation-induced emission building blocks yet displaying typical aggregation-induced emission behavior.”

A well-designed national coal phase-out pathway in China that considers diverse technology portfolios and plant-level sequential decision-making processes can save over 700 billion dollars and elevate mitigation potential.

A ternary metallic alloy VS_2xSe_2(1–x) that has a tunable work function can be grown using chemical vapour deposition and used as contacts for two-dimensional semiconductors.

Single-cell ATAC-seq reveals gene regulation at individual cell levels but struggles with data sparsity. Here, authors introduce scAGDE, a deep graph learning framework that improves cell embedding and clustering, outperforming existing methods and uncovering key regulatory mechanisms.

The haplotype-resolved genome of tetraploid modern rose, along with a variation map of 233 wild and cultivated Rosa accessions, reveals the complex genome composition of modern roses and elucidates the genomic bases of their origin and breeding.

Intestinal microbiota alterations may affect heart function through the production of gut-derived metabolites. Here the authors found that gut microbiota-derived TMAVA is a key determinant for the development of cardiac hypertrophy through inhibition of carnitine synthesis and subsequent fatty acid oxidation.