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Although theoretical advances in the reactivity of organic compounds have progressed rapidly, a complete understanding of the causal relationships between molecular structures and reaction outcomes based solely on first principles remains elusive. Here, the authors use an in-house HTE platform to conduct over 11,000 distinct acid amine couplings, with an accompanying Bayesian neural network model that gives a prediction accuracy of 89.48% for reaction feasibility.

Substantial open-circuit voltage loss and inherent non-radiative recombination hinder efficiency improvements in wide-bandgap perovskite solar cells. Here the authors augment two-dimensional perovskite phases on the surface to promote (100) facet growth on three-dimensional perovskite facets, improving the open-circuit voltage and efficiency of the resulting wide-bandgap perovskite solar cells.

The pre-and postsynaptic communication is critical for faithful synaptic transmission and induction of synaptic plasticity. Here, the authors found that CaMKII functions at GABAergic neurons to recruit GABA_ARs by triggering anterograde signals.

The sustainable fabrication of perovskite solar cells is critical. Duan et al. present a more environmentally friendly solvent system to process wide-bandgap perovskite films that can also be used for industrial-scale manufacturing in ambient air.

Using a mixture of 4-fluorophenethylamine and 4-trifluoromethyl-phenylammonium to create a tailored 2D perovskite layer reduces the inhomogeneity at the top interface of all-perovskite tandem cells and results in the highest efficiency reported so far.

Current LiDAR approaches suffer from congestion issues, which affect measurement performance and increased system complexity. Now researchers demonstrate a chaotic microcomb that exhibits congestion-immune naturally orthogonalized light channels.

Optical neural networks face remarkable challenges in high-level integration and on-chip operation. In this work the authors enable optical convolution utilizing time-wavelength plane stretching approach on a microcomb-driven chip-based photonic processing unit.

Previous chaos suffers from limited parallelism for high-speed systems. Here the authors harness chaotic microcombs as parallel chaos, demonstrating low inter-channel correlation and high throughput for random bit generation and optical decision making.

A simple and power-efficient microcomb source is used to drive complementary metal–oxide–semiconductor silicon photonic engines, a step towards the next generation of fully integrated photonic systems.

The scalable fabrication of wide-bandgap perovskites in air remains challenging due to moisture-induced degradation of perovskites. Here, authors utilize low polarity and moderately volatile n-butanol to enhance film uniformity, achieving efficiency of 29.4% for double-sided textured tandem cells.

TEMPOmap combines pulse-chase metabolic labeling with multiplexed three-dimensional in situ sequencing to simultaneously profile the age and subcellular ___location of individual RNA molecules from thousands of genes to reveal RNA kinetic landscapes.

Researchers demonstrate the high-coherence parallelization in integrated photonics. Their high-coherence, high-power, multiwavelength light source drives a silicon photonic link with a 60 Tbit/s data rate and significantly reduces digital signal processing consumption.

Despite larger nonlinear coefficients, waveguide losses have prevented using semiconductors instead of dielectric materials for on-chip frequency-comb sources. By significantly reducing waveguide loss, ultra-low-threshold Kerr comb generation is demonstrated in a high-Q AlGaAs-on-insulator microresonator system.

Understanding the spatiotemporal dynamics underlying pathology can shed light on its mechanisms. Here the authors introduce STARmap PLUS, a method that combines high-resolution spatial transcriptomics with protein detection.

The superstate configuration in all-perovskite tandem solar cells is disadvantageous for long-term stability. Here, the authors reverse the processing order and demonstrate substrate configuration to bury oxidizable narrow-bandgap perovskites, and achieve efficiency of 25.3% with long stability.

The conventional solution post-treatment is suboptimal for methylammonium-free and cesium/bromide-enriched wide-bandgap perovskite solar cells. Here, the authors develop a 3D-to-2D perovskite conversion approach for a preferential growth, achieving stabilized efficiency of 28.1% for tandem cells.

Energy-level mismatches and defects at the inorganic perovskite/fullerene interface limit the performance of solar cells. Now Li et al. address these issues with a dipolar molecule, enabling the use of wide-bandgap inorganic perovskites in all-perovskite tandem cells.

We demonstrate theoretically and experimentally that the stepwise phase dispersion compensation layer releases the numerical aperture, operation bandwidth, and aperture size from the tradeoffs of achromatic flat lens, allowing their flexible design.

Authors report quantum decoherence of dissipative Kerr solitons in normal-dispersion microresonators, also known as dark pulses. They show the quantum decoherence of dark pulses and their potential advantages over bright solitons in an AlGaAs-on-insulator system.

In situ transcriptomics maps RNA expression patterns across intact tissues taking our understanding of gene expression to a new level. Here, the authors present a computational method that uncovers gene expression, cell niche, and tissue region patterns from 2D and 3D spatial transcriptomics.

Reliable detection of mutations below 0.5% variant allele frequency remains a key challenge for circulating tumor DNA sequencing assays.

A DNA molecular computation platform allows the rapid diagnosis of lung cancer with high accuracy by analysing specific miRNA levels in clinical serum samples.

Genetic variations influence the risk of prostate cancer. Here, the authors use a meta-analysis of Genome-wide association studies from Asian populations and uncover new susceptibility loci at 11p15.4 and 14q23.2.

Hifiasm is a haplotype-resolved de novo genome assembler for long-read high-fidelity sequencing data based on phased assembly graphs.

Yinghao Sun and colleagues report a genome-wide association study for prostate cancer in Han Chinese men. They identify two new risk-associated loci at chromosomes 9q31 and 19q13.