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Showing 1–2 of 2 results
Advanced filters: Author: Hayden J. Selvadurai Clear advanced filters

  • Previous work shows that a small population of quiescent SOX2+ medulloblastoma (MB) stem cells can drive tumour growth in early tumorigenesis and relapse. Here, the authors identify OLIG2 as a transcriptional mediator of the transition from quiescent to rapidly proliferating progenitor states and therapeutically target this axis in preclinical models of MB.

    • Kinjal Desai
    • Siyi Wanggou
    • Peter B. Dirks
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Using unique barcodes for tumour cells, the authors explore the dynamics of human glioblastoma subpopulations, and suggest that clonal heterogeneity emerges through stochastic fate decisions of a neutral proliferative hierarchy.

    • Xiaoyang Lan
    • David J. Jörg
    • Peter B. Dirks
    Research
    Nature
    Volume: 549, P: 227-232