Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Heather Whetstone Clear advanced filters

  • Previous work shows that a small population of quiescent SOX2+ medulloblastoma (MB) stem cells can drive tumour growth in early tumorigenesis and relapse. Here, the authors identify OLIG2 as a transcriptional mediator of the transition from quiescent to rapidly proliferating progenitor states and therapeutically target this axis in preclinical models of MB.

    • Kinjal Desai
    • Siyi Wanggou
    • Peter B. Dirks
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • In a new report, Benjamin Alman and his colleagues find that the morphogenic pathway activated by Hedgehog signaling is a key mediator of osteoarthritis, a condition that is marked by irreversible degeneration of the joints and with no current treatment. They also found that blockade of Hedgehog signaling prevented osteoarthritis in a mouse model, suggesting this pathway as a possible target to treat this devastating disease.

    • Alvin C Lin
    • Brian L Seeto
    • Benjamin A Alman
    Research
    Nature Medicine
    Volume: 15, P: 1421-1425

  • The reparative capacity of tissues decreases with age. Here, Baht et al. perform parabiosis experiments and provide evidence for the existence of a soluble factor produced by young, but not old, haematopoietic cells that is capable of improving fracture repair in old mice.

    • Gurpreet S. Baht
    • David Silkstone
    • Benjamin A. Alman
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in vivo, suggesting that PRMT5 inhibition may be a useful therapeutic strategy

    • Patty Sachamitr
    • Jolene C. Ho
    • Peter B. Dirks
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Using unique barcodes for tumour cells, the authors explore the dynamics of human glioblastoma subpopulations, and suggest that clonal heterogeneity emerges through stochastic fate decisions of a neutral proliferative hierarchy.

    • Xiaoyang Lan
    • David J. Jörg
    • Peter B. Dirks
    Research
    Nature
    Volume: 549, P: 227-232

  • The rate of repair declines with age; however, exposure to young circulations can rejuvenate fracture repair, but how this is accomplished is unknown. Here, the authors identify proteins, including low-density lipoprotein receptor-related protein 1 (Lrp1), as being secreted from young macrophages and rejuvenating fracture repair in mice.

    • Linda Vi
    • Gurpreet S. Baht
    • Benjamin A. Alman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12