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The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Cystoid macular oedema after flanged intraocular lens scleral fixation using the Yamane technique: a multicentre cohort study

Hiroto Ishikawa
Kazutaka Uchida
Fumi Gomi
ResearchOpen Access04 Jan 2025
Scientific Reports

Volume: 15, P: 1-8
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Apoptosis of leukemia cells induced by valine-deficient medium

K Ohtawa
T Ueno
Y Inada
Correspondence29 Oct 1998
Leukemia

Volume: 12, P: 1651-1652
Cardiovascular Remodeling and Metabolic Abnormalities in SHRSP.Z-Lepr^fa/IzmDmcr Rats as a New Model of Metabolic Syndrome

Takahiro Ueno
Hiroto Takagi
Yukio Yamori
Research01 May 2008
Hypertension Research

Volume: 31, P: 1021-1031
In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.

Tsunamasa Watanabe
Hiroto Hatakeyama
Michinori Kohara
ResearchOpen Access23 Apr 2014
Scientific Reports

Volume: 4, P: 1-11
Safety comparisons among monoamine oxidase inhibitors against Parkinson’s disease using FDA adverse event reporting system

Hiroto Asano
Yu-Shi Tian
Kenji Ikeda
ResearchOpen Access06 Nov 2023
Scientific Reports

Volume: 13, P: 1-10
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Exploration of serum biomarkers in dogs with malignant melanoma receiving anti-PD-L1 therapy and potential of COX-2 inhibition for combination therapy

Naoya Maekawa
Satoru Konnai
Kazuhiko Ohashi
ResearchOpen Access03 Jun 2022
Scientific Reports

Volume: 12, P: 1-11

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The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

Blood DNA virome associates with autoimmune diseases and COVID-19

Cystoid macular oedema after flanged intraocular lens scleral fixation using the Yamane technique: a multicentre cohort study

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Apoptosis of leukemia cells induced by valine-deficient medium

Cardiovascular Remodeling and Metabolic Abnormalities in SHRSP.Z-Lepr^fa/IzmDmcr Rats as a New Model of Metabolic Syndrome

In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.

Safety comparisons among monoamine oxidase inhibitors against Parkinson’s disease using FDA adverse event reporting system

Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Exploration of serum biomarkers in dogs with malignant melanoma receiving anti-PD-L1 therapy and potential of COX-2 inhibition for combination therapy

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