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The blood ApoM-S1P complex regulates vascular functions, but its role in neurogenic niches remains unclear. Here, the authors show that the blood ApoM-S1P complex preserves V-SVZ homeostasis and protects against early features of Alzheimer’s disease.

The authors present a chip-less wearable sensor-processor integrated neuromorphic system that combines multimodal physicochemical sensing with neuromorphic processing for real-time, autonomous physiological monitoring.

Cytidine triphosphate synthase, a key enzyme in nucleotide synthesis, forms distinct filaments in Mycobacterium tuberculosis that resist cytidine triphosphate feedback inhibition, which are characterised through structural, biochemical, and cellular methods.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

This study reports the direct 3D quantitative mapping of local nitrogen distribution across a range of silicon-based semiconductor structures and devices using atom probe tomography, offering nanoscale insights into impurity control and contributing to improved device performance and reliability.

A variant in the IFITM3gene increases the risk of severe influenza, but homozygosity is rare in Caucasians. The authors show that the variant gene is homozygous in 25% of healthy Chinese people, and 69% of those with severe pandemic influenza, suggesting that this gene influences the epidemiology of influenza in South-East Asia.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Accurate prediction of surgical outcomes is essential for selecting treatment plans and ensuring patient satisfaction in corrective jaw surgery (orthognathic surgery). Here, the authors present and validate GPOSC-Net, a generative model for orthognathic surgery planning, to predict surgical movement and synthesize post-operative cephalograms from pre-operative data using a diffusion model.

Here, the authors show that reduced transport of UDP-GlcNAc to the endoplasmic reticulum and Golgi leads to increased cytosolic UDP-GlcNAc and O-GlcNAcylation in chondrocytes. This, in turn, stabilizes the transcription factor GATA4, promoting the senescence-associated secretory phenotype and exacerbating osteoarthritis.

HEPN–MNT is a bacterial type VII toxin-antitoxin (TA) system, comprising the HEPN toxin and the MNT antitoxin. Crystal structures and functional assays of the HEPN–MNT module suggest that HEPN is a metal-dependent RNase and identify its active site residues and regulatory mechanism.

The aging immune system is characterized by changes in immune cell frequencies and functionality. Here the authors report dynamics of age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors

With advances in robotic technology, the complexity of control of robot has been increasing owing to fundamental von Neumann bottlenecks. Here, we demonstrate coordinated movement by a fully parallel-processable synaptic array with reduced control complexity.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

The addition of magnetic dopants to semiconductor quantum dots can enhance the quantum efficiency of photon-to-exciton conversion through spin-exchange carrier multiplication. Here, the authors show that this effect can be utilized to boost photocurrent in films of Mn-doped CdSe/HgSe quantum dots with an inverted band structure.

Precise genome editing is crucial. Here the authors demonstrate that dual inhibition of p53-mediated cell death and distinct activation of the DNA damage repair system upon DNA damage by cytosine base editor (CBE) or prime editor (PE) additively enhanced editing efficiency in hPSCs.

Loss-of-function mutations in Myosin Binding Protein C3, MYBPC3, are the most common genetic cause of hypertrophic cardiomyopathy. Here, the authors present an AAV9-based gene therapy system with an optimized expression cassette with minimal promoter and cis-regulatory elements that can ameliorate cardiac functions and prolong survival in a murine MYBPC3-deficient model.

GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain imaging genomics.

Lung tissue-resident memory T cells play critical roles in the response to and protection to subsequent re-exposure and infection with influenza viruses. Here the authors explore vaccine induced lung resident memory T cells and their role in protection to heterosubtypic influenza infection in mice and ferrets.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Thiirane, the sulfur congener of oxirane, has been hard to access in a stereodefined form. Here, the authors accomplished a highly stereoselective synthesis of cis-diarylthiiranes through the stereospecific sulfurization of E,E-aldazine N-oxides.

Semiconductors are promising for high performance spintronics but the low functioning temperature hampers their applications. Here the authors achieve a strong room temperature modulation of spin-dependent resistance in GaN nanowires, which marks an important step towards practical spintronic devices.

Tobacco smoking is an important risk factor for lung cancer. Here the authors report that tobacco carcinogens promote metabolic syndrome and metabolic reprogramming of macrophages, associated with lung cancer progression in preclinical models.

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

Here, the authors utilise NMR and MD simulations to reveal how transcription factor Meis1 distinguishes target DNA sequences through non-specific binding.

Skin irritation is a common challenge for commercial wearable biosignal sensors due to direct contact with the skin. Here, the authors suggest a lightweight, flexible fabric-based lamina emergent MXene electrode as a solution.

Conventional therapies can induce cancer cell senescence. Here the authors show that therapy-induced senescent cancer cells can escape T-cell immunity by upregulating PD-L1, whose expression and glycosylation levels are regulated by ribophorin 1.

Achieving long-term sustainable dropwise condensation of low-surface-tension refrigerants has been a decades-long challenge. The authors introduce a coating that facilitates dropwise condensation of fluorinated refrigerants, significantly improving heat transfer and showcasing durability across various substrates.