Search

Single-cell RNA sequencing, whole-exome sequencing and spatial transcriptome sequencing of gallbladder adenocarcinomas from 75 patients stratifies the disease into groups with distinct clinical outcomes.

Memristive and near-threshold computing hold potential for the next-generation edge AI hardware, but their scalability remains a bottleneck. Wang et al. combine the two paradigms to achieve parallel Mb-level computing, whereby the variation in memristors cancels out the intrinsic transistor mismatch.

Supported single atoms are promising catalysts for alkane dehydrogenation, although tuning their reactivity via active site modulation remains a challenge. Here the authors introduce an Ir₁–Cu₁ dual-atom catalyst for n-butane dehydrogenation that outperforms the corresponding Ir₁ single-atom system.

TyroID is a proximity labeling method that maps extracellular proteins with high spatiotemporal resolution through plant- and bacteria-derived tyrosinases. TyroID efficiently labels proteins in vivo to study of localization and interactions.

Previously, ion escape was expected to be steady under constant external conditions. Here, the authors show that ion escape at Mars exhibits anomalous spatial-temporal variability.

Lung and gastrointestinal diseases often occur together. Here, the authors present a multi-ancestry study showing the shared genetic architecture between lung and gastrointestinal diseases.

Ma et al. identify a highly conserved PIWI-interacting RNA CRAPIR, as a key regulator of cardiomyocyte proliferation and heart repair after myocardial infarction through the PA2G4–NF110–NF45 signaling axis.

Forest soils are vital in regulating the atmospheric CH₄ budget, but their response to warming varies spatially. The authors assess the temperature response of soil microbial CH₄ oxidation across 84 forest sites in China, finding higher temperature sensitivity in colder regions, indicating greater CH₄ sink potential in these areas with warming.

Current treatments for fundus disorders face safety and efficacy challenges. Here, the authors developed a wearable electrodriven switch that enables macromolecule delivery to the fundus

TAK1 is a key mediator of human inflammatory bowel diseases (IBD) through the NF-kB pathway. Here, the authors show that TAK1 phosphorylates TRADD, which cooperates with RIPK1 to intestinal pathology and inflammation in a mouse model of IBD.

It is highly desired to explore cheap, non-toxic transition metals catalysts for semihydrogenation of acetylene. Here, isolated Cu atoms anchored onto a defective nanodiamond-graphene support exhibit robust catalytic performance in acetylene semihydrogenation in comparison with supported Cu clusters.

Here, Ma et al. investigate the translational profile of cardiac regeneration, pointing to Nat10 as a key regulator of cardiomyocyte proliferative potential, and describing how it regulates cardiac gene expression.

This study demonstrates that future whole-soil warming has a much stronger effect on soil carbon emission in the alpine grassland ecosystem than what is estimated by previous warming experiments which only warm surface soils mostly.

Hydrogenating di-nitroaromatics with high activity and selectivity is challenging due to the process’s complexity. Here the authors present a fully exposed Pt clusters catalyst for 2,4-dinitrotoluene hydrogenation, suggesting that the synergy between multiple active sites and moderate adsorption behavior is crucial for the high catalytic activity.

The functional role of DPF3, a component of the SWI/SNF chromatin remodelling complex associated with clear cell renal cell carcinoma (ccRCC), remains unknown. Here, the authors characterise the mechanism by which DPF3 promotes metastasis via the activation of the TGF-β signalling pathway in ccRCC.

Long noncoding-RNAs have been linked to hepatocellular carcinoma (HCC) and some can be used as prognostic markers. Here the authors, by analysing RNA-seq in 60 clinical samples from 20 patients, provide a resource of functional lncRNAs and biomarkers associated with HCC tumorigenesis and metastasis.

Activation of the cGAS-STING pathway has been associated with the promotion of anti-tumor immunity. Here the authors show that TET2 upregulates tumor cGAS to activate STING in endothelial cells, inducing tumor vascular normalization and enhancing efficacy of anti-PD-L1 alone or combined with IL-2 in liver cancer preclinical models.

Spot2vector, a graph-enhanced autoencoder with ZINB modeling, flexibly adjusts spatial-expression coupling to adapt to diverse dataset morphologies, resolving domains and denoising gene expression across spatial transcriptomics platforms

Approaches to treat inflammatory bowel disease with probiotics or artificial enzymes have advantages and limitations. Here we combine the advantages to overcome the individual limitations by modifying probiotics with artificial enzymes and demonstrate application in treating inflammatory bowel disease.

The Chinese Liver Cancer Atlas project depicts a panoramic genomic landscape of hepatocellular carcinoma, covering candidate coding and non-coding drivers, mutational signatures, extrachromosomal circular DNA, subclonal catastrophic events and detailed evolutionary history.

BRCA1 dysfunction sensitizes cancer cells to PARP inhibitors (PARPi) but the underlying mechanism is unclear. Here, the authors identify RNF19A as a determinant of PARPi sensitivity, showing that RNF19A ubiquitinates BARD1, negatively regulates the BRCA1-BARD1 complex, and inhibits homologous recombination.

Achieving direct solar-to-hydrogen conversion from pure water using solely organic heterogeneous catalysts is still challenging. Here the authors report an all-organic semiconductor catalyst system for overall water splitting under visible to near-infrared light via triplet-triplet annihilation up conversion based on spin coupling.

Despite being a promising treatment for hepatocellular carcinoma (HCC), resistance to tyrosine kinase inhibitors (TKI) present a major obstacle. Here, the authors demonstrate that lipid metabolism reprogramming via URI mediated stearoyl-CoA desaturase 1 upregulation present a targetable driver of sorafenib resistance in HCC.

The preferential oxidation of CO (PROX) in hydrogen is a promising solution for hydrogen purification. Here the authors report a novel bimetallic Pt-Fe catalyst with ultralow metal loading which delivers excellent catalytic activity and selectivity in PROX, while maintains good stability for a long period.

Phosphorylation of INSIG1 and INSIG2 by PCK1 leads to a reduction in the binding of sterols, the activation of SREBP1 and SREBP2 and the downstream transcription of lipogenesis-associated genes that promote tumour growth.

Direct dehydrogenation has been a thematic research area resulting from the energy shortage and petroleum gas upgrading scenario. Here, the authors fabricate fully exposed Pt₃ clusters and correlate dehydrogenation activity with average coordination number of Pt-Pt bond.

Qui et al. perform co-detection by indexing profiling of 401 hepatocellular carcinoma patient samples and identify a role for vimentin^high macrophages in instructing an immune-suppressive microenvironment by enhancing the suppressive activity of regulatory T cells via interleukin-1β.

Cellular metabolism is altered in many cancer types and the advent of metabolomics has allowed us to understand more about how this is dysregulated. Here, the authors report a method named CARVE to analyse the arterial supply and venous drainage of glioma patients during surgery and identify the metabolites that may be consumed and produced by the cancer.

Single-site pincer-ligated iridium complexes exhibit the ability for C-H activation but suffer from instability and difficulty in catalyst recycling. Here the authors design an atomically dispersed Ir catalyst which can be considered the bridge between homogeneous and heterogeneous catalysis and displays an outstanding catalytic performance in n-butane dehydrogenation.

Muscle spindles sense muscle tension to coordinate body movement. This paper reveals a mechanism of spindle formation and maintenance and to better understanding changes in movement in muscle disorders and ageing.

Phenological shifts driven by climate change are well-studied in plants and aboveground animals, but scarcely in belowground biota. Here, the authors show that soil warming causes phenological mismatches between plants, soil microbes and soil microarthropods in an alpine meadow.

Soil microbes produce more methane as temperatures warm, but it is unclear if they acclimate to heat, or keep producing more of the greenhouse gas. Here the authors use artificial wetland warming experiments to show that after initial spikes in methane emissions after warming, emissions level out over time.

The selective hydrogenation of nitriles to prepare corresponding amines is highly desired in chemistry industry. Here, the authors selectively obtained secondary amines and primary amines over two types of atomically dispersed Pd catalysts supported on the nanodiamond-graphene hybrid support.

The direct observation of in-plane charged ___domain walls in BiFeO₃ ferroelectric films a few nanometres thick, their deterministic creation, manipulation and annihilation by applied voltage, as well the demonstration of their memristive functionality is reported.

Climate change may result in larger releases of CH₄ than CO₂ from wetlands as CH₄ emissions seem to be more sensitive to temperature. Globally, CO₂ and CH₄ emissions show a similar temperature dependence but this is modulated by wetland water table depth, which affects CH₄ (but not CO₂) emissions.

Operando investigation of the CO₂ reduction mechanism at gas diffusion electrodes is a challenging task. Here proton-transfer-reaction time-of-flight mass spectrometry has been deployed to analyse the intermediates and products at copper electrodes in real time.

Carbon dioxide removal can minimize the scale of asset stranding in the power sector but at a risk of increased committed emissions under 1.5° and 2° climate targets, according to a multi-sector model analysis of six carbon removal technologies.

Sibilia and colleagues report that IL-1-dependent EGFR induction in liver macrophages is needed to stimulate IL-6 production, which in turn promotes hepatocyte proliferation and hepatocellular carcinoma formation.