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Propane dehydrogenation (PDH) is critical for propylene production, yet overcoming the trade-off between activity and stability remains a challenge. Here a robust Pt@Sn-MFI catalyst is developed for PDH, leveraging the synergy between Pt and hydroxyl sites.

Detecting small molecules is pivotal across many fields. Here, authors leverage a split crRNA mode to construct spatially blocked split CRISPR-Cas12a system. This approach establishes a low-background, highly sensitive platform for small molecule detection.

COPD patients are more likely to also have diabetes. Here the authors show that the use of SGLT2 inhibitors was associated with reduced all-cause mortality, hospitalization, acute exacerbations, and pneumonia in patients with COPD and diabetes.

Immunotherapy holds great potential, although strategies for durable responses against solid tumors are still needed. Here, the authors combine oncolytic virus (OV) engineering and reprogramming of the IL-18 pathway, showing that armed OVs expressing a decoy-resistant IL-18 elicit anti-tumor immunity and long-term immunological memory against multiple refractory tumors in mice.

During electrocatalytic nitrate reduction, cobalt-based catalysts degrade fast due to the combined effect of nitrate oxidation and electric-field reduction. Here, the authors develop a Co6Ni4 heterostructured catalyst to prevent high valence Co accumulation and achieve efficient ammonia synthesis.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

This study presents an optical cloud computing system that enables long-distance, high-speed AI processing and communication with low power consumption. The approach offers a scalable and secure alternative to electronic cloud computing, addressing key energy and privacy challenges.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Traditional oxime synthesis involves hazardous, energy-intensive processes, highlighting the need for greener alternatives. Here, the authors report anode-cathode cascade electrosynthesis that sustainably and efficiently produces various oximes from hydroxyl compounds and nitrate.

The authors use human SEEG recordings during a virtual escape task to identify roles for cognitive and reactive fear circuits in threat evaluation and escape decisions, respectively. They further uncover Theta-band flow from the amygdala to the vmPFC during rapid attacks.

DNA Damage Regulated Autophagy Modulator 1 (DRAM1) plays pivotal roles in autophagy regulation. Here, the authors show that DRAM1 stabilizes lysosomal VAMP8, thereby promoting autolysosome maturation. Furthermore, they establish that DRAM1–VAMP8 axis enhances autophagic flux and facilitates hepatocellular carcinoma extravasation, as validated in both zebrafish xenograft and mouse metastatic models.

Indian dwarf wheat (Triticum sphaerococcum) is thermotolerant, but the underlying mechanism is unclear. Here, the authors report the cloning of the heat tolerance gene encoding a STKc_GSK3 kinase and its variation affects phosphorylation level of downstream TaPIF4 in determining thermotolerance.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

The immunomodulatory functions of mast cells (MCs) within the tumor microenvironment are elusive. Here, the authors present a transcriptomic characterization of LUAD-infiltrating MCs and identify a proinflammatory subset that contributes to the activation of cytotoxic MAIT cells by secreting IL-18 via NRLP3 activation and pyroptosis, ultimately boosting anti-tumor immunity.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

Metabotropic glutamate receptor 4 (mGluR4) is a neurotransmitter receptor receiving signals from the central nervous system. Here authors show a non-neuronal, tumour-autonomous role for mGluR4 in suppressing dendritic cell maturation and function in multiple murine cancers, and that inhibiting mGluR4 chemically by Forskolin or via genomic deletion enhances the immune response against tumours.

T-cell enrichment has attracted great interest but currently fails to fully replicate the complex natural immune interactions. Here, the authors report on magnetic polymerised antigen-presenting cells that mimic natural interactions to isolate rare tumour-reactive T cells, offering a platform for enhancing cancer immunotherapy and neoantigen discovery.

Xu, Meng, St-Germain et al. report that S1P in HDL induces a calcium signalling cascade involving E-Syt1 that ultimately promotes the formation of contact sites between the endoplasmic reticulum and the plasma membrane, as well as HDL-derived cholesterol transport.

Urate oxidase (Uox) lost its function during evolution. Here the authors propose an atavistic strategy to treat hyperuricemia by using a proprietary lipid nanoparticle to load Uox mRNA, which reduced the serum uric acid levels effectively in two animal models.

How spatial gene expression patterns are orchestrated by enhancers is not fully elucidated. Here the authors present a computational framework called eSpatial revealing a “spatial enhancer code,” where divergent enhancer combinations regulate spatial gene expression during development and diseases.

A study of human and mouse models of pancreatic cancer finds that inhibiting the lipid kinase PIKfyve interferes with the cancer’s lipid homeostasis, making it a potential target for drug development.

Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

This study shows how auditory cortex activation and cognitive function develop during a six-month follow-up after gene therapy in children with congenital deafness.

The CAPItello-291 phase 3 study reported that capivasertib (an AKT inhibitor) and fulvestrant (a selective estrogen receptor degrader) improved progression free survival in patients with HR-positive/HER2-negative advanced breast cancer. Here, the authors report the results of an extended Chinese cohort recruited as part of the original global CAPItello-291 study.

Effective lossless compression requires that frequent patterns in the data can be identified. Li et al. explore using deep learning models to more effectively compress text, audio and video data.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor FOXP3, with consequences on T_reg cell-suppressive function and IBD pathology.

The role of outer mitochondrial membrane proteins in Myocardial Ischemia-reperfusion Injury (MIRI) largely remains unknown. Here, the authors demonstrate that the outer mitochondrial membrane protein Myocardial Mitochondrial Antiviral Signaling (MAVS) protein promotes MIRI suggesting MAVS protein as potential therapeutic target.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Preferred orientation in cryo-EM often limits structural resolution. Here, the authors present cryoPROS, a novel computational method that co-refines raw and deep generative auxiliary particles to correct misalignment, enabling near-atomic resolution from challenging datasets.

Commonly used opioids for pain management primarily target the mu opioid receptor. However, mu opioid receptor agonists often come with harmful side effects. Here, the authors report the results of two phase 3 trials of HSK21542 (anrikefon), a highly selective activator of peripheral kappa opioid receptor agonists, for postoperative pain treatment following abdominal surgery.

This study demonstrated that different types of HC-Pros from potyviruses exhibit varying capacities to inhibit HEN1. This results in distinct levels of autophagic AGO1 degradation, which in turn leads to differences in RNA silencing suppression efficiency.

This study reveals the genetic basis of Benzylisoquinoline alkaloids (BIAs) biosynthesis in magnoliids, and further illustrates that preferentially retained ancient gene duplicates enabled BIA production in early-diverging eudicots and magnoliids.

Although transition metal-based complexes featuring metal atoms in formally negative oxidation states are known, their stabilization without an organic ligand remains challenging. Now, lanthanide–nickel intermetallic complexes featuring an organic-ligand-free Ni²⁻ ion bound to electropositive lanthanides have been stabilized in fullerenes.

The cobalt-catalyzed intermolecular reductive coupling of alkenes and alkynes is attractive due to the unique reactivity and cost-effectiveness of cobalt catalysts. Here, the authors report an asymmetric desymmetric reductive coupling of electronically unbiased succinimide-containing cyclobutenes with internal alkynes via photoredox and cobalt dual catalysis.

Understanding the development of subsolid nodules (SSNs) in lung adenocarcinoma (LUAD) is important for their clinical management. Here, the authors perform proteogenomic analysis of 66 LUAD displayed as SSNs from 3 histological stages and highlight the role of endoplasmic reticulum stress in progression.